Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 29, 2023
Abstract
Small
cell
lung
cancer
(SCLC)
is
a
highly
malignant
with
poor
prognosis.
Therefore,
more
accurate
models
to
identify
high-risk
patients
are
essential
for
facilitating
personalized
management
of
SCLC.
Immunogenic
death
(ICD)
process
that
stimulates
robust
anti-tumor
immune
responses
and
holds
promising
implications
treatment.
However,
the
expression
ICD-related
genes
in
SCLC
their
correlations
prognosis
remain
unclear.
In
this
study,
we
employed
series
bioinformatic
machine
learning
approaches
establish
an
risk
score
(ICDRS)
classified
into
low-
or
subgroups.
Patients
subgroup
exhibited
significantly
lower
survival
probabilities,
prognostic
value
ICDRS
was
validated
independent
cohorts.
Furthermore,
GSEA
tumor
microenvironment
(TME)
analysis
indicated
proliferation
cancer-associated
fibroblasts
were
enriched
subgroup,
while
immune-realted
scores
subgroup.
Overall,
could
serve
as
useful
biomarker
overall
(OS)
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: May 18, 2024
Abstract
Substantial
progress
in
research
on
sperm
cryopreservation
has
occurred
since
the
twentieth
century,
especially
focusing
improving
freezing
procedures
and
optimizing
semen
extenders.
However,
cellular
biological
mechanisms
of
damage
are
still
unclear,
which
greatly
restricts
promotion
development
cryopreservation.
An
essential
component
is
occurrence
cell
death.
Considering
existence
multiple
types
death
pathways,
this
review
discusses
connections
between
characteristics
regulated
(e.g.,
apoptosis
ferroptosis),
accidental
intracellular
ice
crystals)
with
explores
possible
future
directions
field.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(12)
Published: Dec. 19, 2023
Abstract
Glutathione
synthetase
(GSS)
catalyzes
the
final
step
in
synthesis
of
glutathione
(GSH),
a
well-established
antioxidant.
Research
on
specific
roles
Gss
gene
during
spermatogenesis
remains
limited
due
to
intricate
structure
testis.
In
this
study,
we
identified
pachytene
spermatocytes
as
primary
site
GSS
expression
and
generated
mouse
model
with
postnatal
deletion
using
Stra8-Cre
(S8)
investigate
role
germ
cells.
The
impact
knockout
reducing
male
fertility
is
age-dependent
caused
by
ferroptosis
2-month-old
S8/
−/−
mice
exhibited
normal
fertility,
compensatory
increase
GPX4,
which
prevented
accumulation
ROS.
With
aging,
there
was
decline
GPX4
an
ALOX15
levels
observed
8-month-old
mice,
resulting
ROS,
lipid
peroxidation,
ultimately
testicular
ferroptosis.
We
found
that
did
not
affect
spermatogonia,
but
meiosis
disruption
acrosome
heterotopia.
Then
aberrant
sperm
showed
lower
concentration
abnormal
morphology,
leading
reduced
fertility.
Furthermore,
these
injuries
could
be
functionally
rescued
inhibiting
through
intraperitoneal
injection
GSH
or
Fer-1.
summary,
cells
play
crucial
resistance
oxidative
stress
injury
aged
mice.
Our
findings
deepen
understanding
suggest
may
potential
strategy
for
treatment
infertility.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Sept. 28, 2023
Ferroptosis
is
a
type
of
programmed
cell
death
mediated
by
iron-dependent
lipid
peroxidation
that
leads
to
excessive
in
different
cells.
distinct
from
other
forms
and
associated
with
various
diseases.
Iron
essential
for
spermatogenesis
male
reproductive
function.
Therefore,
it
not
surprising
new
evidence
supports
the
role
ferroptosis
testicular
injury.
Although
molecular
mechanism
which
induces
disease
unknown,
several
genes
pathways
have
been
linked
dysfunction.
In
this
review,
we
discuss
iron
metabolism,
ferroptosis,
related
regulatory
pathways.
addition,
analyze
endogenous
exogenous
factors
terms
metabolism
dysfunction,
as
well
summarize
relationship
between
Finally,
potential
strategies
target
treating
diseases
provide
directions
preventing
Cells,
Journal Year:
2024,
Volume and Issue:
13(17), P. 1490 - 1490
Published: Sept. 5, 2024
This
study
aims
to
investigate
the
role
of
ferroptosis,
an
iron-dependent
form
regulated
cell
death,
in
male
infertility.
The
motivation
behind
this
research
stems
from
increasing
recognition
oxidative
stress
and
iron
metabolism
dysregulation
as
critical
factors
reproductive
health.
In
study,
28
infertile
patients
(grouped
by
presence
urogenital
infections
or
varicocele)
19
fertile
men
were
selected.
Spermiograms
performed
light
microscopy
(WHO,
2021).
Testosterone,
ferritin,
transferrin-bound
iron,
transferrin,
F2-isoprostanes
(F2-IsoPs)
detected
seminal
plasma.
Glutathione
peroxidase
4
(GPX4)
acyl
coenzyme
A
synthetase
long
chain
family
member
(ACSL4)
also
assessed
sperm
cells
using
enzyme-linked
immunosorbent
assays
(ELISA).
All
variables
correlated
(statistically
significant
Spearman’s
rank
correlations)
whole
population,
then
comparison
between
different
groups
carried
out.
Seminal
ferritin
transferrin
positively
with
F2-IsoPs,
which
had
positive
correlations
ACSL4
cells.
Ferritin
negatively
parameters.
No
correlation
was
for
GPX4.
Comparing
three
examined
groups,
elevated
levels
observed
varicocele;
GPX4
similar
groups.
These
results
suggested
a
mechanism
identified
increased
occurrence
lipid
peroxidation.
Such
events
appear
be
GPX4-independent
pathologies
such
varicocele
infections.
The World Journal of Men s Health,
Journal Year:
2024,
Volume and Issue:
42
Published: Jan. 1, 2024
Ferroptosis
is
a
type
of
iron-dependent
regulated
cell
death
characterized
by
increased
bioavailability
redox-active
iron,
loss
GPX4
antioxidant
capacity,
and
oxidation
polyunsaturated
fatty
acid-containing
phospholipids
mediated
reactive
oxygen
species
(ROS).
The
aim
this
study
was
to
evaluate
the
effect
oxidative
stress
induced
arachidonic
acid
(AA)
on
ferroptotic
in
human
spermatozoa.
