Indian Journal of Pharmaceutical Education and Research,
Journal Year:
2025,
Volume and Issue:
59(1), P. 370 - 376
Published: Jan. 6, 2025
Background
Liver
cancer's
severity
has
prompted
interest
in
herbal
remedies
for
hepatotoxicity
and
the
disease.
Acacia
nilotica
(Vachellia
nilotica),
valued
its
traditional
medicinal
properties,
particularly
aerial
components,
is
being
investigated
hepatoprotective
anti-cancer
effects.
However,
research
on
A.
bark
extracts
their
mechanisms
of
action
limited.
Materials
Methods
The
study
aimed
to
determine
Total
Phenolic
Content
(TPC),
Flavonoid
(TFC),
antioxidant
properties
extract
using
biochemical
assays.
Additionally,
it
examined
protective
effects
normal
Cells
(LO2)
toxicity
against
liver
cancer
cells
(HepG2)
cell
culture
techniques.
Results
showed
significant
(EC50-16.34),
with
a
total
phenolic
content
159.98±9.91
mg
GAE/DW
flavonoid
16.93
QE/g
dry
weight.
It
exhibited
moderate
towards
HepG2
at
concentrations
>100
μg/mL
but
was
non-toxic
LO2
cells.
Moreover,
prevented
oxidative
damage
induced
by
H2O2.
Conclusion
These
findings
highlight
therapeutic
potential
treatment,
warranting
further
clinical
investigation.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15240 - 15240
Published: Oct. 16, 2023
This
review
focuses
on
DNA
damage
caused
by
a
variety
of
oxidizing,
alkylating,
and
nitrating
species,
it
may
play
an
important
role
in
the
pathophysiology
inflammation,
cancer,
degenerative
diseases.
Infection
chronic
inflammation
have
been
recognized
as
factors
carcinogenesis.
Under
inflammatory
conditions,
reactive
oxygen
species
(ROS)
nitrogen
(RNS)
are
generated
from
epithelial
cells,
result
formation
oxidative
nitrative
lesions,
such
8-oxo-7,8-dihydro-2'-deoxyguanosine
(8-oxodG)
8-nitroguanine.
Cellular
is
continuously
exposed
to
very
high
level
genotoxic
stress
physical,
chemical,
biological
agents,
with
estimated
10,000
modifications
occurring
every
hour
genetic
material
each
our
cells.
highlights
recent
developments
chemical
biology
toxicology
2'-deoxyribose
oxidation
products
DNA.
Soil
toxicity
is
a
major
environmental
issue
that
leads
to
numerous
harmful
effects
on
plants
and
human
beings.
Every
year
huge
amount
of
Pb
dumped
into
the
environment
either
from
natural
sources
or
anthropogenically.
Being
heavy
metal
it
highly
toxic
non-biodegradable
but
remains
in
for
long
time.
It
considered
neurotoxic
exerts
living
In
present
review
article,
investigators
have
emphasized
side
plants.
Further,
authors
focused
various
environment.
Investigators
responses
including
molecular,
biochemical,
morphological
levels
Pb.
Further
emphasis
was
given
effect
elevated
microbial
population
rhizospheres.
remediation
strategies
removal
soil
water
sources.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(11), P. 8715 - 8741
Published: Oct. 16, 2024
Certain
carotene
components,
such
as
lycopene
and
beta-carotene,
are
found
in
tomatoes,
carrots,
sweet
potatoes,
etc.
good
for
human
health.
It
gives
plants
their
distinctive
red
color.
A
class
of
lipid-soluble
natural
pigments
known
carotenoids
is
the
precursor
vitamin
vital
antioxidant
defense
against
peroxides
cells
tissues.
This
review
provides
an
overview
current
state
knowledge
research
on
sources,
structures,
physiochemical
properties,
absorption
metabolism,
functional
advantages,
prevention
many
diseases
associated
with
beta-carotene.
These
antioxidants
have
been
linked
to
a
lower
risk
cardiovascular
disease
cancer,
they
also
help
draw
pollinators
flowers.
Carrots
potatoes
rich
sources
which
strengthens
immune
system
improves
eye
The
vivid
color
reproductive
organs,
including
flowers
fruits,
caused
by
carotenoid,
secondary
metabolite
that
produced
plastids.
other
health
advantages
attributed
lycopene.
When
ingested
through
food
or
supplements,
beta-carotene
manage
prevent
number
diseases,
metabolic,
inflammatory,
cardiovascular,
hepatic,
ophthalmic,
skeletal,
infertility
disorders.
main
point
toxicity
uncommon,
these
generally
accepted
be
safe
at
different
doses.
Including
nutrients
your
diet
can
improve
general
provide
illness
prevention.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: April 3, 2024
Oxidative
stress
is
caused
by
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body’s
ability
to
counteract
their
harmful
effects,
playing
a
key
role
in
pathogenesis
brain
lung-related
diseases.
This
review
comprehensively
examines
intricate
mechanisms
which
oxidative
influences
cellular
molecular
pathways,
contributing
neurodegenerative,
cardiovascular,
respiratory
disorders.
Emphasizing
detrimental
effects
on
both
lung
health,
we
discuss
innovative
diagnostic
biomarkers,
such
as
8-hydroxy-2′-deoxyguanosine
(8-OHdG),
potential
antioxidant
therapies.
For
these
topics,
provide
insights
into
future
research
directions
field
treatment,
including
development
personalized
treatment
approaches,
discovery
validation
novel
new
drug
delivery
systems.
not
only
provides
perspective
understanding
diseases
but
also
offers
for
clinical
treatments.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(1), P. 68 - 68
Published: Jan. 19, 2024
Acute
Lung
Injury
(ALI)
is
a
life-threatening
syndrome
that
has
been
identified
as
potential
complication
of
COVID-19.
There
critical
need
to
shed
light
on
the
underlying
mechanistic
pathways
and
explore
novel
therapeutic
strategies.
This
study
aimed
examine
effects
Citrus
clementine
essential
oil
(CCEO)
in
treating
potassium
dichromate
(PDC)-induced
ALI.
The
chemical
profile
CCEO
was
created
through
GC–MS
analysis.
An
vivo
rats
conducted
evaluate
effect
administrated
via
two
different
delivery
systems
(oral/inhalation)
mitigating
acute
lung
injury
induced
by
intranasal
instillation
PDC.
Eight
volatile
compounds
were
identified,
with
monoterpene
hydrocarbons
accounting
for
97.03%
constituents,
including
88.84%
D-limonene.
at
doses
100
200
mg/kg
bw
exhibited
antioxidant
anti-inflammatory
properties.
These
significant
properties
revealed
reduction
malondialdehyde
(MDA)
restoration
reduced
glutathione
(GSH).
In
addition,
inflammation
observed
decreasing
levels
cytokines
tumor
necrosis
factor-α
growth
factor-β
(TNF-α
TGF-β),
along
an
increase
phosphatidylinositide-3-kinase
(PI3K)
Akt
overexpression
tissue
homogenate,
both
oral
inhalation
routes,
compared
PDC-induced
group.
results
supported
histopathological
studies
immunohistochemical
assessment
TGF-β
tissues.
findings
plays
integral
role
relieving
ALI
PDC
suggests
it
promising
remedy.
