Synthesis and characterization of cerium oxide-bacteriocin nanohybride with synergistic biological activities DOI Open Access

Sana M.H. Al-Shimmary,

Zina Hashem Shehab, Emad Hamdi Jassim

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 1 - 16

Published: Dec. 17, 2024

The creation of adjuvants that can increase the effectiveness therapeutically accessible antibiotics is overall strategy due to limited therapeutic choices available for treating multidrug-resistant (MDR) infections. Thus, goal this work was create a novel cerium oxide-bacteriocin nanohybrid (CeO2-bacteriocin nanohybrid), which purified from Lactobacillus acidophilus (L. acidophilus) and may help bacteriocins become more bioactive overcome several obstacles. Characterization nanohybrids via methods has been performed. X-ray diffraction (XRD) revealed an average crystallite size 37.19 nm. Transmission electron microscopy (TEM) confirmed CeO2-bacteriocin composed regular spheres oval shapes with sizes ranging 6 61 Scanning (SEM) demonstrated structure tended be spherical, varying between 45 65 As result, showed strong antibacterial activity than bacteriocin alone, there were highly significant (p ≤ 0.01)differences in effects alone on growth each tested bacteria Minimum Inhibition Concentration Bactericidal against MDR Staphylococcus aureus XDR Acinetobacter baumannii recorded. promising antibiofilm all bacteria. new considered choice as antioxidant compound DPPH (2,2-diphenyl-1-picrylhydrazyl) vitro cytotoxicity breast cancer cells (MDA-MB-231 cells).

Language: Английский

The regulatory mechanisms of cerium oxide nanoparticles in oxidative stress and emerging applications in refractory wound care DOI Creative Commons
Lijun Yi,

Lijian Yu,

Shouying Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Cerium oxide nanoparticles (CeNPs) have emerged as a potent therapeutic agent in the realm of wound healing, attributing their efficacy predominantly to exceptional antioxidant properties. Mimicking activity endogenous enzymes, CeNPs alleviate oxidative stress and curtail generation inflammatory mediators, thus expediting healing process. Their application spans various disease models, showcasing potential treating responses infections, particularly stress-induced chronic wounds such diabetic ulcers, radiation-induced skin injuries, psoriasis. Despite promising advancements laboratory studies, clinical translation is challenged by several factors, including biocompatibility, toxicity, effective drug delivery, development multifunctional compounds. Addressing these challenges necessitates CeNP synthesis functionalization, novel nano delivery systems, comprehensive bio effectiveness safety evaluations. This paper reviews progress highlighting mechanisms, applications, challenges, future perspectives therapeutics.

Language: Английский

Citations

9
Electrospun Composites of Chitosan with Cerium Oxide Nanoparticles for Wound Healing Applications: Characterization and Biocompatibility Evaluation In Vitro and In Vivo DOI Open Access
В. А. Петрова, Daria N. Poshina, А. С. Головкин

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1787 - 1787

Published: June 25, 2024

Cerium oxide nanoparticles (CeONPs), as part of tissue regeneration matrices, can protect cells from reactive oxygen species and oxidative stress. In addition, they influence the properties scaffold, including its electrospinnability mechanical strength. this work, we prepared electrospun fiber mats a chitosan polyethylene blend (CS-PEO) with addition ceria (CS-PEO-CeONP). The CeONPs resulted in smaller diameter higher swelling compared to CS-PEO mats. CeONP-modified also had Young’s modulus due reinforcing effect nanoparticles. Both comparable adhesion cytocompatibility mesenchymal stem cells, which more rounded morphology on CS-PEO-CeONP elongated Biocompatibility an vivo rat model showed no acute toxicity, septic or allergic inflammation, rough scar formation. degradation both passed stage matrix swelling. significantly slower biodegradation, most remaining after 90 days. inflammation was aseptic nature involvement multinucleated foreign-body type giant reduced by day 90. induced formation implant’s connective capsule. Thus, introduction influenced physicochemical biological activity nanofiber

Language: Английский

Citations

4
Multifunctional CoCe/silica and CoMnCe/silica spinel ferrite nanocomposite: in vitro and in vivo evaluation for cancer therapy DOI
B. Rabindran Jermy, Farah Khan, Vijaya Ravinayagam

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101251 - 101251

Published: July 16, 2024

Language: Английский

Citations

4
Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing DOI
Burcu Orhan, Duygu Karadeniz, Zeynep Kalaycıoğlu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138924 - 138924

Published: Dec. 1, 2024

Language: Английский

Citations

4
Effects of Nano-cerium Oxide on the Levels of DHT, TGF-β, and IGF-1 in the Local Skin of AGA Model Mice and Efficacy Observation DOI Creative Commons
Andy Dong, Guohui Zhang

Journal of Contemporary Medical Practice, Journal Year: 2025, Volume and Issue: 7(1), P. 100 - 105

Published: Jan. 31, 2025

Objective: Explore the improvement effect of nano-cerium oxide on mice with androgenetic alopecia. Methods: First, backs were depilated and an alopecia model was established by treating them 5mg/kg testosterone propionate. C57BL/6 randomly divided into 5 groups: blank group, roller microneedle minoxidil group. Corresponding treatment substances introduced areas respectively. The ratio terminal hairs to vellus (T/V) in observed through HE histological examination. contents dihydrotestosterone (DHT), transforming growth factor-β (TGF-β), insulin-like factor-1(IGF-1) skin tissues determined enzyme-linked immunosorbent assay (ELISA). Results: Compared drug - treated groups could increase T/V mice, elevate protein expression level IGF-1, decrease TGF-β as well content DHT mouse skin. Conclusions: Nano-cerium has a certain ability alleviate It can hair hair, providing some theoretical guidance for development drugs prevention

Language: Английский

Citations

0
Facile and straightforward fabrication of antimicrobial Cu-Ce oxide nanoagent for repair of acutely infected wounds DOI Creative Commons
Jinhui Lin, Zhaowei Wang,

Jiangshan Hu

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113901 - 113901

Published: March 1, 2025

Language: Английский

Citations

0
Effect of high temperature annealing on the electronic structure and antioxidant properties of ablated Cerium dioxide nanoparticles DOI
V. А. Mamontov, М. А. Пугачевский, А. С. Сизов

et al.

Proceedings of the Southwest State University Series Engineering and Technologies, Journal Year: 2025, Volume and Issue: 15(1), P. 123 - 134

Published: April 7, 2025

Purpose . Study of the dependence electronic structure and antioxidant properties ablated cerium dioxide nanoparticles on annealing temperature under photocatalytic reaction conditions in presence titanium nanoparticles. Methods Nanoparticles were obtained by laser ablation. The average sizes subjected to centrifugation high-temperature calculated from AFM images. A change was detected spectrophotometry, sedimentation annealed studied. Also, activity photocatalysis process determined using a spectrophotometer. Results centrifuged be range 46,3±0,5 nm 82,8±0,5 nm. studies revealed bathochromic shift energy position 4f0 states Ce4+ ions bandwidth bandgap after annealing, its effect not revealed. It found that during nanoparticles, degradation rate methylene blue dye increases, i.e., CeO2 decreases. Conclusion : From results presented this paper it follows influence physicochemical change, particular, their decreases, but an aqueous solution remains constant.

Language: Английский

Citations

0
A novel multifunctional self-assembled nanocellulose based scaffold for the healing of diabetic wounds DOI

Guangrui Ma,

Lina Fu, Hao Wang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 361, P. 123643 - 123643

Published: April 24, 2025

Language: Английский

Citations

0
Phyto-mediated synthesis of CeO2/ZrO2 nanocomposite: A potential performer for multifarious biomedical applications DOI

S. Priyadharshini,

S. Gobalakrishnan, Muniappan Ayyanar

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Bacterial Cellulose-Based Nanocomposites for Wound Healing Applications DOI Open Access

Alexandra-Ionela Dogaru,

Ovidiu Oprea, Gabriela Isopencu

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1225 - 1225

Published: April 29, 2025

Bacterial cellulose (BC) is a polysaccharide produced by Gram-positive and Gram-negative bacteria with strictly aerobic metabolism, having huge number of significant applications in the biomedical field. This study investigates development bacterial (BC)-based composite systems that incorporate cerium dioxide nanoparticles (CeO2 NPs) used as antibacterial agents to enhance wound healing, particularly for burn treatments. The innovation this resides integration CeO2 NPs synthesized using precipitation method both chemical green reducing agents, ammonium hydroxide (NH4OH) turmeric extract (TE), BC membranes composed ultrathin nanofibers interwoven into three-dimensional network appearing hydrogel mass. Characterization scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared (FTIR) confirmed effective deposition agent onto matrix. Antibacterial activity tests against E. coli B. subtilis indicated strong inhibition composites following these routes, BC-CeO2-TE-OH sample, processed employing precipitating agents. Cytotoxicity evaluations showed no cell activity. Additionally, loading dexamethasone endowed them analgesic release over 4 h, observed through ultraviolet-visible (UV-Vis), while FTIR spectra revealed sustained drug presence post-release. These findings highlight BC-based films promising candidates advanced care tissue engineering applications.

Language: Английский

Citations

0