PubMed, Journal Year: 2024, Volume and Issue: 27(8), P. 1005 - 1014
Published: Jan. 1, 2024
Early effective treatment and appropriate coverage are vital for full-thickness wounds. Amnion membrane-derived products have recently emerged in tissue engineering. However, the optimal concentration, carrier controlled release, handling remained challenges. This study aims to develop optimize an
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30
Published: April 23, 2024
Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.
Language: Английский
Citations
22
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 707 - 707
Published: May 30, 2024
Mesenchymal stem cells (MSCs) have emerged as a promising approach for drug delivery strategies because of their unique properties. These include cell membrane-coated nanoparticles, cell-derived extracellular vesicles, immunomodulatory effects, cell-laden scaffolds, and scaffold-free sheets. MSCs offer advantages such low immunogenicity, homing ability, tumor tropism, making them ideal targeted systems. Stem vesicles gained attention immune properties tumor-homing abilities, presenting potential solution challenges. The relationship between MSC-based the self-renewal differentiation capabilities lies in engineered to serve effective carriers therapeutic agents while maintaining intrinsic exhibit potent immunosuppressive functions strategies. EVs immunogenicity strong tissue repair regeneration. Scaffold-free sheets represent cutting-edge regenerative medicine, offering versatile platform engineering regeneration across different medical specialties. shown great clinical applications medicine ability differentiate into various types, secrete bioactive factors, modulate responses. Researchers are exploring these innovative approaches enhance efficiency effectiveness treating diseases.
Language: Английский
Citations
14
Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Citations
2
Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(10), P. 2189 - 2189
Published: Oct. 14, 2022
Introduction: this study was conducted to investigate the osteogenic ability of periodontal ligament stem cells (PDLSCs) derived exosomes (PDLSCs-Exos) and effect PDLSCs-Exos with hydrogel on alveolar bone defect repairment in rat. Methods: PDLSCs were obtained through primary cell culture, purified by ultracentrifugation method. The CCK-8 kit ALP staining used explore promoting proliferation differentiation marrow mesenchymal (BMSCs). In vivo, models made mesial bilateral maxillary first molars rats. MicroCT, HE staining, Masson analyze new at Results: successfully extracted. results showed significantly promoted BMSCs. vivo experiment revealed that compared control group group, rats more formation defects. Conclusion: Periodontal from demonstrated delivered for repairing defects initial stage.
Language: Английский
Citations
39
Tissue Engineering and Regenerative Medicine, Journal Year: 2023, Volume and Issue: 20(6), P. 981 - 992
Published: Sept. 12, 2023
Language: Английский
Citations
14
Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(5), P. 1479 - 1496
Published: March 1, 2024
Language: Английский
Citations
6
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 476 - 476
Published: July 18, 2024
Stroke remains the second leading cause of death and a major disability worldwide, significantly impacting individuals, families, healthcare systems. This neurological emergency can be triggered by ischemic events, including small vessel arteriolosclerosis, cardioembolism, large artery atherothromboembolism, as well hemorrhagic incidents resulting from macrovascular lesions, venous sinus thrombosis, or vascular malformations, to significant neuronal damage. The resultant motor impairment, cognitive dysfunction, emotional disturbances underscore urgent need for effective therapeutic interventions. Recent advancements in biomaterials, particularly hydrogels, offer promising new avenues stroke management. Hydrogels, composed three-dimensional networks hydrophilic polymers, are notable their ability absorb retain substantial amounts water. Commonly used polymers hydrogel formulations include natural like alginate, chitosan, collagen, synthetic such polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyacrylamide. Their customizable characteristics—such porosity, swelling behavior, mechanical strength, degradation rates—make hydrogels ideal biomedical applications, drug delivery, cell tissue engineering, controlled release agents. review comprehensively explores hydrogel-based approaches both therapy, elucidating mechanisms which provide neuroprotection. It covers application delivery systems, role reducing inflammation secondary injury, potential support neurogenesis angiogenesis. also discusses current technology challenges translating these innovations research into clinical practice. Additionally, it emphasizes limited number trials utilizing therapies addresses associated limitations constraints, underscoring further this field.
Language: Английский
Citations
5
Cellular Reprogramming, Journal Year: 2023, Volume and Issue: 25(1), P. 32 - 44
Published: Jan. 31, 2023
Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. Under appropriate environmental cues, multipotency enables MSCs to serve as progenitors for several lineage-specific, differentiated cell types. In vitro expansion and differentiation of give the opportunity obtain hardly available somatic cells, such neurons. The neurogenic potential makes them a promising, autologous source restore damaged tissue such, they have received much attention field regenerative medicine. Several stem pool candidates been studied thus far, but only few showed potential. Due their embryonic ontology, residing stroma dental pulp chamber an exciting neural differentiation. this study, we review key properties (DPSCs), with particular focus on Moreover, summarize various presently methods used human DPSCs also emphasizing difficulties reproducibly high production cells. We postulate that because very close ontology lineages, may excellent targets neuronal even direct reprogramming.
Language: Английский
Citations
10
Stem Cells International, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Pulmonary fibrosis (PF) is a lethal pathological change of fibrotic interstitial lung diseases (ILDs) with abundant fibroblasts proliferation after severely or continually alveolar epithelial cells (AECs) injury. Barely therapies are helpful for PF. Here we use bleomycin intratracheally injection to model PF without human umbilical cord–mesenchymal stem (hUC–MSCs) and/or nintedanib intervention. RNA‐Seq followed real‐time PCR and western blot were used find out the specific possible mechanisms effects hUC–MSC on Immunostaining, cell counting kit‐8 (CCK‐8), 5‐bromo‐2′‐deoxyuridine (BrdU) incorporation assay detect in vivo vitro separately. We found that hUC–MSCs alone had prophylactic, but not therapeutic induced mouse Nevertheless, combination therapy low‐dose significantly improved survival reversed mice. The factors secreted by have promotional both AECs. Nintedanib could hamper facilitation caused influence AECs proliferation, which might be related inhibition FGFR, PDGFR, VEGFR activities. Our study indicated should promising strategy
Language: Английский
Citations
0