Recent Developments in Methicillin-Resistant Staphylococcus aureus (MRSA) Treatment: A Review

Antibiotics, Journal Year: 2022, Volume and Issue: 11(5), P. 606 - 606

Published: April 29, 2022

Staphylococcus aureus (S. aureus) is a Gram-positive bacterium that may cause life-threatening diseases and some minor infections in living organisms. However, it shows notorious effects when becomes resistant to antibiotics. Strain variants of bacteria, viruses, fungi, parasites have become existing multiple antimicrobials are termed as superbugs. Methicillin semisynthetic antibiotic drug was used inhibit staphylococci pathogens. The S. methicillin known methicillin-resistant (MRSA), which became superbug due its defiant activity against the antibiotics medications most commonly treat major infections. Successful MRSA infection management involves rapid identification infected site, culture susceptibility tests, evidence-based treatment, appropriate preventive protocols. This review describes clinical pathogenesis, recent developments diagnosis, antimicrobial treatment choices for MRSA.

Language: Английский

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Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 413 - 413

Published: Jan. 31, 2023

The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads millions deaths all over the world. sharing genes between different types bacteria led emergence multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial by up 1000-fold increase MDR infections. absence novel potent antimicrobial compounds linked rise resistance. sparked international efforts develop new improved agents well innovative efficient techniques for administration targeting. There an evolution nanotechnology treatment prevention biofilm formation infection. development nanomaterial-based therapeutics, could overcome current pathways acquired drug resistance, hopeful strategy treating difficult-to-treat Additionally, nanoparticles’ distinct size physical characteristics enable them target biofilms treat pathogens. review highlights advances combat In addition, provides insight on mechanisms XDR infection, nanoparticles their antibacterial activity. Moreover, this considers difference free antibiotics nanoantibiotics, synergistic effect nanoantibiotics planktonic bacteria, intracellular biofilm. Finally, we will discuss strength limitations application against infection future perspectives.

Language: Английский

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Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 12, 2024

Antibiotics represent a frequently employed therapeutic modality for the management of bacterial infections across diverse domains, including human health, agriculture, livestock breeding, and fish farming. The efficacy antibiotics relies on four distinct mechanisms action, which are discussed in detail this review, along with accompanying diagrammatic illustrations. Despite their effectiveness, antibiotic resistance has emerged as significant challenge to treating infections. Bacteria have developed defense against antibiotics, rendering them ineffective. This review delves into specific that bacteria resist help Antibiotic can spread among through various routes, resulting previously susceptible becoming antibiotic-resistant. Multiple factors contribute worsening crisis resistance, misuse antibiotics. also emphasizes alternative solutions proposed mitigate exacerbation resistance.

Language: Английский

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Antimicrobial nanoparticles: current landscape and future challenges

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(3), P. 388 - 402

Published: Jan. 1, 2024

Antimicrobial resistance poses a serious threat to global health, necessitating the exploration of innovative solutions.

Language: Английский

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Antibiotic resistance and preventive strategies in foodborne pathogenic bacteria: a comprehensive review

Food Science and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.

Language: Английский

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Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 181, P. 114078 - 114078

Published: Dec. 8, 2021

Language: Английский

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State of the Art in the Antibacterial and Antiviral Applications of Carbon-Based Polymeric Nanocomposites

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10511 - 10511

Published: Sept. 29, 2021

The development of novel approaches to prevent bacterial infection is essential for enhancing everyday life. Carbon nanomaterials display exceptional optical, thermal, and mechanical properties combined with antibacterial ones, which make them suitable diverse fields, including biomedical food applications. Nonetheless, their practical applications as antimicrobial agents have not been fully explored yet, owing relatively poor dispersibility, expensiveness, scalability changes. To solve these issues, they can be integrated within polymeric matrices, also exhibit activity in some cases. This review describes the state art nanocomposites reinforced 0D fullerenes, 1D carbon nanotubes (CNTs), 2D graphene (G) its derivatives such oxide (GO) reduced (rGO). Given that a large number are available, only most illustrative examples described, mechanisms discussed. Finally, reviewed.

Language: Английский

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Antibacterial silver nanoparticles: effects on bacterial nucleic acids

Cellular Molecular and Biomedical Reports, Journal Year: 2023, Volume and Issue: 3(1), P. 35 - 40

Published: March 1, 2023

Various microorganisms are located on the human skin, mucous membrane and inside body. Many of these beneficial few even essential, however, some pathogens known to cause infection have ability attack damage host tissue. Treatment infectious bacterial disease by antibiotics is one major conventional strategies. Gram-positive Gram-negative bacteria developed resistance various mechanisms, including overexpression efflux pumps, preventing drug penetration into cells, genetic mutations, increased production competitive inhibitors antibiotics, or enzymes that inactivate hydrolyze antibiotics. Consequently, finding a new approach overcome hindrances vital for treatment severe infections. Nanomaterials can be effective therapeutic compounds, with unique properties compared bulk materials. Metal metal oxide nanoparticles, particularly silver demonstrated strong antibacterial activity against most (if not all) multidrug-resistant bacteria. Several mechanisms been proposed their interaction nucleic acids completely understood, so this review discusses recent advances in area.

Language: Английский

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Unleashing the power of polymeric nanoparticles — Creative triumph against antibiotic resistance: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134977 - 134977

Published: Aug. 24, 2024

Antibiotic resistance (ABR) poses a universal concern owing to the widespread use of antibiotics in various sectors. Nanotechnology emerges as promising solution combat ABR, offering targeted drug delivery, enhanced bioavailability, reduced toxicity, and stability. This comprehensive review explores concepts antibiotic resistance, its mechanisms, multifaceted approaches ABR. The provides an in-depth exploration polymeric nanoparticles advanced delivery systems, focusing on strategies for targeting microbial infections contributing fight against Nanoparticles revolutionize antimicrobial approaches, emphasizing passive active targeting. role molecules, including small peptides, proteins, carbohydrates, stimuli-responsive is being explored recent research works. complex comprehension mechanisms ABR strategic nanotechnology present avenue advancing tactics, ensuring treatment efficacy, minimizing toxic effects, mitigating development Polymeric nanoparticles, derived from natural or synthetic polymers, are crucial overcoming Natural polymers like chitosan alginate exhibit inherent antibacterial properties, while such polylactic acid (PLA), polyethylene glycol (PEG), polycaprolactone (PCL) can be engineered specific effects. study valuable source information researchers, healthcare professionals, policymakers engaged urgent quest overcome

Language: Английский

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