Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Dec. 31, 2024
Liver
cancer,
especially
hepatocellular
carcinoma
(HCC),
is
one
of
the
most
common
malignant
tumors
worldwide,
and
its
high
mortality
rate
treatment
difficulty
have
always
been
major
challenges
faced
by
medical
community.
With
continuous
development
biotechnology,
stem
cell
research
has
shown
great
potential
hope
in
liver
cancer
treatment.
This
review
provides
a
brief
overview
importance
cells
research,
including
identification
(LCSCs),
molecular
maintenance
mechanisms
stemness
LCSCs,
targeted
therapy
strategies,
as
well
therapy,
proposing
future
directions.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
6(8)
Published: July 29, 2024
Abstract
Arteriosclerosis
(AS)
presents
a
significant
global
health
challenge,
demanding
innovative
therapeutic
strategies.
This
review
explores
the
potential
of
nanoparticles
(NPs)
and
mesenchymal
stem
cells
(MSCs)
as
promising
modalities
for
treating
AS.
NPs
enable
targeted
drug
delivery,
while
MSCs
possess
immunomodulatory
regenerative
capabilities.
We
discuss
recent
advances
in
NP-based
delivery
systems
tailored
AS
treatment
highlight
MSCs’
roles
modulating
inflammation
promoting
vascular
repair.
Additionally,
we
examine
synergistic
effects
combining
enhanced
outcomes.
Furthermore,
this
paper
provides
insights
into
targeting
endothelial
cells,
T-cells,
macrophages,
lipid
levels,
plaques
using
MSCs.
It
also
reviews
various
types
metal-based
non-metallic
utilized
therapy.
comprehensive
overview
underscores
synergies
between
cardiovascular
disease
therapy,
emphasizing
need
further
research
to
fully
realize
their
implications.
Graphical
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 5, 2025
Pulmonary
fibrosis
(PF)
is
a
common
and
multidimensional
devastating
interstitial
lung
disease.
The
development
of
novel
more
effective
interventions
for
PF
an
urgent
clinical
need.
A
previous
study
has
found
that
miR-181a-5p
plays
important
role
in
the
PF,
human
amniotic
mesenchymal
stem
cells
(hAMSCs)
exert
potent
therapeutic
potential
on
PF.
However,
whether
hAMSCs
act
by
delivering
its
detailed
mechanism
still
remain
unknown.
Thus,
this
was
designed
to
investigate
underlying
possible
bleomycin
(BLM)-induced
mouse
model,
co-culture
system
A549
epithelial
transition
(EMT)
focusing
effects
collagen
deposition,
EMT,
cell
cycle
regulation.
with
different
expression
levels
were
constructed.
BLM
(4
mg/kg)
used
create
while
TGF-β1
induce
construct
EMT
model.
Furthermore,
deposition
during
assessed
vivo
vitro.
We
exerted
anti-fibrotic
effect
BLM-induced
Moreover,
also
protective
TGFβ1-induced
ameliorated
promoting
proliferation,
reducing
apoptosis,
attenuating
through
paracrine
effects.
regulated
targeting
TGFBR1.
Our
findings
reveal
first
time
inhibit
EMT.
Mechanistically,
hMASCs
achieved
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 281 - 281
Published: Feb. 20, 2025
The
blood–brain
barrier
(BBB)
is
a
critical
structure
that
maintains
brain
homeostasis
by
selectively
regulating
nutrient
influx
and
waste
efflux.
Not
surprisingly,
it
often
compromised
in
neurodegenerative
diseases.
In
addition
to
its
involvement
these
pathologies,
the
BBB
also
represents
significant
challenge
for
drug
delivery
into
central
nervous
system.
Nanoparticles
(NPs)
have
been
widely
explored
as
carriers
capable
of
overcoming
this
effectively
transporting
therapies
brain.
However,
their
potential
directly
address
ameliorate
dysfunction
has
received
limited
attention.
review,
we
examine
how
NPs
enhance
across
treat
diseases
explore
emerging
strategies
restore
integrity
vital
structure.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 29, 2024
The
most
prevalent
and
harmful
injuries
are
burns,
which
still
a
major
global
health
problem.
Burn
can
cause
issues
because
they
boost
the
inflammatory
metabolic
response,
organ
malfunction
systemic
failure.
On
other
hand,
burn
wound
infection
creates
an
environment
that
is
conducive
to
growth
of
bacteria
might
put
patient
at
risk
for
sepsis.
In
addition,
scarring
unavoidable,
this
results
in
patients
having
functional
cosmetic
issues.
Wound
healing
amazing
phenomenon
with
complex
mechanism
deals
different
types
cells
biomolecules.
Cell
therapy
using
stem
one
challenging
treatment
methods
accelerates
wounds.
Since
2000,
use
mesenchymal
(MSCs)
regenerative
medicine
has
increased.
They
be
extracted
from
various
tissues,
such
as
bone
marrow,
fat,
umbilical
cord,
amniotic
membrane.
According
studies,
cell
wounds
increases
angiogenesis,
anti-inflammatory
properties,
slows
progression
fibrosis,
excellent
ability
differentiate
regenerate
damaged
tissue.
Figuring
out
main
preclinical
clinical
problems
stop
people
MSCs
then
suggesting
right
ways
improve
could
help
show
benefits
move
cell-based
forward.
This
review's
objective
was
assess
therapy's
contribution
promotion
healing.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(15), P. 11902 - 11922
Published: Jan. 1, 2025
Graphene
oxide
(GO)
and
reduced
graphene
(rGO)
with
gold
nanoparticles
(GNPs)
enhance
phototherapy,
leveraging
the
NIR-I
NIR-II
optical
biological
windows
for
improved
tissue
penetration
targeted
cancer
treatment.
