Microbial Pathogenesis, Journal Year: 2022, Volume and Issue: 164, P. 105414 - 105414
Published: Jan. 29, 2022
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)
Published: Nov. 10, 2021
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long (lncRNAs), and circular (circRNAs), are closely related variety biological functional aspects human health. When the exosomal ncRNAs undergo tissue-specific changes due diverse internal or external disorders, they can cause tissue dysfunction, aging, diseases. In this review, we comprehensively discuss underlying regulatory mechanisms exosomes in addition, explore current knowledge on roles miRNAs, lncRNAs, circRNAs health diseases, including cancers, metabolic neurodegenerative cardiovascular autoimmune infectious determine their potential implication biomarker identification therapeutic exploration.
Language: Английский
Citations
273
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: June 26, 2023
Abstract Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune fibroblasts, other components, thereby regulating critical aspects of cancer progression including escape, angiogenesis, metabolism, drug resistance, proliferation metastasis. Interestingly, microenvironment have new findings in influencing escape mediated by the release exosomal circRNA. Given intrinsic stability, abundance, broad distribution circRNAs, they represent excellent diagnostic prognostic biomarkers for liquid biopsy. Moreover, artificially synthesized circRNAs may open up possibilities therapy, potentially bolstered nanoparticles or plant exosome delivery strategies. In this review, we summarize functions underlying mechanisms cell non-tumor cell-derived progression, with special focus on their roles immunity metabolism. Finally, examine potential application therapeutic targets, highlighting promise clinical use.
Language: Английский
Citations
98
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: April 1, 2024
Abstract Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor has a significant impact on mortality rates. Nevertheless, swift advancement of contemporary technology not seamlessly aligned with evolution detection methodologies, resulting in deficit innovative efficient clinical assays for GIC. Given that exosomes are preferentially released by myriad cellular entities, predominantly originating from neoplastic cells, this confers composition enriched cancer-specific constituents. Furthermore, exhibit ubiquitous presence across diverse biological fluids, endowing them inherent advantages non-invasiveness, real-time monitoring, specificity. The unparalleled render as an ideal liquid biopsy biomarker early diagnosis, prognosticating potential development GIC metastasis. In review, we summarized latest research progress possible targets cancer-derived (CDEs) emphasis mechanisms exosome promoting metastasis, highlighting roles CDEs treatment
Language: Английский
Citations
19
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Abstract Exosomes have emerged as versatile biomolecules in gastrointestinal (GI) cancer management, leveraging their inherent cargo‐carrying capabilities to overcome the limitations of current diagnostic and therapeutic strategies. This review provides a comprehensive exploration exosome‐based technologies, highlighting dual roles biomarkers vehicles. On front, this investigates specific exosomal biomarkers—including miRNAs, lncRNAs, circRNAs, proteins—emphasizing tumor biology clinical utility, such accuracy, early detection potential, prognostic significance. Therapeutically, study examines sources, purification methodologies, engineering strategies that enhance efficacy exosomes modulating immune responses, overcoming drug resistance, suppressing metastasis. By providing overview field, serves guideline for researchers clinicians entering offering novel insights into potential theranostic systems delineating future directions existing challenges.
Language: Английский
Citations
2
Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: April 5, 2022
Abstract Exosomes are microvesicles secreted by cells. They contain a variety of bioactive substances with important roles in intercellular communication. Circular RNA (circRNA), type nucleic acid molecule found exosomes, forms covalently bonded closed loop without 5′ caps or 3′ poly(A) tails. It is structurally stable, widely distributed, and tissue specific. CircRNAs mainly act as microRNA sponges have regulatory gene expression; they superior to other non-coding RNAs molecular diagnostic markers drug treatment targets. Exosomal-derived circRNAs the body fluids tumor patients can modulate proliferation, invasion, metastasis, resistance. be used effective biomarkers for early non-invasive diagnosis prognostic evaluation tumors, also represent ideal targets precision therapeutic intervention. This review provides theoretical basis exploring applications exosomal malignant treatment. We describe biological functions occurrence development their potential utility treatment, possible mechanisms.
Language: Английский
Citations
44
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: April 28, 2022
As a novel class of endogenous non-coding RNAs discovered in recent years, circular (circRNAs) are highly conserved and stable covalently closed ring structures with no 5′-end cap or 3′-end poly(A) tail. CircRNAs formed by reverse splicing, mainly means noose structure intron complementary pairing. Exosomes tiny discoid vesicles diameter 40-100 nm that secreted cells under physiological pathological conditions. play an important role cell-cell communication carrying DNA, microRNAs, mRNAs, proteins circRNAs. In this review, we summarize the biological functions circRNAs exosomes, further reveal potential roles exosomal different diseases, providing scientific basis for diagnosis, treatment, prognosis wide variety diseases.
Language: Английский
Citations
36
Environmental Research, Journal Year: 2023, Volume and Issue: 227, P. 115683 - 115683
Published: March 17, 2023
Language: Английский
Citations
19
International Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 17(12), P. 3059 - 3079
Published: Jan. 1, 2021
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide.HCC has high rates death and recurrence, as well very low survival rates.N6-methyladenosine (m6A) most abundant modification in eukaryotic RNAs, circRNAs are a class circular noncoding RNAs that generated by back-splicing they modulate multiple functions variety cellular processes.Although carcinogenesis HCC complex, emerging evidence indicated m6A circRNA play vital roles development progression.However, underlying mechanisms governing HCC, their cross-talk, clinical implications have not been fully elucidated.Therefore, this paper, we elucidated biological molecular illustrating three different regulatory factors ("writer", "eraser", "reader") process.Additionally, dissected functional various malignant behaviors thereby contributing to initiation, progression relapse.Furthermore, demonstrated cross-talk interplay between revealing effects collaboration on progression.Finally, proposed potential modifiers diagnostic biomarkers therapeutic targets for diagnosis, treatment prognosis evaluation.
Language: Английский
Citations
41
Journal of Oncology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15
Published: Jan. 28, 2022
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Since patients with HCC are diagnosed at intermediate or advanced stage and because has a high incidence of metastasis recurrence, it one leading causes cancer death. Exosomes subtype extracellular vesicles typically 30-150 nm in diameter. Originating from endosomes, they can be secreted by almost all living cells. They widely present various body fluids serve as an important medium for interactions between A series studies have revealed that exosomes-mediated intercellular transfer proteins, nucleic acids, metabolites plays crucial role initiation progression HCC, hypoxia angiogenesis, chemotherapy sensitivity, cell death mode regulates immune microenvironment. In this paper, we reviewed recent researches on multiple roles tumor-associated exosomes HCC. We laid particular focus those reveal how regulate tumor microenvironment (TIME) exosomal cargos affect Besides, emphasize some prospective directions to achieve more accurate complete analysis
Language: Английский
Citations
28
Journal of Immunology Research, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15
Published: May 6, 2022
Extracellular vesicles (EVs) are vesicular bodies (40-1000 nm) with double-layer membrane structures released by different cell types into extracellular environments, including apoptosis bodies, microvesicles, and exosomes. Exosomes (30-100 enclosed contain effective molecules of secretory cells. They derived from intracellular multivesicular (MVBs) that fuse the plasma release their exocytosis. Research has shown almost all human cells could secrete exosomes, which have a certain relationship corresponding diseases. In chronic liver diseases, exosomes variety bioactive components spaces, mediating intercellular signal transduction materials transport. Moreover, play role in diagnosis, treatment, prognosis various diseases as potential biomarkers therapeutic targets. Previous studies found mesenchymal stem cell-derived (MSC-ex) alleviate acute injury advantages high biocompatibility low immunogenicity. this paper, we briefly summarize pathogenesis latest research progresses MSC-ex clinical
Language: Английский
Citations
28