Risk Factors for the Development of Psoriasis

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(18), P. 4347 - 4347

Published: Sept. 5, 2019

Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms involve complex interaction between the innate and adaptive immune system. T cells interact with dendritic cells, macrophages, keratinocytes, which can be mediated by their secreted cytokines. In past decade, biologics targeting tumor necrosis factor-α, interleukin (IL)-23, IL-17 have been developed approved for treatment of psoriasis. These dramatically changed management contrast, various triggering factors elicit disease in genetically predisposed individuals. Recent studies suggest that exacerbation psoriasis lead to systemic inflammation cardiovascular comorbidity. addition, may associated other auto-inflammatory auto-immune diseases. this review, we summarize risk factors, divided into two groups (namely, extrinsic intrinsic factors), responsible onset order facilitate its prevention.

Language: Английский

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Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: July 22, 2022

The human intestine hosts diverse microbial communities that play a significant role in maintaining gut-skin homeostasis. When the relationship between gut microbiome and immune system is impaired, subsequent effects can be triggered on skin, potentially promoting development of skin diseases. mechanisms through which affects health are still unclear. Enhancing our understanding connection needed to find novel ways treat disorders. In this review, we systematically evaluate current data regarding ecology healthy gut, diet, pre- probiotics, antibiotics, their health. We discuss potential axis link skin-associated diseases, such as psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa. This review will increase impacts conditions aid finding new medications for

Language: Английский

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Challenges in exploring and manipulating the human skin microbiome

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: May 30, 2021

Abstract The skin is the exterior interface of human body with environment. Despite its harsh physical landscape, colonized by diverse commensal microbes. In this review, we discuss recent insights into microbial populations, including their composition and role in health disease modulation intrinsic extrinsic factors, a focus on pathobiological basis aging. We also describe most tools for investigating microbiota microbe-skin relationships perspectives regarding challenges microbiome manipulation.

Language: Английский

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Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(8), P. 3998 - 3998

Published: April 13, 2021

Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A decrease microbiome alpha-diversity (abundance of different bacterial taxa measured one sample) as well beta-diversity (microbial diversity samples) was noted psoriasis skin. It has been proven that the representation Cutibacterium, Burkholderia spp., Lactobacilli is decreased Corynebacterium kroppenstedii, simulans, Neisseria Finegoldia spp. increased comparison to healthy Alterations are similar those observed inflammatory bowel disease. In two diseases, F. prausnitzii, Bifidobacterium Lactobacillus Parabacteroides Coprobacillus were underrepresented, while abundance Salmonella sp., Campylobacter Helicobacter Escherichia coli, Alcaligenes Mycobacterium sp. increased. Several research provided evidence for influence treatments on a positive orally administered probiotics course this dermatosis. Further needed determine development diseases. The changes under treatment can serve potential biomarker response therapy.

Language: Английский

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The Human Skin Microbiome in Selected Cutaneous Diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: March 7, 2022

The human skin harbors a wide variety of microbes that, together with their genetic information and host interactions, form the microbiome. role microbiome in development various diseases has lately gained interest. According to several studies, changes cutaneous microbiota are involved pathophysiology dermatoses. A better delineation its interactions innate adaptive immune systems could lead understanding these diseases, as well opportunity achieve new therapeutic modalities. present review centers on most recent knowledge participation pathogenesis disorders: atopic seborrheic dermatitis, alopecia areata, psoriasis acne.

Language: Английский

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Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1037 - 1037

Published: April 30, 2022

Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to bidirectional relationship between and health. This is regulated through several mechanisms inflammatory mediators immune system. Dysregulation microbiota been seen numerous conditions atopic dermatitis, rosacea, Understanding how are involved regulating health may lead novel therapies for these modulation, particularly In this review, we will compare psoriasis patients healthy control, explain concept effects dysbiosis on physiology. We also review current evidence using probiotics

Language: Английский

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Triggers for the onset and recurrence of psoriasis: a review and update

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 12, 2024

Abstract Psoriasis is an immune-mediated inflammatory skin disease, involving a complex interplay between genetic and environmental factors. Previous studies have demonstrated that factors play major role in the pathogenesis of psoriasis. However, non-genetic are also necessary to trigger onset recurrence psoriasis genetically predisposed individuals, which include infections, microbiota dysbiosis gut, dysregulated lipid metabolism, sex hormones, mental illness. can be induced by other triggers, such as trauma, unhealthy lifestyles, medications. Understanding how these triggers provides insights into pathogenesis, well better clinical administration. In this review, we summarize for update current evidence on underlying mechanism elicit disease.

Language: Английский

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Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 23, 2021

Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that parameters of psoriasis mediate development MetS. We reviewed potential association between and MetS, endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production reactive oxygen species, alterations adipocytokine levels gut microbiota dysbiosis. Here, we highlight important research questions regarding offer insights into MetS treatment.

Language: Английский

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Psoriasis and Gut Microbiome—Current State of Art

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(9), P. 4529 - 4529

Published: April 26, 2021

Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide. Several studies concerning the gut microbiota composition and its role in pathogenesis recently demonstrated significant alterations among psoriatic patients. Certain parameters such as Firmicutes/Bacteroidetes ratio or Microbiome Index were developed order to distinguish between healthy individuals. The “leaky syndrome” bacterial translocation considered by some authors triggering factor for onset of disease, it promotes chronic systemic inflammation. also found resemble those bowel diseases, obesity certain cardiovascular diseases. Microbiota dysbiosis, depletion SCFAs production, increased amount produced TMAO, dysregulation pathways affecting balance lymphocytes populations seem be most findings physiology may serve potential response-to-treatment biomarker cases biological treatment. Oral probiotics administration well fecal microbial transplantation reported bringing health benefits However, issue composition, healing needs further investigation. Here we reviewed literature on current state relationship psoriasis microbiome.

Language: Английский

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Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: July 29, 2020

Abstract Psoriasis is an immune-mediated skin disorder. Imbalance of gut microbial populations has been implicated in many diseases. We aimed to investigate whether there were differences microbiota psoriasis patients vs non-psoriasis controls and between severity groups. 55 27 included. V3–V4 regions the 16S rRNA gene fecal samples analyzed using Illumina MiSeq. Bioinformatic analysis was performed. found changes microbiome composition depending on their status as determined by weighted unifrac (p < 0.05), particular increase Firmicutes depletion Bacteroidetes patients. Additionally, Faecalibacterium Blautia genus higher while Bacteroides Paraprevotella 0.05, LDA score > 2). Moderate-to-severe had lower biodiversity than mild psoriatic = 0.049). No for beta-diversity found. developed a Psoriasis-Microbiota Index (PMI), which discriminated among with sensitivity: 0.78 specificity: 0.79. Furthermore, we performed meta-analysis published data validate this index. demonstrated dysbiosis patients, suggesting role pathophysiology. PMI potential discriminate across different populations, could be used biomarker clinical practice.

Language: Английский

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