Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder DOI Creative Commons
Jinjing Hu,

Jia Fu,

Yuxin Cai

et al.

Experimental Biology and Medicine, Journal Year: 2024, Volume and Issue: 249

Published: June 27, 2024

Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) related immune cells NP major depressive disorder (MDD) to determine whether they have pathological molecular mechanisms. MDD expression data was downloaded from Gene Expression Omnibus (GEO) database. Common differentially expressed (Co-DEGs) for were extracted nodes mined. Co-DEGs, genes, analyzed Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment. Finally, nodes, obtain Co-hub genes. We plotted Receiver operating characteristic (ROC) curves evaluate diagnostic impact on NP. also immune-infiltrating cell component ssGSEA relationship. For GO KEGG enrichment analyses, 93 Co-DEGs associated with biological processes (BP), such as fibrinolysis, composition (CC), tertiary granules, pathways, complement, coagulation cascades. A differential gene analysis revealed significant differences between ANGPT2, MMP9, PLAU, TIMP2. There some accuracy in diagnosis based ANGPT2 MMP9. Analysis components indicated an abundance activated dendritic cells, effector memory CD8 + T B regulatory both groups, statistically significant. summary, 6 4 types MDD. Further studies are needed role these potential markers or therapeutic targets

Language: Английский

Targeting TNF-α: An immunotherapeutic approach for alleviating neuropathic pain DOI
Mario García‐Domínguez

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biochemical strategies for opioid-sparing pain management in the operating room DOI
Fatemeh Hosseinzadeh, Alireza Nourazarian

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101927 - 101927

Published: Jan. 25, 2025

Language: Английский

Citations

0
NGF in Neuropathic Pain: Understanding Its Role and Therapeutic Opportunities DOI Creative Commons
Mario García‐Domínguez

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 93 - 93

Published: Jan. 31, 2025

Nerve growth factor (NGF) is one of the essential components that have been implicated in pathophysiology neuropathic pain, a condition develops following nerve injury or dysfunction. This neurotrophin critical for survival and maintenance sensory neurons, its dysregulation has sensitization pain pathways. NGF interacts with receptor TrkA p75NTR to activate intracellular signaling pathways associated nociception emergence allodynia hyperalgesia. Therapeutic approaches employing neutralizing antibodies molecule inhibitors highly effective at both preclinical clinical levels, hence giving hope again use as an important biomarker therapeutic target management pain. By exploiting unique properties interactions within nervous system, new modalities could be designed enhance efficacy while minimizing side effects. In conclusion, taking advantage multifaceted dynamics provide therapies finally respond unmet needs patients experiencing

Language: Английский

Citations

0
Magnetic Field-Responsive Nanodrug to Regulate TRPV1 Pain Receptor DOI

Athena Santi,

Nicolás Muzzio, Amanda Gomez

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

0
A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy patients DOI Creative Commons
Anna Maxion, Ekaterina Kutafina, Maike F. Dohrn

et al.

Frontiers in Computational Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Dec. 14, 2023

Objective Patients with small fiber neuropathy (SFN) suffer from neuropathic pain, which is still a therapeutic problem. Changed activation patterns of mechano-insensitive peripheral nerve fibers (CMi) could cause pain. However, there sparse knowledge about mechanisms leading to CMi dysfunction since it difficult dissect specific molecular in humans. We used an in-silico model elucidate causes as observed single recordings (microneurography) SFN patients. Approach analyzed microneurography data 97 CMi-fibers healthy individuals and 34 patients identify activity-dependent changes conduction velocity. Using the NEURON environment, we adapted biophysical realistic preexisting CMi-fiber ion channels described by Hodgkin-Huxley dynamics for identifying those changes. Via grid search optimization, assessed interplay between different channels, Na-K-pump, resting membrane potential. Main results Changing channel conductance, Na-K-pump or potential individually not sufficient reproduce unchanged velocity slowing quicker normalization after stimulation microneurography. identified best combination mechanisms: increased conductance potassium delayed-rectifier decreased depolarized When unchanged, opposite generate same effect. Significance Our study suggests that one mechanism accounts pain-relevant CMi-fibers, but mechanisms. A potential, previously leads contribution Na-K-pump. Thus, when searching targets treatment combinations several molecules should be regarded.

Language: Английский

Citations

8
Pregabalin-Induced Parkinsonism: Case Report and Review of the Literature DOI

Hossam Tharwat Ali,

Sara Abdelhameed Khalil,

Ana Letícia Fornari Caprara

et al.

Journal of Pharmacy Practice, Journal Year: 2024, Volume and Issue: 37(5), P. 1220 - 1224

Published: April 11, 2024

Pregabalin is an anti-epileptic drug approved for the treatment of neuropathic pain and focal-onset seizures. In a few cases, pregabalin was associated with parkinsonism. We present case 48-year-old female who had hypertension on losartan 50 mg/daily. Her general practitioner prescribed 150 mg/daily fibromyalgia-related pain. The subject doubled dosage without medical advice. After 5 days increased dosage, she started to experience difficulty slowness in movement resting tremors. Neuroimaging, electrodiagnostic studies, laboratory exams were unremarkable. Secondary parkinsonism suspected, so discontinued. fully recovered within 7 days. To authors’ knowledge, only 6 cases pregabalin-induced reported literature. discontinuation most common management. All individuals after withdrawal. mechanism not understood.

Language: Английский

Citations

2
Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential DOI Creative Commons
Shijia Li,

Weini Li,

Naseeb Kaur Malhi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5471 - 5471

Published: Nov. 20, 2024

Cannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as promising therapeutic agent with diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option the clinic. Recent research shed light on CBG's intriguing molecular mechanisms, highlighting to modulate multiple physiological processes. This review delves into current understanding interactions and explores power alleviate various conditions, including cancer, metabolic, pain, inflammatory disorders, amongst others. We discuss how interacts endocannabinoid system other key signaling pathways, such CB1, CB2, TPR channels, α2-adrenoceptor, potentially influencing inflammation, neurodegeneration, ailments. Additionally, we highlight ongoing efforts aimed at elucidating full spectrum safety profile clinical settings. Through this comprehensive analysis, aim provide deeper role promoting human health pave way for future endeavors.

Language: Английский

Citations

2
Synthesis and Characterization of Chitosan Acetylcholine Nanoparticles for Neural Disorders Associated with Cancer Treatment DOI
Mamilla Ravi Sankar, R. Karthikeyan,

S. Vigneshkumar

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2023, Volume and Issue: 33(8), P. 2465 - 2484

Published: May 13, 2023

Language: Английский

Citations

6
Quantitative Sensory Testing to Characterize Sensory Changes in Hidradenitis Suppurativa Skin Lesions DOI
A. Alsouhibani,

Patrick Speck,

Emily Cole

et al.

JAMA Dermatology, Journal Year: 2023, Volume and Issue: 159(10), P. 1102 - 1102

Published: Sept. 13, 2023

Pain is the most impactful symptom in patients with hidradenitis suppurativa (HS). Characterization of sensory profiles may improve understanding pain mechanisms HS and facilitate identification effective management strategies.

Language: Английский

Citations

6
Neurophysiology of corneal neuropathic pain and emerging pharmacotherapeutics DOI Creative Commons
Kofi Asiedu

Journal of Neuroscience Research, Journal Year: 2023, Volume and Issue: 102(1)

Published: Dec. 28, 2023

Abstract The altered activity generated by corneal neuronal injury can result in morphological and physiological changes the architecture of synaptic connections nervous system. These alter sensitivity neurons (both second‐order higher‐order projection) projecting pain signals. A complex process involving different cell types, molecules, nerves, dendritic cells, neurokines, neuropeptides, axon guidance molecules causes a high level sensory rearrangement, which is germane to all phases pathomechanism neuropathic pain. Immune cells migrating region nerve assist generation secreting neurokines that ensure depolarization. Furthermore, excitability central pathway perpetuated local activation microglia trigeminal ganglion alterations descending inhibitory modulation for arriving from Corneal may be facilitated dysfunctional structures somatosensory system due lesion, synaptogenesis, or genetic abnormality. Understanding these important pathways will provide novel therapeutic insight.

Language: Английский

Citations

6