Journal of Perinatology, Journal Year: 2023, Volume and Issue: 43(6), P. 741 - 745
Published: Feb. 22, 2023
Language: Английский
Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(10), P. 789 - 801
Published: July 27, 2023
Language: Английский
Citations
61
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(4), P. 1650 - 1650
Published: Feb. 19, 2023
In humans, the gut microbiota (GM) are known to play a significant role in metabolism of nutrients and drugs, immunomodulation, pathogen defense by inhabiting gastrointestinal tract (GIT). The GM gut–brain axis (GBA) has been documented for different regulatory mechanisms associated pathways it shows behaviors with individualized bacteria. addition, as susceptibility factor neurological disorders central nervous system (CNS), regulating disease progression being amenable intervention. Bidirectional transmission between brain occurs GBA, implying that performs neurocrine, endocrine, immune-mediated signaling pathways. regulates multiple supplementing them prebiotics, probiotics, postbiotics, synbiotics, fecal transplantations, and/or antibiotics. A well-balanced diet is critically important establishing healthy GM, which can alter enteric (ENS) regulate disorders. Here, we have discussed function GBA from gut, neurology interacts various GM. Furthermore, highlighted recent advances future prospects may require addressing research concerns about
Language: Английский
Citations
52
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Feb. 9, 2024
The human brain remains one of the greatest challenges for modern medicine, yet it is most integral and sometimes overlooked aspects medicine. consists roughly 100 billion neurons, trillion neuronal connections consumes about 20–25% body’s energy. Emerging evidence highlights that insufficient or inadequate nutrition linked to an increased risk health, mental psychological functioning compromise. A core component this relationship includes intricate dynamics brain-gut-microbiota (BGM) system, which a progressively recognized factor in sphere mental/brain health. bidirectional between brain, gut, gut microbiota along BGM system not only affects nutrient absorption utilization, but also exerts substantial influence on cognitive processes, mood regulation, neuroplasticity, other indices Neuroplasticity brain’s capacity adaptation neural regeneration response stimuli. Understanding neuroplasticity considering interventions enhance remarkable ability change through experience constitutes burgeoning area research has potential improving well-being, resilience, overall health optimal lifestyle interventions. nexus both academic clinical perspectives nutritional neuroscience emerges as potent tool patient outcomes, proactively mitigate challenges, improve management treatment existing conditions by championing health-promoting dietary patterns, rectifying deficiencies, seamlessly integrating nutrition-centered strategies into care.
Language: Английский
Citations
19
Neuropharmacology, Journal Year: 2023, Volume and Issue: 231, P. 109491 - 109491
Published: March 15, 2023
Neuroplasticity refers to the ability of brain circuits reorganize and change properties network, resulting in alterations function behavior. It is traditionally believed that neuroplasticity influenced by external stimuli, learning, experience. Intriguingly, there new evidence suggesting endogenous signals from body's periphery may play a role. The gut microbiota, diverse community microorganisms living harmony with their host, be able influence plasticity through its modulation gut-brain axis. Interestingly, maturation microbiota coincides critical periods neurodevelopment, during which neural are highly plastic potentially vulnerable. As such, dysbiosis (an imbalance composition) early life contribute disruption normal developmental trajectories, leading neurodevelopmental disorders. This review aims examine ways can affect neuroplasticity. will also discuss recent research linking gastrointestinal issues bacterial various disorders potential impact on neurological outcomes. article part Special Issue "Microbiome & Brain: Mechanisms Maladies".
Language: Английский
Citations
38
Microorganisms, Journal Year: 2023, Volume and Issue: 11(2), P. 487 - 487
Published: Feb. 15, 2023
Τhe importance of the gut microbiome and its functions has only recently been recognized researched in greater depth. The establishment human begins utero, forming adult-like phenotype first 2–3 years life. Several factors affect alter composition metabolic functions, such as early onset breastfeeding, mode delivery, antibiotic administration, or exposure to chemical substances, among others. Existing data support important connection between health status homeostasis. In cases when this balance is disturbed, several disorders may arise, inflammatory reactions that lead atopy, eczema, allergic asthma. so-called gut-brain axis refers complex biochemical pathways central nervous system gastrointestinal system. One most fascinating areas ongoing research broad spectrum neurodevelopmental (NDDs) how be associated with disorders. prevalence NDDs, autism disorder attention deficit hyperactivity disorder, increased over recent years. Whether microbiota homeostasis plays a role these not yet fully understood. aim narrative review provide an account current knowledge on linked We performed literature order identify synthesize available highlights potential association NDDs balanced terms proper function. offers promising new opportunities for future research.
Language: Английский
Citations
31
Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1560 - 1560
Published: May 27, 2023
The enteric nervous system (ENS) is a nerve network composed of neurons and glial cells that regulates the motor secretory functions gastrointestinal (GI) tract. There abundant evidence mutual communication between brain GI Dysfunction these connections appears to be involved in pathophysiology Parkinson's disease (PD). Alterations ENS have been shown occur very early PD, even before central (CNS) involvement. Post-mortem studies PD patients aggregation α-synuclein (αS) specific subtypes ENS. Subsequently, αS spreads retrogradely CNS through preganglionic vagal fibers this nerve's dorsal nucleus (DMV) other structures. Here, we highlight role pathogenesis based on observed animal models using translational perspective. While acknowledging putative microbiome gut-brain axis (GBA), review provides comprehensive view not only as "second brain", but also window into "first potentially crucial element search for new therapeutic approaches can delay cure disease.
Language: Английский
Citations
30
Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 23, 2023
The need to find new therapeutic interventions in patients diagnosed with psychiatric disorders is supported by the data suggesting high rates of relapse, chronic evolution, resistance, or lack adherence and disability. use pre-, pro-, synbiotics as add-ons management has been explored a way augment efficacy psychotropics improve chances for these reach response remission. This systematic literature review focused on tolerability psychobiotics main categories it conducted through most important electronic databases clinical trial registers, using PRISMA 2020 guidelines. quality primary secondary reports was assessed criteria identified Academy Nutrition Diabetics. Forty-three sources, mostly moderate quality, were reviewed detail, regarding assessed. Studies exploring effects mood disorders, anxiety schizophrenia spectrum substance eating attention deficit hyperactivity disorder (ADHD), neurocognitive autism (ASD) included. overall good, but evidence support their specific mixed. There have favor probiotics ADHD, ASD, also association selenium disorders. In several domains, research still an early phase development, e.g., (only three preclinical studies being found) (one identified). Although no well-defined recommendation could yet be formulated product there encouraging further research, especially if identification sub-populations that may benefit from this intervention. Several limitations field should addressed, i.e., majority finalized trials are short duration, inherent heterogeneity diversity Philae prevents generalizability results studies.
Language: Английский
Citations
23
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 21, 2024
The bidirectional communication between the gut and brain or gut-brain axis is regulated by several microbes microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, lipopolysaccharides. Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local central neuronal functions. An imbalance intestinal commensals pathobionts leads to a disruption in dysbiosis, which affects barrier integrity gut-immune neuroimmune systems. Currently, fecal transplantation (FMT) recommended for treatment of recurrent
Language: Английский
Citations
15
Children, Journal Year: 2024, Volume and Issue: 11(7), P. 796 - 796
Published: June 28, 2024
The formation of the human gut microbiome initiates in utero, and its maturation is established during first 2–3 years life. Numerous factors alter composition functions, including mode delivery, early onset breastfeeding, exposure to antibiotics chemicals, maternal stress, among others. microbiome–brain axis refers interconnection biological networks that allow bidirectional communication between brain, involving nervous, endocrine, immune systems. Evidence suggests metabolic byproducts are actively implicated regulation brain development. Any disturbance this stage may adversely affect resulting a variety neurodevelopmental disorders (NDDs). In present study, we reviewed recent evidence regarding impact on development, alongside correlation with significant NDDs, such as autism spectrum disorder, attention-deficit/hyperactivity Tourette syndrome, cerebral palsy, fetal alcohol disorders, genetic NDDs (Rett, Down, Angelman, Turner syndromes). Understanding changes provide new chances for their treatment future.
Language: Английский
Citations
12
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 20, 2024
Various microbial communities reside in the gastrointestinal tract of humans and play an important role immunity, digestion, drug metabolism, intestinal integrity, protection from pathogens. Recent studies have revealed that gut microbiota (GM) is involved communication with brain, through a bidirectional network known as gut-brain axis. This involves humoral, immunological, endocrine, neural pathways. Gut dysbiosis negatively impacts these pathways, leading to neurological complications cognitive deficits. Both pre-clinical clinical demonstrated probiotics can restore healthy GM, reduce pH, inflammation pathogenic microbes gut. Additionally, improve cell-to-cell signaling increase blood-brain-derived neurotrophic factors. Probiotics emerge potential approach for preventing managing Despite promising findings, safety concerns possible risks probiotic usage must be closely monitored addressed. review article provides brief overview significance health.
Language: Английский
Citations
11