Trends in cancer,
Journal Year:
2023,
Volume and Issue:
9(11), P. 937 - 954
Published: Aug. 8, 2023
During
tumor
progression,
mechanical
abnormalities
in
the
microenvironment
(TME)
trigger
signaling
pathways
cells
that
activate
cellular
programs,
resulting
growth
and
drug
resistance.
In
this
review,
we
describe
mechanisms
of
action
for
anti-cancer
therapies
mechanotransduction
programs
regulate
processes,
including
cell
proliferation,
apoptosis,
survival
phenotype
switching.
We
discuss
how
therapeutic
response
is
impacted
by
three
main
TME
abnormalities:
high
extracellular
matrix
(ECM)
composition
stiffness;
interstitial
fluid
pressure
(IFP);
elevated
forces.
also
review
drugs
normalize
these
or
block
mechanosensors
pathways.
Finally,
current
challenges
perspectives
development
new
strategies
targeting
mechanically
induced
resistance
clinic.
npj Biological Physics and Mechanics.,
Journal Year:
2025,
Volume and Issue:
2(1)
Published: Feb. 4, 2025
Abstract
The
cancer
metastatic
cascade
includes
a
series
of
mechanical
barrier-crossing
events,
involving
the
physical
movement
cells
from
their
primary
location
to
distant
organ.
This
review
describes
changes
that
influence
tumour
proliferation,
progression,
and
metastasis.
We
identify
potential
signatures
at
every
step
discuss
some
latest
mechanobiology-based
therapeutic
interventions
highlight
importance
interdisciplinary
approaches
in
diagnosis
treatment.
Life Science Alliance,
Journal Year:
2025,
Volume and Issue:
8(3), P. e202402854 - e202402854
Published: Jan. 2, 2025
Mechanical
stresses,
including
compression,
arise
during
cancer
progression.
In
solid
cancer,
especially
breast
and
pancreatic
cancers,
the
rapid
tumor
growth
environment
remodeling
explain
their
high
intensity
of
compressive
forces.
However,
sensitivity
compressed
cells
to
targeted
therapies
remains
poorly
known.
cells,
pharmacological
PI3K
inactivation
decreased
cell
number
induced
apoptosis.
These
effects
were
accentuated
when
we
applied
2D
compression
forces
in
mechanically
responsive
cells.
Compression
selectively
overexpression
isoforms
PI3K/AKT
pathway
activation.
Furthermore,
transcriptional
inhibition
converged
control
expression
an
autophagy
regulator,
GABARAP,
whose
level
was
inversely
associated
with
inhibitor
under
compression.
alone
blocked
flux
all
tested
whereas
basal
activity
restored
only
non-responsive
This
study
provides
direct
evidence
for
role
compression-induced
mechanotransduction.
promotes
apoptosis
or
autophagy,
explaining
importance
survival
Frontiers in Pharmacology,
Journal Year:
2018,
Volume and Issue:
9
Published: Oct. 31, 2018
Recent
developments
in
nanotechnology
have
brought
new
approaches
to
cancer
diagnosis
and
therapy.
While
enhanced
permeability
retention
effect
(EPR)
promotes
nanoparticle
(NP)
extravasation,
the
abnormal
tumor
vasculature,
high
interstitial
pressure
dense
stroma
structure
limit
homogeneous
intratumoral
distribution
of
NP
compromise
their
imaging
therapeutic
effect.
Moreover,
heterogeneous
nontumor-stroma
cells
damages
nontumor
cells,
interferes
with
tumor-stroma
crosstalk.
This
can
lead
inhibition
progression,
but
also
paradoxically
induce
acquired
resistance
facilitate
cell
proliferation
metastasis.
Overall,
microenvironment
plays
a
crucial,
yet
controversial
role
regulating
biological
effects.
In
this
review,
we
summarize
barriers
discuss
consequential
effects
considerations
improve
delivery
propose
potential
combinatory
strategies
overcome
induced
by
microenvironment.
The
various
that
been
adopted
discussed
review
article.
Trends in Cell Biology,
Journal Year:
2021,
Volume and Issue:
31(6), P. 457 - 472
Published: March 10, 2021
Mechanotransduction
is
the
ability
of
a
cell
to
sense
mechanical
cues
from
its
microenvironment
and
convert
them
into
biochemical
signals
elicit
adaptive
transcriptional
other
cellular
responses.
Here,
we
describe
recent
advances
in
field
regulation
transcription,
highlight
epigenome
as
key
novel
aspect
mechanotransduction,
technological
that
could
further
elucidate
link
between
stimuli
gene
expression.
In
this
review,
emphasize
importance
mechanotransduction
one
governing
principles
cancer
progression,
underscoring
need
conduct
studies
molecular
mechanisms
involved
sensing
coordinating
