TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1327 - 1327

Published: June 23, 2023

The channels from the superfamily of transient receptor potential (TRP) activated by reactive oxygen species (ROS) can be defined as redox channels. Those with best exposure cysteine residues and, hence, most sensitive to oxidative stress are TRPC4, TRPC5, TRPV1, TRPV4, and TRPA1, while others, such TRPC3, TRPM2, TRPM7, indirectly ROS. Furthermore, activation ROS has different effects on tumorigenic process: some TRP may, upon activation, stimulate proliferation, apoptosis, or migration cancer cells, others inhibit these processes, depending type, tumoral microenvironment, finally, methods used for evaluation. Therefore, using polymodal proteins therapeutic targets is still an unmet need, despite their draggability modulation simple mostly unharmful compounds. This review intended create cellular models interaction between stress, channels, inflammation. Although somewhat crosstalk three actors was rather theoretical, we gather recently published data proposed pathways inhibition modulators proteins, hoping that experimental corroborated clinical information may finally bring results bench bedside.

Language: Английский

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The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum

Redox Biology, Journal Year: 2023, Volume and Issue: 68, P. 102950 - 102950

Published: Oct. 30, 2023

One in five patients with Inflammatory Bowel Disease (IBD) suffers from anemia, most frequently caused by iron deficiency. Anemia and deficiency are associated worse disease outcomes, reduced quality of life, decreased economic participation, increased healthcare costs. International guidelines consensus-based recommendations have emphasized the importance treating anemia In this review, we draw attention to rarely discussed effects therapy on redox status, intestinal microbiota, potential interplay between them, focusing clinical implications for IBD. Current data scarce, inconsistent, do not provide definitive answers. Nevertheless, it is imperative rule out infections discern other types prevent untargeted oral or intravenous supplementation side effects, including oxidative stress. Further research necessary establish significance changes status microbiota following supplementation.

Language: Английский

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Mitochondrial Dysfunction in Kidney Tubulopathies

Annual Review of Physiology, Journal Year: 2023, Volume and Issue: 86(1), P. 379 - 403

Published: Nov. 28, 2023

Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water solute reabsorption processes along the nephron. Moreover, mitochondria contribute cellular health by regulation of autophagy, (oxidative) stress responses, apoptosis. Mitochondrial abundance is particularly high cortical segments, including proximal distal convoluted tubules. Dysfunction has been described for tubulopathies such as Fanconi, Gitelman, Bartter-like syndromes renal tubular acidosis. In addition, mitochondrial cytopathies often affect (tubular) tissues, Kearns-Sayre Leigh syndromes. Nevertheless, mechanisms which dysfunction results diseases are only scarcely being explored. This review provides an overview development progression tubulopathies. Furthermore, it emphasizes need further mechanistic investigations identify links between function electrolyte reabsorption.

Language: Английский

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Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Toxics, Journal Year: 2024, Volume and Issue: 12(2), P. 161 - 161

Published: Feb. 19, 2024

Numerous toxicological studies have highlighted the association between urban particulate matter (PM) and increased respiratory infections lung diseases. The adverse impact on lungs is directly linked to complex composition of matter, initiating reactive oxygen species (ROS) production consequent lipid peroxidation. Excessive ROS, particularly within mitochondria, can destroy subcellular organelles through various pathways. In this study, we confirmed induction ferroptosis, an iron-dependent cell death, upon exposure PM using RT-qPCR signaling pathway analysis. We used KRISS CRM 109-02-004, certified reference material for analysis produced by Korea Research Institute Standards Science (KRISS). To validate that ferroptosis causes endothelial toxicity, assessed intracellular mitochondrial potential, ROS overproduction, peroxidation, specific biomarkers. Following PM, a significant increase in generation decrease potential were observed. Furthermore, it induced hallmarks including accumulation loss antioxidant defenses, cellular iron accumulation. addition, occurrence oxidative stress as key feature was expression levels markers such NQO1, CYP1B1, FTH1, SOD2, NRF. Finally, observed, xCT/SLC7A11, TRIM16, HMOX-1, FTL, CHAC1, GPX4. This provides evidence elevated induce stress, which ultimately triggers ferroptosis. conclusion, our results show CRM, induces production, leading subsequent These suggest may offer strategies treatment

Language: Английский

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Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 26, 2024

Abstract Background Cardiovascular diseases (CVDs) have the highest mortality worldwide. Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) offer a valuable resource for disease modeling, pharmacological screening, regenerative therapy. While most CVDs are linked to significant over-production of reactive oxygen species (ROS), effects current antioxidants targeting excessive ROS limited. Nanotechnology is powerful tool develop with improved selectivity, solubility, bioavailability prevent or treat various related oxidative stress. Cerium oxide nanozymes (CeONZs) can effectively scavenge by mimicking activity endogenous antioxidant enzymes. This study aimed assess nanotoxicity CeONZs potential benefits in stressed human embryonic (hESCs) derived cardiomyocytes (hESC-CMs). Results demonstrated reliable nanosafety biocompatibility hESCs hESC-CMs within broad range concentrations. exhibited protective on cell viability alleviating ROS-induced Moreover, protected from doxorubicin (DOX)-induced cardiotoxicity partially ameliorated insults DOX neonatal rat (NRCMs). Furthermore, during culture, were found reduce ROS, decrease apoptosis, enhance survival without affecting self-renewal differentiation potential. Conclusions displayed good safety biocompatibility, as well enhanced shielding them damage. These promising results suggest that may be crucial, safe nanoantioxidant, potentially improve therapeutic efficacy incorporated into medicine. Graphical

Language: Английский

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