The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(6), P. 100663 - 100663

Published: June 1, 2022

Language: Английский

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Covid-19 vaccine hesitancy: Text mining, sentiment analysis and machine learning on COVID-19 vaccination Twitter dataset

Expert Systems with Applications, Journal Year: 2022, Volume and Issue: 212, P. 118715 - 118715

Published: Sept. 5, 2022

In 2019 there was an outbreak of coronavirus pandemic also known as COVID-19. Many scientists believe that the originated from Wuhan, China, before spreading to other parts globe. To reduce spread disease, decision makers encouraged measures such hand washing, face masking, and social distancing. early 2021, some countries including United States began administering COVID-19 vaccines. Vaccination brought a relief public; it generated lot debates anti-vaccine pro-vaccine groups. The controversy debate surrounding vaccine influenced several people in either accept or reject vaccination. Because data limitations, media data, collected through live streaming public tweets using Application Programming Interface (API) search, is considered viable reliable resource study opinion on Covid-19 hesitancy. Thus, this examines 3 sentiment computation methods (Azure Machine Learning, VADER, TextBlob) analyze Five learning algorithms (Random Forest, Logistics Regression, Decision Tree, LinearSVC, Naïve Bayes) with different combination three vectorization (Doc2Vec, CountVectorizer, TF-IDF) were deployed. Vocabulary normalization threefold; potter stemming, lemmatization, stemming lemmatization. For each vocabulary strategy, we designed, developed, evaluated 42 models. shows hesitancy slowly decreases over time; suggesting gradually feels warm optimistic about Moreover, combining lemmatization increased model performances. Finally, result our experiment TextBlob + TF-IDF LinearSVC has best performance classifying into positive, neutral, negative accuracy, precision, recall F1 score 0.96752, 0.96921, 0.92807 0.94702 respectively. It means achieved when score, classification model. We found out two vectorizations (CountVectorizer accuracy.

Language: Английский

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Community resilience to pandemics: An assessment framework developed based on the review of COVID-19 literature

International Journal of Disaster Risk Reduction, Journal Year: 2022, Volume and Issue: 80, P. 103248 - 103248

Published: Aug. 14, 2022

Language: Английский

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COVID-19 Pandemic and Vaccines Update on Challenges and Resolutions

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Sept. 10, 2021

The coronavirus disease (COVID-19) is caused by a positive-stranded RNA virus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), belonging to the Coronaviridae family. This originated in Wuhan City, China, and became cause of multiwave pandemic that has killed 3.46 million people worldwide as May 22, 2021. havoc intensified with emergence SARS-CoV-2 variants (B.1.1.7; Alpha, B.1.351; Beta, P.1; Gamma, B.1.617; Delta, B.1.617.2; Delta-plus, B.1.525; Eta, B.1.429; Epsilon etc.) due mutations generated during replication. More may emerge additional waves. most promising approach for combating viruses their emerging lies prophylactic vaccines. Several vaccine candidates are being developed using various platforms, including nucleic acids, live attenuated virus, inactivated viral vectors, protein-based subunit In this unprecedented time, 12 vaccines against have been phased following WHO approval, 184 preclinical stage, 100 clinical development process. Many them directed elicit neutralizing antibodies spike protein (S) inhibit entry through ACE-2 receptor host cells. Inactivated vaccines, contrary, provide wide range antigens immune activation. Being an intracellular pathogen, cytotoxic CD8+ T Cell (CTL) response remains crucial all viruses, SARS-CoV-2, needs be explored detail. review, we try describe compare approved currently distributed either after phase III trials or emergency use. We discuss responses induced candidate formulations; benefits, potential limitations, effectiveness variants; future challenges, such antibody-dependent enhancement (ADE); safety issues possible resolutions. Most current showing compromised efficacy new variants. Multiple antigen-based (multivariant vaccines) should on different platforms tackle Alternatively, recombinant BCG, containing multiple antigens, long-term protection. Irrespective efficacy, efficient providing protection from severity. must insist compliance age groups work hesitancy globally achieve herd immunity and, eventually, curb pandemic.

Language: Английский

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Patients’ Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(10), P. 5086 - 5086

Published: May 11, 2021

The use of traditional medicinal plants in Saudi Arabia stems mainly from consumers’ belief prophetic medicine. This study was conducted to explore changes patients’ dietary or herbal supplements among individuals infected with COVID-19 before and during infection the association between hospitalization. A cross-sectional, questionnaire-based enrolling symptomatic patients who had recently recovered COVID-19. Data were collected through phone interviews, McNemar’s test used investigate consumption infection. Multivariable logistic regression total 738 included this study, whom 32.1% required About 57% participants male a mean age 36.5 (±11.9) years. lemon/orange, honey, ginger, vitamin C, black seed significantly increased their In contrast, using anise, peppermint, coffee peel more likely stop them addition, lemon/orange (p < 0.0001), honey = 0.0002), ginger 0.0053), C 0.0006), peppermint 0.0027), costus 0.0095), turmeric 0.0012) higher nonhospitalized than hospitalized ones. However, multivariable regression, only (OR 0.51; 95% CI 0.33–0.79), 0.53; 0.31–0.90), 0.54; 0.33–0.88) associated lower odds reveals that changed response infection, having likelihood these supplements. Because some hospitalization, bioactive components should be further investigated as feasible options for treatment.

Language: Английский

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Evaluation of electropolymerized molecularly imprinted polymers (E-MIPs) on disposable electrodes for detection of SARS-CoV-2 in saliva

Analytica Chimica Acta, Journal Year: 2022, Volume and Issue: 1206, P. 339777 - 339777

Published: April 1, 2022

We investigate electropolymerized molecularly imprinted polymers (E-MIPs) for the selective recognition of SARS-CoV-2 whole virus. E-MIPs with pseudoparticles (pps) were electrochemically deposited onto screen printed electrodes by reductive electropolymerization, using water-soluble N-hydroxmethylacrylamide (NHMA) as functional monomer and crosslinked N,N'-methylenebisacrylamide (MBAm). showed selectivity template pps, an imprinting factor 3:1, specificity (significance = 0.06) when cross-reacted other respiratory viruses. detected presence pps in <10 min a limit detection 4.9 log

Language: Английский

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SARS-CoV-2: A Master of Immune Evasion

Biomedicines, Journal Year: 2022, Volume and Issue: 10(6), P. 1339 - 1339

Published: June 7, 2022

Viruses and their hosts have coevolved for a long time. This coevolution places both the pathogen human immune system under selective pressure; on one hand, has evolved to combat viruses virally infected cells, while developed sophisticated mechanisms escape recognition destruction by system. SARS-CoV-2, that is causing current COVID-19 pandemic, shown remarkable ability antibody neutralization, putting vaccine efficacy at risk. One of virus’s evasion strategies mitochondrial sabotage: reactive oxygen species (ROS) production, physiology impaired, interferon antiviral response suppressed. Seminal studies identified an intra-cytoplasmatic pathway viral infection, which occurs through construction tunneling nanotubes (TNTs), hence enhancing infection avoiding surveillance. Another method evading monitoring disruption antigen presentation. In this scenario, SARS-CoV-2 reduces MHC-I molecule expression: SARS-CoV-2’s open reading frames (ORF 6 ORF 8) produce proteins specifically downregulate molecules. All these are also exploited other elude detection should be studied in depth improve effectiveness future treatments. Compared Wuhan strain or Delta variant, Omicron mutations impaired its generate syncytia, thus reducing pathogenicity. Conversely, allowed it neutralization preventing cellular recognition, making most contagious evasive variant date.

Language: Английский

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Pre- and Post-Pandemic (COVID-19) Mental Health of International Students: Data from a Longitudinal Study

Psychology Research and Behavior Management, Journal Year: 2023, Volume and Issue: Volume 16, P. 431 - 446

Published: Feb. 1, 2023

Purpose: International students are highly vulnerable to the risk of mental health worsening before and during pandemic (COVID-19). This study investigated international students' pre- post-pandemic Methods: It is a longitudinal study, data were collected online, pre-pandemic (N = 470) 420). Using random sampling technique, self-administered questionnaire was used measure health, including depression anxiety. Results: Findings show that good in pre-pandemic. Meanwhile, found be more depressed anxious pandemic. also phase, young mainly females' worsened. Conclusion: concluded problems alarming, so university should provide psychological services for student's health. Post-pandemic leaving long-lasting effects will require further investigation. Keywords: Covid-19, anxiety, depression, students,

Language: Английский

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Impact of the pandemic on the mental health of women workers at a health center in Vilcún (Chile): an exploratory study

Región Científica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The COVID-19 pandemic significantly impacted the physical, psychological, economic, and sociocultural levels, resulting in integration into new non-face-to-face work (teleworking) educational social restrictions, among others. objective of research was to understand impact on mental health women working at a primary care center Vilcún (Chile). From qualitative perspective, an exploratory, cross-sectional, non-experimental design adopted. An intentional non-probabilistic sampling used, it made up 10 workers sector. Data collection carried out through semi-structured interviews, whose stories were systematized content analysis. presence stressful symptoms, such as emotional exhaustion frustration participants, identified. Likewise, some perceived state greater vulnerability risk contagion that could affect their family members. In addition, observed played leading roles tasks associated with home child-rearing. obstacles challenges face healthcare personnel during are discussed, well transformation modality.

Language: Английский

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Virtual Reality (VR) Technology for Treatment of Mental Health Problems during COVID-19: A Systematic Review

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(9), P. 5389 - 5389

Published: April 28, 2022

There was a surge in psychological distress and emotional burnout during the COVID-19 pandemic. Virtual reality (VR) is helpful as intervention whilst maintaining physical or social distancing. The present systematic review assessed role of VR tool for mental health problems We conducted that followed Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) guidelines. This study used search-related terms: (Virtual OR simulated-3D-environment VR) AND (covid! corona!) (mental* psychologic* well* health*) (intervention) on six databases, i.e., MEDLINE, PsycINFO, Ovid Medline, EMBASE, ACM digital library, Cochrane Central Register Controlled Trials (CENTRAL) from inception date until 23 June 2021. finally included four studies out 379 references imported screening. These reveal beneficial individuals with problems. Immersed telepresence, interacting 3-D format compared to 2-D layout, having sense enjoyment engagement, activating an affective-motivational state, "escaping" virtual real world are pivotal faucets intervention.

Language: Английский

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