Phylogenomics, divergence times and notes of orders in Basidiomycota

Fungal Diversity, Journal Year: 2024, Volume and Issue: 126(1), P. 127 - 406

Published: July 9, 2024

Language: Английский

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Skin microbiome of atopic dermatitis

Allergology International, Journal Year: 2021, Volume and Issue: 71(1), P. 31 - 39

Published: Nov. 24, 2021

The skin microbiome is a key component of pathogenesis in atopic dermatitis (AD). AD patients characterized by microbial dysbiosis, with reduction diversity and overrepresentation pathogenic Staphylococcus aureus (S. aureus). Recent exciting studies have elucidated an importance establishing appropriate immune response to microbes early life uncovered the new mechanisms community dynamics modulating our microbiome. Several are associated pathogenesis, proposed effects from S. Malassezia. complex relationships between within consortia includes various species, such as Staphylococcal, Roseomonas Cutibacterium strains, that can inhibit potential probiotics for skin. Numerous now also reported modulate host via communication keratinocytes, specialized cells adipocytes improve health barrier function. This increased understanding microbiota bioactives has led biotherapeutic approaches target surface microenvironment treatment.

Language: Английский

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Roles of Infection in Psoriasis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(13), P. 6955 - 6955

Published: June 23, 2022

Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, immune dysfunction all contribute to the pathogenesis of psoriasis host-microbe interaction governing progression this disease. Emerging evidence has indicated that infection an trigger for plays multiple roles in its maintenance as evidenced by frequent association between guttate onset acute streptococcal infection. Different infectious factors act on cells produce inflammatory cytokines can induce or aggravate psoriasis. In addition bacterial infections, viral fungal infections have also been shown be strongly associated exacerbation Intervention skin microbiota treat become hot research topic. review, we summarize effects different (bacteria, viruses, fungi) psoriasis, thereby providing insights into manipulation pathogens allow identification improved therapeutic options treatment condition.

Language: Английский

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Malassezia: A Commensal, Pathogen, and Mutualist of Human and Animal Skin

Annual Review of Microbiology, Journal Year: 2022, Volume and Issue: 76(1), P. 757 - 782

Published: Sept. 8, 2022

Identified in the late nineteenth century as a single species residing on human skin, Malassezia is now recognized diverse genus comprising 18 inhabiting not only skin but gut, hospital environments, and even deep-sea sponges. All cultivated are lipid dependent, having lost genes for synthesis carbohydrate metabolism. The surging interest results from development of tools to improve sampling, culture, identification, genetic engineering, which has led findings implicating it numerous diseases, Crohn disease, pancreatic cancer. However, become clear that plays multifaceted role health, with mutualistic activity atopic dermatitis preventive effect against other infections due its potential compete pathogens such Candida auris. Improved understanding complex microbe-microbe host-microbe interactions will be required define Malassezia’s animal health disease so design targeted interventions.

Language: Английский

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One population, multiple lifestyles: Commensalism and pathogenesis in the human mycobiome

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(4), P. 539 - 553

Published: April 1, 2023

Language: Английский

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Modulating the skin mycobiome-bacteriome and treating seborrheic dermatitis with a probiotic-enriched oily suspension

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 1, 2024

Abstract Seborrheic dermatitis (SD) affects 2–5% of the global population, with imbalances in skin microbiome implicated its development. This study assessed impact an oily suspension containing Lactobacillus crispatus P17631 and Lacticaseibacillus paracasei I1688 (termed EUTOPLAC) on SD symptoms mycobiome-bacteriome modulation. 25 patients were treated EUTOPLAC for a week. Symptom severity changes measured at start treatment (T0), after seven days (T8), three weeks post-treatment (T28). Results indicated symptom improvement post-EUTOPLAC, notable reductions Malassezia genus. Concurrently, bacterial shifts observed, including decrease Staphylococcus increase . Network analysis highlighted post-EUTOPLAC instability fungal interactions, increased negative correlations between genera. The suggests EUTOPLAC's potential as targeted treatment, reducing modulating composition.

Language: Английский

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Review: A Contemporary, Multifaced Insight into Psoriasis Pathogenesis

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 535 - 535

Published: May 16, 2024

Psoriasis is a chronic recurrent inflammatory autoimmune pathology with significant genetic component and several interferences of immunological cells their cytokines. The complex orchestration psoriasis pathogenesis related to the synergic effect immune cells, polygenic alterations, autoantigens, other external factors. major act IL-23/IL-17 axis, strongly influencing pattern established during disease activity, visible as continuous perpetuation pro-inflammatory response keratinocyte activation proliferation, leading development psoriatic lesions. Genome-wide association studies (GWASs) offer better view pathogenic pathways, approximately one-third psoriasis’s impact on associated MHC region, loci located chromosome 6. most eloquent factor psoriasis, PSORS1, was identified in I site. Among factors involved its etiology, dysbiosis, due or stimulus, induces burst consequences; both cutaneous gut microbiome get process. Cutting-edge research comprehensive insights into pathogenesis, fostering novel genetic, epigenetic, factors, have generated spectacular improvement over past decades, securing path toward specific targeted immunotherapeutic approach delayed progression arthritis. This review aimed insight various domains that underline how they influence evolution. mechanism multifaceted involves an interplay cellular humoral immunity, which affects susceptible microbiota background. An in-depth understanding role forms basis for developing individualized therapeutic targets can improve management.

Language: Английский

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Exploring the skin microbiome in atopic dermatitis pathogenesis and disease modification

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 154(1), P. 31 - 41

Published: May 16, 2024

Language: Английский

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Diverse Colonisation and Disease Associations of the Human Commensal Malassezia: Our Body's Secret Tenant

Mycoses, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 1, 2025

ABSTRACT A niche in the context of microorganisms defines specific ecological role or habitat inhabited by microbial species within an ecosystem. For human commensal Malassezia , skin surface is considered its primary niche, where it adapts to environment utilising lipids as main carbon and energy source. However pathogenic characteristics include production allergens, immune modulation excessive lipid utilisation, which result several diseases such pityriasis versicolor, seborrheic dermatitis, folliculitis atopic dermatitis. Recent studies have revealed colonisation internal organs, including lungs, gut, genitourinary tract, eyes, ears breast milk. In these associated with linked respiratory conditions, neurological disorders, gastrointestinal genital infections. The system plays a critical shaping prevalence, factors like, suppressive drugs underlying health conditions influencing susceptibility. Accurate diagnosis ‐related disorders challenging due unique growth requirements, but molecular fingerprinting assays sequencing methods, particularly ITS sequencing, offer precise identification. Treatment involves antifungal drugs, corticosteroids phytocompounds, yet recurrent infections highlight need for more targeted therapeutic strategies addressing 's characteristics. Understanding complex interactions between host organs crucial diagnosis, treatment prevention exploring potentially beneficial roles disease. This review highlights current findings on intricate diverse ecosystem body, underscoring complexity associations emphasising their multifaceted

Language: Английский

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Life stage impact on the human skin ecosystem: lipids and the microbial community

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 13, 2025

Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between oxylipins and on the superficial of pre-pubescent children (N = 36) adults 100), including pre- 25) post-menopausal females 25). Lipidomics metagenomics revealed that Malassezia restricta positively correlated with oxylipin 9,10-DiHOME adult negatively its precursor, 9,10-EpOME, skin. Co-culturing keratinocytes demonstrated a link pro-inflammatory cytokines IL-1β IL-6 production. We also observed strong other microbial taxa, highlighting life stage differences in sebum production community composition. Our findings imply complex host-microbe communication system mediated metabolism occurring human skin, warranting further research role health disease paving way towards novel therapeutic targets treatments.

Language: Английский

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