Biochemical Engineering Journal, Journal Year: 2024, Volume and Issue: 211, P. 109475 - 109475
Published: Aug. 30, 2024
Language: Английский
Medical Review, Journal Year: 2024, Volume and Issue: 4(2), P. 129 - 153
Published: March 13, 2024
Abstract In the field of biomedical research, organoids represent a remarkable advancement that has potential to revolutionize our approach studying human diseases even before clinical trials. Organoids are essentially miniature 3D models specific organs or tissues, enabling scientists investigate causes diseases, test new drugs, and explore personalized medicine within controlled laboratory setting. Over past decade, organoid technology made substantial progress, allowing researchers create highly detailed environments closely mimic body. These can be generated from various sources, including pluripotent stem cells, specialized tissue tumor cells. This versatility enables replicate wide range affecting different organ systems, effectively creating disease replicas in dish. exciting capability provided us with unprecedented insights into progression how we develop improved treatments. this paper, will provide an overview progress utilizing as preclinical models, aiding understanding providing more effective addressing diseases.
Language: Английский
Citations
7
Lung Cancer, Journal Year: 2024, Volume and Issue: 190, P. 107533 - 107533
Published: March 14, 2024
Language: Английский
Citations
7
Organoid, Journal Year: 2025, Volume and Issue: 5, P. e1 - e1
Published: Jan. 25, 2025
Patient-derived tumor organoids (PDTOs) provide powerful platforms for modeling human tumors, offering insights into cancer biology and personalized therapy development. Incorporating clinical knowledge—such as staging, molecular profiling, treatment outcomes—enhances the relevance of PDTO research. Lung staging systems guide sample selection, thereby influencing organoid growth response studies. Clinical endpoints characteristics further align experiments with real-world therapeutic challenges patient care. Despite their potential, research faces in replicating heterogeneity microenvironment, both which are critical studying drug resistance efficacy. Addressing these complexities requires close collaboration between researchers clinicians to ensure that models accurately reflect course disease. This review provides information on integrating research, focusing aspects such endpoints, implications staging. By bridging gap basic oncology, aims enhancing translational value work. A clear understanding can support development more robust models, ultimately advancing strategies improving outcomes.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 95 - 114
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biofabrication, Journal Year: 2024, Volume and Issue: 16(3), P. 032009 - 032009
Published: April 12, 2024
High failure rates of the current drug development process are driving exemplary changes toward methodologies centered on human disease
Language: Английский
Citations
3
Organogenesis, Journal Year: 2024, Volume and Issue: 20(1)
Published: Aug. 10, 2024
With the rapid development of field life sciences, traditional 2D cell culture and animal models have long been unable to meet urgent needs modern biomedical research new drug development. Establishing a generation experimental is great significance for deeply understanding human health disease processes, developing effective treatment measures. As well known, cycles, high risks, costs are "three mountains" facing drugs today. Organoids organ-on-chips technology can highly simulate reproduce physiological environment complex reactions in
Language: Английский
Citations
3
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: May 20, 2024
Cancer therapy is on the brink of a significant transformation with inclusion patient-derived organoids (PDOs) in drug development. These three-dimensional cell cultures, directly derived from patient's tumor, accurately replicate complex structure and genetic makeup original cancer. This makes them promising tool for advancing oncology. In this review, we explore practical applications PDOs clinical screening pharmacognostic assessment, as well their role refining therapeutic strategies. We provide insights into latest advancements PDO technology its implications predicting treatment responses facilitating novel discoveries. Additionally, address operational challenges associated incorporating development process, such scaling up organoid ensuring consistent results, addressing ethical use materials. Aimed at researchers, clinicians, key stakeholders oncology, article aims to succinctly present both extraordinary potential obstacles integrating PDOs, thereby shedding light prospective impact future cancer treatment.
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 23, 2024
Lung cancer remains one of the leading causes cancer-related mortality worldwide, necessitating innovative research methodologies to improve treatment outcomes and develop novel strategies. The advent three-dimensional (3D) cell cultures has marked a significant advancement in lung research, offering more physiologically relevant model compared traditional two-dimensional (2D) cultures. This review elucidates various types 3D culture models currently used pharmacology, including spheroids, organoids engineered tissue models, having pivotal roles enhancing our understanding biology, facilitating drug development, advancing precision medicine. systems mimic complex spatial architecture microenvironment tumours, providing critical insights into cellular molecular mechanisms tumour progression, metastasis responses. Spheroids, derived from commercialized lines, effectively (TME), formation hypoxic nutrient gradients, crucial for evaluating penetration efficacy anti-cancer therapeutics. Organoids tumouroids, primary tissues, recapitulate heterogeneity cancers are instrumental personalized medicine approaches, supporting simulation vivo pharmacological responses patient-specific context. Moreover, these have been co-cultured with biomimicry extracellular matrix (ECM) components further heterotypic cell-cell cell-ECM interactions present within TME. significantly contributing identification therapeutic targets resistance against conventional therapies. Therefore, this summarizes latest findings involving together common laboratory-based assays study effects. Additionally, integration development workflows is discussed. accelerating translation laboratory clinical applications, thereby landscape treatment. By closely mirroring human not only enhance disease but also pave way effective
Language: Английский
Citations
2
Small, Journal Year: 2024, Volume and Issue: 20(27)
Published: Feb. 2, 2024
Abstract The mortality rate among cancer patients is primarily attributed to tumor metastasis. evaluation of metastasis potential provides a powerful framework for personalized therapies. However, little work has so far been undertaken precisely model in vitro, hindering the development preventive and therapeutic interventions. In this work, tumor‐metastasis‐mimicked Transwell‐integrated organoids‐on‐a‐chip platform (TOP) evaluating metastatic developed. Unlike conventional Transwell device detecting cell migration, engineered facilitates assessment patient‐derived organoids (PDO). Furthermore, novel chamber with hexagon‐shaped structure developed mimic migration cells into surrounding tissues, allowing horizontal direction. As proof‐of‐concept demonstration, clusters are further evaluated at protein, genetic, phenotypic levels. addition, preliminary drug screening highlight using combat cancers. summary, TOP offers unique capabilities contributes
Language: Английский
Citations
1
Synthetic and Systems Biotechnology, Journal Year: 2024, Volume and Issue: 10(1), P. 86 - 101
Published: Aug. 30, 2024
Tissue on a chip or organ-on-chip (OOC) is technology that's dignified to form transformation in drug discovery through the use of advanced platforms. These are 3D
Language: Английский
Citations
1