Antioxidant Therapies in the Treatment of Aminoglycoside‐Induced Ototoxicity: A Meta‐Analysis DOI
Patrick J. Gaffney, Kunal Shetty,

Sancak Yüksel

et al.

The Laryngoscope, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Objective A feared complication of aminoglycoside treatment is ototoxicity, which theorized to be attributed the production aminoglycoside‐induced reactive oxygen species. Previous studies using animal models have suggested that numerous therapies targeting reducing oxidative stress may prevent ototoxicity from aminoglycosides. However, few clinical been conducted on these antioxidants. This systematic review and meta‐analysis examines effectiveness antioxidant in ototoxicity. Data Sources PubMed, Embase, Web Science, ClinicalTrials.gov . Review Method literature search was August 2024. sought randomized controlled trials humans examining otologic outcomes following administration medications intended reduce stress. Results yielded 2037 results, seven met inclusion criteria. N‐acetylcysteine (NAC) investigated four studies, aspirin two vitamin E one study. Six examined benefit treatments for up 8 weeks after while study tested subjects' hearing 1 year. In pooled analysis, assessing NAC showed greatest reduction (RR 0.112, 95% CI, 0.032–0.395; p = 0.0007; I 2 18%), followed by 0.229, 0.080–0.650; 0.0057; 0%). One performed with did not find a compared placebo 0.841, 0.153–4.617; 0.8416). Conclusions Multiple shown are effective there lack high‐quality evidence. Additional should examine whether provide long‐term benefit, other promising antioxidants translate models. Level Evidence N/A Laryngoscope , 2024

Language: Английский

From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity DOI

Xiaxia Li,

Lina Ma

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 93, P. 102175 - 102175

Published: Dec. 23, 2023

Language: Английский

Citations

22
Therapeutic strategies targeting the NLRP3‑mediated inflammatory response and pyroptosis in cerebral ischemia/reperfusion injury (Review) DOI Creative Commons
Wanli Duan, Xuejie Wang, Yaping Ma

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 29(3)

Published: Jan. 22, 2024

Ischemic stroke poses a major threat to human health. Therefore, the molecular mechanisms of cerebral ischemia/reperfusion injury (CIRI) need be further clarified, and associated treatment approaches require exploration. The NOD‑like receptor thermal protein domain 3 (NLRP3) inflammasome serves an important role in causing CIRI, its activation exacerbates underlying injury. Activation NLRP3 triggers maturation production inflammatory molecules IL‑1β IL‑18, as well gasdermin‑D‑mediated pyroptosis CIRI damage. Thus, may viable target for CIRI. In present review, intense response induced by are discussed, therapeutic strategies that NLRP3‑mediated summarized. At present, certain drugs have already been studied, highlighting future perspectives.

Language: Английский

Citations

8
Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies DOI Creative Commons

Linghui Meng,

Shengyang Liu,

Jinfeng Luo

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 2, 2025

Oxidative stress, characterized by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defenses, is closely linked to the pathogenesis of various otorhinolaryngological disorders. Mitochondria, as primary site cellular energy production, play a crucial role in modulating oxidative stress. Mitochondrial dysfunction exacerbates ROS generation, leading damage inflammatory responses. In diseases, stress strongly associated with conditions such hearing loss, allergic rhinitis, chronic sinusitis, where tissue inflammation are key pathological features. Recent studies have highlighted potential therapies mitigate restore homeostasis, offering promising avenues for alleviating symptoms these diseases. However, despite encouraging results from early-stage research, clinical efficacy interventions remains be fully established. This review provides overview diseases evaluates therapeutic strategies.

Language: Английский

Citations

1
Sensorineural hearing loss and cognitive impairment: three hypotheses DOI Creative Commons
He Zhao, Yan Wang,

Limei Cui

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Feb. 28, 2024

Sensorineural hearing loss (SNHL) is a category of that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness auditory trauma, results cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers an abnormality the brain’s higher intellectual processes related learning, memory, thinking judgment can lead severe learning memory deficits. Studies have established strong correlation between SNHL CI, but it remains unclear how contributes CI. The purpose this article describe three hypotheses regarding relationship, mainstream load hypothesis, co-morbidity sensory deprivation as well latest research progress each hypothesis.

Language: Английский

Citations

6
NADPH Oxidase 3: Beyond the Inner Ear DOI Creative Commons
Marc Herb

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 219 - 219

Published: Feb. 8, 2024

Reactive oxygen species (ROS) were formerly known as mere byproducts of metabolism with damaging effects on cellular structures. The discovery and description NADPH oxidases (Nox) a whole enzyme family that only produce this harmful group molecules was surprising. After intensive research, seven Nox isoforms discovered, described extensively studied. Among them, the oxidase 3 is perhaps most underrated isoform, since it firstly discovered in inner ear. This stigma Nox3 "being expressed ear" also used by me several times. Therefore, question arose whether sentence still valid or even usable. To end, review solely focuses summarizes its discovery, structural components, activating regulating factors, expression cells, tissues organs, well beneficial detrimental Nox3-mediated ROS production body functions. Furthermore, involvement Nox3-derived diseases progression and, accordingly, potential target for disease treatment, will be discussed.

Language: Английский

Citations

3
NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration: potential therapeutic implications DOI Creative Commons

Xiaoli Wang,

Yun-Xia Gao,

Qiong-Zhen Yuan

et al.

International Journal of Ophthalmology, Journal Year: 2024, Volume and Issue: 17(8), P. 1531 - 1544

Published: July 24, 2024

Retinal degenerative diseases were a large group of characterized by the primary death retinal ganglion cells (RGCs). Recent studies had shown an interaction between autophagy and nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasomes, which may affect RGCs in diseases. The NLRP3 inflammasome was protein complex that, upon activation, produces caspase-1, mediating apoptosis promoting occurrence development Upregulated could inhibit while inhibited can promote leaded to accelerated emergence drusen lipofuscin deposition under neurosensory retina. activated further autophagy, thus forming vicious cycle that damage RGCs. This review discussed relationship its effects on age-related macular degeneration, providing new perspective direction for treatment

Language: Английский

Citations

3
Updated insights into the NLRP3 inflammasome in postoperative cognitive dysfunction: emerging mechanisms and treatments DOI Creative Commons
Tian Wang,

Guangwei Sun,

Bingdong Tao

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 30, 2024

Postoperative cognitive dysfunction (POCD) poses a significant threat to patients undergoing anesthesia and surgery, particularly elderly patients. It is characterized by diminished functions post such as impaired memory decreased concentration. The potential risk factors for POCD include age, surgical trauma, anesthetic type, overall health condition; however, the precise mechanisms underlying remain elusive. Recent studies suggest that neuroinflammation might be primary pathogenic factor. NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) inflammasomes are implicated in exacerbating promoting release of inflammatory proteins initiate pyroptosis, further influencing disease process. regulation NLRP3 inflammasome activity, including its activation degradation, tightly controlled through multiple pathways mechanisms. In addition, autophagy, protective mechanism, regulates control progression POCD. This review reviews recent findings on role pathogenesis discusses therapeutic strategies aimed at reducing sources, inhibiting cellular enhancing autophagy.

Language: Английский

Citations

3
Metformin-induced mitophagy suppresses auditory hair cell apoptosis via AMPK pathway DOI Creative Commons
Yifan Lai, Jiawei Qiu, Zheng Kuang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111214 - 111214

Published: Jan. 16, 2025

Language: Английский

Citations

0
Functional and Structural Changes in the Inner Ear and Cochlear Hair Cell Loss Induced by Hypergravity DOI Open Access

Jin Sil Choi,

Kyu‐Sung Kim, Hyun Ji Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 758 - 758

Published: Jan. 17, 2025

Gravitational changes have been shown to cause significant abnormalities in various body systems, including the cardiovascular, immune, vestibular, and musculoskeletal systems. While numerous studies examined response of vestibular system gravitational stimulation, research on functional peripheral inner ear remains limited. The comprises two closely related structures: vestibule cochlea. These components share similar structures neural functions, highlighting importance investigating auditory nerve cells alterations. To address this gap, we studied structural following exposure hypergravity stimuli. Our findings demonstrate brainstem responses (ABRs) ABR recordings were used analyze click thresholds, as well amplitude latency tone bursts. thresholds at all frequencies increased group exposed long term. Additionally, burst results revealed significantly reduced amplitudes high delayed latencies models. Notably, greater hair cell loss was observed middle basal turns cochlea, indicating that mid high-frequency regions are more vulnerable stimulation. Furthermore, damage cochlear surface evident subjects 4G stimulation for 4 weeks. suggest its activity can be functionally structurally affected by prolonged hypergravity.

Language: Английский

Citations

0
A OHCs‐Targeted Strategy for PEDF Delivery in Noise‐Induced Hearing Loss DOI Open Access
Zeqi Zhao,

Zhengzhong Han,

Youming Shao

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract Noise‐induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery the inner ear. This study applied a retro‐auricular round window membrane (RWM) method bypass BLB, enabling transport of macromolecular proteins into Pigment epithelium‐derived factor (PEDF), which has anti‐inflammatory neuroprotective properties, is conjugated prestin‐targeting peptide 2 (PrTP2) using N‐succinimidyl‐3‐maleimidopropionate (SMP) form PrTP2‐SMP/PEDF. compound specifically targeted Prestin accumulated around OHCs for sustained release, effectively reducing OHC SGN loss. Functional structural tests, including auditory brainstem response (ABR), confocal microscopy, scanning electron microscopy (SEM), revealed significant restoration cellular protection. Additionally, enzyme‐linked immunosorbent assay (ELISA), Annexin V propidium iodide (PI) staining immunoblotting show that noise may induce pyroptosis in cochlea by activating NOD‐like receptor protein 3 (NLRP3)‐apoptosis‐associated speck‐like containing CARD (ASC) – cysteinyl aspartate specific proteinase (Caspase‐1) pathway PrTP2‐SMP/PEDF alleviates inflammatory inhibiting pyroptosis. Toxicity analysis indicates no adverse effects, suggesting promising therapeutic prospective NIHL.

Language: Английский

Citations

0