Journal of Perinatology, Journal Year: 2023, Volume and Issue: 43(6), P. 741 - 745
Published: Feb. 22, 2023
Language: Английский
Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 424 - 424
Published: Feb. 20, 2024
Evidence shows that the gut microbiome in early life is an essential modulator of physiological processes related to healthy brain development, as well mental and neurodegenerative disorders. Here, we conduct a systematic review assessments on infants (both with conditions affect development) during first thousand days life, associated neurodevelopmental outcomes, aim investigating key players mechanisms through which affects brain. Bacteroides Bifidobacterium were non-social fear behavior, duration orientation, cognitive motricity neurotypical development. Lachnospiraceae, Streptococcus, Faecalibacterium showed variable levels influence behavior Few studies described mechanistic insights NAD salvage, aspartate asparagine biosynthesis, methanogenesis, pathways involved bile acid transformation, short-chain fatty acids production, microbial virulence genes. Further associating species gene robustness data analysis integration are required elucidate functional underlying role microbiome–gut–brain axis
Language: Английский
Citations
11
Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 97, P. 104068 - 104068
Published: May 7, 2024
Language: Английский
Citations
10
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 19 - 41
Published: Jan. 1, 2025
Language: Английский
Citations
1
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270
Published: Feb. 12, 2025
The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.
Language: Английский
Citations
1
Metabolites, Journal Year: 2022, Volume and Issue: 12(12), P. 1247 - 1247
Published: Dec. 10, 2022
The gut microbiome is a collection of microorganisms and parasites in the gastrointestinal tract. Many factors can affect this community's composition, such as age, sex, diet, medications, environmental triggers. relationship between human host microbiota crucial for organism's survival development, whereas disruption lead to various inflammatory diseases. Cannabidiol (CBD) tetrahydrocannabinol (THC) are used treat muscle spasticity associated with multiple sclerosis. It now clear that these compounds also benefit patients neuroinflammation. CBD THC treatment inflammation. significant source nutrients, including vitamins B K, which products. While play role brain bone development function, influence on gut-brain gut-bone axes extends further continues receive increasing scientific scrutiny. has been demonstrated be vital optimal functions stress suppression. Additionally, several studies have revealed developing maintaining skeletal integrity mineral density. maintenance matrix. presence actions specific T regulatory cells, formation proliferation. In addition, its metabolites prevent loss. help maintain bone's equilibrium metabolic diseases, osteoporosis. review, dual plays regulating axis impact roles discussed.
Language: Английский
Citations
31
Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2199 - 2199
Published: Aug. 31, 2023
Gut microbiota plays a critical role in physiological regulation throughout life and is specifically modified to meet the demands of individual stages during pregnancy. Maternal gut uniquely adapted pregnancy mother developing fetus. Both animal studies pregnant germ-free rodents human have supported association between composition maternal fetal development. may also contribute development gut-brain axis (GBA), which increasingly recognized for its health disease. Most consider birth as time GBA activation focus on postnatal This review focuses prenatal period impact It hypothesized that adaptation maturation postnatally. Consequently, factors affecting pregnancy, such obesity, diet, stress depression, infection, medication, affect are activity Altered gestation has been shown long-term postnatally multigenerational effects. Thus, understanding crucial managing fetal, neonatal, adult health, should be included among public priorities.
Language: Английский
Citations
21
Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2260 - 2260
Published: July 13, 2024
We conducted a 12-week randomized double-blind placebo-controlled clinical trial to investigate the potential impact of Bifidobacterium bifidum (Bf-688) supplementation on attention-deficit/hyperactivity disorder (ADHD). Children with ADHD who were already receiving stable dose methylphenidate (MPH) treatment enrolled and randomly assigned two groups: one add-on Bf-688 (daily bacterial count 5 × 109 CFUs) (n = 51) other placebo 51). All participants underwent assessments using Conners’ Continuous Performance Test (CPT) Auditory Attention (CATA). Additionally, fecal samples collected at beginning (week 0) endpoint 12). Remarkably, group supplementation, but not group, exhibited significant improvements in omission errors CPT as well Hit reaction time both CATA. Gut microbiome analysis revealed increase Firmicutes Bacteroidetes ratio (F/B ratio) only group. Furthermore, we identified negative correlations between N-Glycan biosynthesis Our results demonstrate that probiotic supplement can enhance neuropsychological performance children ADHD, possibly by altering composition gut microbiota, ultimately leading reduced biosynthesis.
Language: Английский
Citations
6
Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1084 - 1084
Published: Aug. 29, 2024
According to the DSM-5, neurodevelopmental disorders represent a group of heterogeneous conditions, with onset during developmental period, characterized by an alteration communication and social skills, learning, adaptive behavior, executive functions, psychomotor skills. These deficits determine impairment personal, social, scholastic, or occupational functioning. Neurodevelopmental are increased incidence multifactorial etiology, including genetic environmental components. Data largely explain role factors, also through epigenetic modifications such as DNA methylation miRNA. Despite nutritional factors play significant in pathophysiology these disorders, both prenatal postnatal underscoring that control modifiable could decrease disorders. The preventive nutrition is widely studied regards many chronic diseases, diabetes, hypertension, cancer, but actually we know effects on embryonic brain development influence preconceptional predisposition various pathologies. not limited only correct caloric intake good BMI, rather adequate balanced macro micronutrients, type diet, other elements exposure heavy metals. This review represents analysis literature physiopathological mechanisms which food influences our state health, especially age (from birth adolescence), changes, underlying how controlling should improve mothers' significantly reduce risk offspring. We searched key words "maternal disorders" Pubmed Google Scholar, selecting main reviews excluding individual cases. Therefore, nutrigenetics nutrigenomics teach us importance personalized for health. So future perspectives may include well-established reference values order mothers integration.
Language: Английский
Citations
6
Gastrointestinal Disorders, Journal Year: 2024, Volume and Issue: 6(4), P. 801 - 815
Published: Sept. 27, 2024
The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These involve production of metabolites, signaling molecules, and direct communication cells, which modulate hormone secretion activity. As result, can exert neuroendocrine effects contribute to metabolic regulation, adiposity, appetite control. Additionally, influences reproductive altering levels sex hormones such as estrogen testosterone, potentially contributing conditions like polycystic ovary syndrome (PCOS) hypogonadism. Given these roles, targeting offers researchers clinicians novel opportunities improve overall well-being. Probiotics,
Language: Английский
Citations
6
Animals, Journal Year: 2023, Volume and Issue: 13(9), P. 1458 - 1458
Published: April 25, 2023
The literature has identified poor nutrition as the leading factor in manifestation of many behavioural issues animals, including aggression, hyperalertness, and stereotypies. Literature focused on all species interest consistently reported that although there were no significant differences richness specific bacterial taxa microbiota individual subjects with abnormal behaviour (termed alpha diversity), was variability diversity between these compared to controls beta diversity). As seen humans mental disorders, animals exhibiting often have an enrichment pro-inflammatory lactic acid-producing bacteria a reduction butyrate-producing bacteria. It is evident from association exists gut (and by extension, concurrent production microbial metabolites) phenotypes across various species, pigs, dogs, horses. Similar population changes are also human health patients. However, insufficient data identify this cause or effect. This review provides testable hypotheses for future research establish causal relationships offering promising potential development novel therapeutic and/or preventative interventions aimed at restoring healthy gut-brain-immune axis mitigate and, turn, improve health, performance, animals.
Language: Английский
Citations
13