Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
A
general
protocol
for
the
synthesis
of
a
variety
functionalized
quinazolinones
has
been
developed
through
sequential
Pd-catalyzed
coupling/1,5-alkyloxy/thio/azole
shift/6π
electrocyclization
reaction
isocyanides
and
2-carbonylaryl
azides.
When
3-(2-isocyanoethyl)indoles
were
utilized,
an
unusual
competitive
between
[1,5]-shift
indole-spirocyclization
was
observed,
which
renders
modular
spiroindolenine-3,3'-pyrrolo[2,1-
Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 1, 2024
1,7-Hydride
transfer-involved
dearomatization
of
quinolines
toward
C3-spiro
hydroquinoline
derivatives
has
been
developed.
This
method
offers
a
protocol
to
achieve
the
electron-deficient
arenes
via
redox-neutral
hydride
transfer
process.
A
series
hydroquinolines
can
be
provided
in
moderate
excellent
yields
(up
98%)
with
good
diastereoselectivities.
Significant
advantages
such
as
high
step-
and
atom-economy,
well
mild
conditions,
make
it
an
appealing
alternative
quinolines.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(22), P. 16838 - 16849
Published: Nov. 6, 2024
Herein,
we
report
an
atom-economical,
one-pot,
four-component,
diastereoselective
double-annulation
reaction
to
construct
polyfused
pyrroloquinolines.
This
highlights
the
cyclization
of
in
situ
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(17), P. 3542 - 3563
Published: July 11, 2024
Abstract
C(
sp
3
)−H
functionalization
methods
have
been
widely
employed
in
many
organic
transformations
such
as
cyclization
reactions,
heterocycle
synthesis,
cross‐coupling
protocols,
and
photochemical
transformations.
Among
these
transformations,
reaction
through
offers
a
direct
route
to
convert
simple
linear
substrates
complex
products.
There
are
three
common
modes
of
utilizing
bonds
reactions
including
single,
double,
dual
functionalization.
As
the
most
challenging
mode,
refers
converting
two
separate
one
molecule
into
desired
C−Z
which
can
be
reactions.
Cyclization
via
classified
based
on
C−H
reactivities.
Therefore,
categorized
classes
types
activated‐activated,
activated‐unactivated,
unactivated‐unactivated
bonds.
Most
published
reports
for
involve
activated‐activated
However,
number
reported
papers
other
has
growing.
This
review
focuses
protocols
used
categorizes
New Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
47(27), P. 12536 - 12540
Published: Jan. 1, 2023
ortho
-Dialkylaminoarylidene
malonates
undergo
hydrogen
transfer
mediated
cyclization
in
the
absence
of
a
catalyst
under
irradiation.
The
process
suits
Green
chemistry
principles:
it
does
not
need
any
toxic
solvents
and
requires
only
light
to
proceed.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(36), P. 7300 - 7304
Published: Jan. 1, 2023
An
efficient,
scalable
cascade
[1,5]
hydride
transfer/cyclization
approach
for
the
construction
of
spirocyclic
pyrazolone-pyrrolo[4,3,2-
de
]quinoline
skeletons
through
C(sp
3
)–H
functionalization.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(33), P. 4899 - 4902
Published: Jan. 1, 2023
Unsaturated
N2-sulfonyl
amidines
are
transformed
into
valuable
N-heterocyclic
products
when
heated
with
BF2OTf.
Mechanism
studies
suggest
a
domino
1,7-H
shift,
activating
C-H
bond,
followed
by
electrocylisation
that
results
in
stereodefined
cyclic
amidines.
