Cardiometry,
Journal Year:
2022,
Volume and Issue:
24, P. 134 - 144
Published: Nov. 30, 2022
The
aim
hereof
is
to
develop
a
method
for
revealing
the
properties
of
mitochondria
isolated
from
melanoma
skin
form
tumor
nodules
in
body
mice
parenteral
transplantation
mitochondria.
Materials
and
methods.
We
used
experimental
animals
according
following
design:
intraperitoneal
with
B16/F10
Balb/c
Nude
male
mice,
n
=
8.
All
underwent
one-time
based
on
5.2
mg
protein
per
1
animal
0.4
ml
saline
solution.
were
as
references,
which
transplanted
solution
once
into
muscle
intraperitoneally.
Morphological
examination
sections
internal
organs
foci
was
carried
out
after
specimen
paraffin
embedding
hematoxylin-eosin
staining
microscopy
specimens
Axiovert
(Carl
44
Zeiss,
Germany)
Axiovision
4
image
visualization
software
Germany).
Results.
Upon
autopsies
100%
2
weeks
experiment
total
damage
by
revealed.
morphological
B16
demonstrated
lesion
visceral
tissue
abdominal
organs.
Conclusion.
Thus,
use
C57BL/6
caused
growth
development
body.
Our
study
revealed
previously
unknown
melanoma,
consisting
their
ability
induce
upon
cell
transplantation.
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(4), P. 2349 - 2422
Published: April 6, 2023
Mitochondria
are
well
known
as
organelles
responsible
for
the
maintenance
of
cellular
bioenergetics
through
production
ATP.
Although
oxidative
phosphorylation
may
be
their
most
important
function,
mitochondria
also
integral
synthesis
metabolic
precursors,
calcium
regulation,
reactive
oxygen
species,
immune
signaling,
and
apoptosis.
Considering
breadth
responsibilities,
fundamental
metabolism
homeostasis.
Appreciating
this
significance,
translational
medicine
has
begun
to
investigate
how
mitochondrial
dysfunction
can
represent
a
harbinger
disease.
In
review,
we
provide
detailed
overview
metabolism,
bioenergetics,
dynamics,
autophagy,
damage-associated
molecular
patterns,
mitochondria-mediated
cell
death
pathways,
at
any
these
levels
is
associated
with
disease
pathogenesis.
Mitochondria-dependent
pathways
thereby
an
attractive
therapeutic
target
ameliorating
human
Life Sciences,
Journal Year:
2024,
Volume and Issue:
342, P. 122510 - 122510
Published: Feb. 20, 2024
Rac1
is
a
member
of
the
Rho
GTPase
family
which
plays
major
roles
in
cell
mobility,
polarity
and
migration,
as
fundamental
regulator
actin
cytoskeleton.
Signal
transduction
by
occurs
through
interaction
with
multiple
effector
proteins,
its
activity
regulated
guanine
nucleotide
exchange
factors
(GEFs)
GTPase-activating
proteins
(GAPs).
The
small
protein
mainly
anchored
to
inner
side
plasma
membrane
but
it
can
be
found
endocellular
compartments,
notably
endosomes
nuclei.
localizes
also
into
mitochondria
where
contributes
regulation
mitochondrial
dynamics,
including
both
mitobiogenesis
mitophagy,
addition
signaling
processes
via
different
partners,
such
proapoptotic
Bcl-2
chaperone
sigma-1
receptor
(σ-1R).
form
(mtRac1)
has
been
understudied
thus
far,
essential
nuclear
or
forms,
implication
oxidative
stress
DNA
damages.
subject
diverse
post-translational
modifications,
geranylgeranylation
importantly
import
anchorage
membranes.
In
addition,
translocation
other
p53.
localization
functions
are
discussed
here,
context
human
diseases
cancers.
Inhibitors
have
identified
(NSC-23766,
EHT-1864)
some
being
developed
for
treatment
cancer
(MBQ-167)
central
nervous
system
(JK-50561).
Their
effects
on
mtRac1
warrant
further
investigations.
An
overview
provided
here.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(2)
Published: Feb. 20, 2024
Mitochondrial
transfer
plays
an
important
role
in
various
diseases,
and
many
mitochondrial
biological
functions
can
be
regulated
by
HMGB1.
To
explore
the
of
hepatocellular
carcinoma
(HCC)
its
relationship
with
HMGB1,
field
emission
scanning
electron
microscopy,
immunofluorescence,
flow
cytometry
were
used
to
detect
between
HCC
cells.
We
found
that
cells
was
confirmed
using
tunnel
nanotubes
(TNTs).
The
mitochondria
from
highly
invasive
less
could
enhance
migration
invasion
ability
latter.
hypoxic
conditions
increased
Then
mechanism
identified
co-immunoprecipitation,
luciferase
reporter
assay,
chromatin
immunoprecipitation.
RHOT1,
a
transport
protein,
promoted
metastasis
during
this
process.
Under
hypoxia,
HMGB1
further
RHOT1
expression
increasing
NFYA
NFYC
subunits
NF-Y
complex.
RAC1,
protein
associated
TNTs
formation,
development.
Besides,
RAC1
aggregation
cell
membrane
under
hypoxia.
Finally,
changes
significance
related
molecules
clinical
samples
analyzed
bioinformatics
tissue
microarray
analyses.
patients
high
or
exhibited
relatively
shorter
overall
survival
period.
In
conclusion,
conditions,
formation-related
RAC1.
Biomarker Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Oct. 5, 2023
Abstract
Mitochondria
are
energy-generated
organelles
and
take
an
important
part
in
biological
metabolism.
could
be
transferred
between
cells,
which
serves
as
a
new
intercellular
communication.
Mitochondrial
transfer
improves
mitochondrial
defects,
restores
the
functions
of
recipient
maintains
high
metabolic
requirements
tumor
cells
well
drug
resistance.
In
recent
years,
it
has
been
reported
bone
marrow
microenvironment
hematological
malignant
play
critical
role
disease
progression
resistance
during
chemotherapy.
this
review,
we
discuss
patterns
mechanisms
on
their
engagement
different
pathophysiological
contexts
outline
latest
knowledge
transport
mitochondria
malignancies.
Besides,
briefly
caused
by
Our
review
demonstrates
theoretical
basis
for
prospective
therapeutic
target
to
increase
treatment
efficiency
malignancies
improve
prognosis
patients.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3783 - 3783
Published: April 17, 2025
Male
infertility
is
often
linked
to
sperm
quality
issues;
however,
the
mechanisms
behind
these
alterations
remain
unclear
in
certain
contexts.
This
study
investigates
impact
of
anomalous
Rho
GTPase
activation—a
process
triggered
by
bacterial
toxins—on
human
structure
and
function.
Human
spermatozoa
were
exposed
vitro
a
activator
derived
from
Escherichia
coli
under
both
capacitating
non-capacitating
conditions.
The
results
showed
increased
RhoA
activity
conditions,
without
affecting
viability
or
mitochondrial
membrane
potential.
However,
progressive
motility
decreased
across
while
non-progressive
acrosome
reaction
rates
increased.
Additionally,
intracellular
calcium
levels
rose
exclusively
Structural
analysis
revealed
an
increase
abnormal
morphology,
particularly
vacuoles
head.
These
findings
highlight
that
activation
disrupts
essential
processes
like
capacitation,
which
are
crucial
for
successful
fertilization.
provides
novel
insights
into
how
infections
may
induce
damage,
proposing
could
serve
as
biomarker
evaluating
cases
urogenital
infections.
Understanding
improve
diagnostic
therapeutic
approaches
male
associated
with
pathogens.
Cancer and Metastasis Reviews,
Journal Year:
2024,
Volume and Issue:
43(4), P. 1419 - 1443
Published: Sept. 23, 2024
Mitochondria
are
central
actors
in
diverse
physiological
phenomena
ranging
from
energy
metabolism
to
stress
signaling
and
immune
modulation.
Accumulating
scientific
evidence
points
the
critical
involvement
of
specific
mitochondrial-associated
events,
including
mitochondrial
quality
control,
intercellular
transfer,
genetics,
potentiating
metastatic
cascade
neoplastic
cells.
Furthermore,
numerous
recent
studies
have
consistently
emphasized
highly
significant
role
mitochondria
play
coordinating
regulation
tumor-infiltrating
cells
immunotherapeutic
interventions.
This
review
provides
a
comprehensive
rigorous
scholarly
investigation
this
subject
matter,
exploring
intricate
mechanisms
by
which
contribute
tumor
metastasis
examining
progress
mitochondria-targeted
cancer
therapies.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
208, P. 107382 - 107382
Published: Aug. 30, 2024
It
is
now
recognized
that
tumors
are
not
merely
masses
of
transformed
cells
but
intricately
interconnected
with
healthy
in
the
tumor
microenvironment
(TME),
forming
complex
and
heterogeneous
structures.
Recent
studies
discovered
cancer
can
steal
mitochondria
from
to
empower
themselves,
while
reducing
functions
their
target
organ.
Mitochondrial
transfer,
i.e.
intercellular
movement
mitochondria,
recently
emerging
as
a
novel
process
biology,
contributing
growth,
metastasis,
resistance
therapy
by
shaping
metabolic
landscape
microenvironment.
This
review
highlights
influence
transferred
on
bioenergetics,
redox
balance
apoptotic
resistance,
which
collectively
foster
aggressive
phenotype.
Furthermore,
therapeutic
implications
mitochondrial
transfer
discussed,
emphasizing
potential
targeting
these
pathways
overcome
drug
improve
treatment
efficacy.
