Journal of Biomedical Research & Environmental Sciences,
Journal Year:
2022,
Volume and Issue:
3(10), P. 1208 - 1223
Published: Oct. 1, 2022
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
affects
other
systems,
including
the
digestive,
circulatory,
urogenital,
and
even
central
nervous
as
its
receptor
Angiotensin-Converting
Enzyme-2
(ACE-2)
is
expressed
in
several
organs,
such
lungs,
intestine,
heart,
esophagus,
kidneys,
bladder,
testes,
liver
brain.
Different
mechanisms,
particular,
massive
virus
replication,
extensive
apoptosis
necrosis
of
lung-related
epithelial
endothelial
cells,
vascular
leakage,
hyperinflammatory
responses,
overproduction
proinflammatory
mediators,
cytokine
storm,
oxidative
stress,
downregulation
ACE2
impairment
renin-angiotensin
system
contribute
to
pathogenesis
COVID-19.
Currently,
COVID-19
a
global
pandemic
with
no
specific
antiviral
treatment.
The
favorable
abilities
ginger
were
indicated
patients
suffering
from
osteoarthritis,
neurodegenerative
disorders,
rheumatoid
arthritis,
type
diabetes,
respiratory
distress,
diseases,
primary
dysmenorrhea.
Ginger
or
compounds
exhibited
strong
anti-inflammatory
antioxidant
influences
numerous
animal
models.
This
review
provides
evidence
regarding
potential
effects
against
SARS-CoV-2
infection
highlights
antiviral,
anti-inflammatory,
antioxidant,
immunomodulatory
impacts
an
attempt
consider
this
plant
alternative
therapeutic
agent
for
treatment
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3320 - 3320
Published: July 26, 2023
Over
the
last
20
years,
use
of
dietary
supplements
(DS)
has
continued
to
grow
in
many
countries.
Due
public
health
crisis
brought
on
by
COVID-19
pandemic
and
amidst
fears
regarding
vaccines
their
low
supply
regions
world,
there
been
a
marked
interest
DS
as
alternative
means
protecting
against
treating
this
emerging
disease,
well
boosting
immune
system
minimizing
risk
inflammation.
Despite
lack
evidence
suggest
efficacy,
surge
sales
reported
parts
world.
Questions
have
also
raised
about
effects
associated
with
due
increased
during
crisis.
Numerous
scientific
studies
demonstrated
beneficial
properties
some
adverse
even
toxic
effects.
In
addition,
given
current
global
issue,
review
is
needed
establish
status
before
The
aim
summarize
impact
incidence
pandemic,
regulation
market
trends.
First,
we
provide
an
overview
DS,
including
comprehensive
legislative
regulatory
aspects
USA,
China,
EU,
Algeria.
Second,
describe
prevalence
most
commonly
consumed
efficacy
prophylactic
modality
era
COVID-19.
Additionally,
examine
structure
size
countries
that
predominantly
produce
import
them,
its
trend,
growth.
Finally,
review,
discuss
profile
users.
Metabolism Open,
Journal Year:
2021,
Volume and Issue:
12, P. 100141 - 100141
Published: Oct. 19, 2021
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
the
cause
pandemic
of
disease
2019
(COVID-19).
For
many
thousands
years,
herbal
products
and
dietary
plants
have
been
prescribed
for
various
diseases
by
traditional
healers.
Thus,
aim
this
review
to
present
main
products,
their
source,
characteristics,
potential
antiviral
actions
concerning
COVID-19.
Publications
on
related
effects
were
searched
from
different
databases,
such
as
Web
Science,
Google
Scholar,
Medline,
Scopus,
PubMed,
until
August
2021,
using
English
key
terms.
According
studies,
there
are
so
important
medicinal
with
activity,
which
can
be
used
viral
infections
or
supportive
treatment.
lack
information
safety
profile
amount
dose
some
limitations
plants.
medicine
interfere
COVID-19
pathogenesis
inhibiting
SARS-CoV-2
replication
entry
host
cells.
Some
plant
species
Journal of Traditional Chinese Medical Sciences,
Journal Year:
2021,
Volume and Issue:
8(4), P. 267 - 279
Published: Oct. 1, 2021
In
addition
to
the
respiratory
system,
severe
acute
syndrome
coronavirus
2
(SARS-CoV-2)
strikes
other
systems,
including
digestive,
circulatory,
urogenital,
and
even
central
nervous
as
its
receptor
angiotensin-converting
enzyme
(ACE2)
is
expressed
in
various
organs,
such
lungs,
intestine,
heart,
esophagus,
kidneys,
bladder,
testis,
liver,
brain.
Different
mechanisms,
particular,
massive
virus
replication,
extensive
apoptosis
necrosis
of
lung-related
epithelial
endothelial
cells,
vascular
leakage,
hyper-inflammatory
responses,
overproduction
pro-inflammatory
mediators,
cytokine
storm,
oxidative
stress,
downregulation
ACE2,
impairment
renin-angiotensin
system
contribute
COVID-19
pathogenesis.
Currently,
a
global
pandemic
with
no
specific
anti-viral
treatment.
The
favorable
capabilities
ginger
were
indicated
patients
suffering
from
osteoarthritis,
neurodegenerative
disorders,
rheumatoid
arthritis,
type
diabetes,
distress,
liver
diseases
primary
dysmenorrheal.
Ginger
or
compounds
exhibited
strong
anti-inflammatory
anti-oxidative
influences
numerous
animal
models.
This
review
provides
evidence
regarding
potential
effects
against
SARS-CoV-2
infection
highlights
antiviral,
anti-inflammatory,
antioxidative,
immunomodulatory
impacts
an
attempt
consider
this
plant
alternative
therapeutic
agent
for
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(2), P. 1071 - 1088
Published: Jan. 2, 2024
Abstract
A
sudden
outbreak
of
the
COVID‐19
pandemic
was
a
big
blow
to
world
community
on
every
level.
Created
by
novel
coronavirus,
SARS‐CoV‐2,
which
previously
unknown
human
immune
system.
The
expert
opinion
almost
immediately
united
fact
that
most
effective
way
fighting
would
be
building
immunity
artificially
via
mass
immunization
program.
However,
it
took
about
year
for
approval
first
vaccine
against
COVID‐19.
In
meantime,
part
general
population
started
adapting
nutritious
diet
plans
and
dietary
supplements
boost
natural
as
potential
prophylactic
strategy
SARS‐CoV‐2
infection.
Whether
they
originate
from
mainstream
medicine,
such
synthetic
supplements,
or
traditional
herbal
remedies
in
form
single
poly‐herbs,
these
may
comprise
various
components
exhibit
immunomodulatory,
anti‐inflammatory,
antioxidant,
antimicrobial
characteristics.
There
is
substantial
body
predictions
opinions
suggesting
enhancing
one's
with
containing
additional
nutrients
bioactive
compounds
like
vitamins,
minerals,
amino
acids,
fatty
phytochemicals,
probiotics
can
enhance
system's
ability
develop
resistance
COVID‐19,
although
none
them
have
any
conclusive
evidence
nor
officially
recommended
World
Health
Organization
(WHO).
current
review
critically
acclaims
gap
between
public
perception‐based
preference
real
evidence‐based
study
weigh
actual
benefit
relation
prevention
management.
Frontiers in Medicine,
Journal Year:
2022,
Volume and Issue:
9
Published: May 9, 2022
Traditional,
Complementary
and
Integrative
Medicine
(TCIM)
has
been
reported
to
use
for
symptom
management
of
coronavirus
disease
2019
(COVID-19).
The
objective
this
review
was
identify
the
overall
usage
prevalence
TCIM
interventions
COVID-19.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(1), P. e0295116 - e0295116
Published: Jan. 17, 2024
Background
Herbal
supplements
(HSs)
are
used
to
treat
a
variety
of
diseases
and
ailments.
Individuals
with
chronic
at
higher
risk
having
adverse
events
drug
interactions
from
the
use
HSs.
Aim
This
study
determined
beliefs,
awareness,
use,
factors
associated
HSs
usage
among
patients
in
Alkharj,
Saudi
Arabia.
Method
A
cross-sectional
was
conducted
between
February
June
2019.
Face-to-face
interviews
were
various
out-patient
clinics
different
hospitals.
Patients
diagnosed
included
study.
Data
analyzed
by
descriptive,
comparative,
inferential
statistics
using
SAS
ver.
9.4.
Results
The
participants
consisted
533
patients,
mean
age
53.6
±12.9
years.
most
prevalent
diabetes
mellitus
(67.7%),
followed
hypertension
(54.8%),
hyperlipidemia
(53.8%).
Among
studied
participants,
336
(63%)
had
least
one
HS,
whereby
commonly
ginger
(74.7%),
mint
(72%),
cumin
(66.7%).
Almost
78%
users
did
not
consult
any
healthcare
provider
about
their
use.
varied
significantly
female
male
(
p
<0.05),
61.5%
comparison
(38.5%).
Gender
(AOR
0.328;
95%
CI
0.139–0.772;
=
0.0107),
number
1.585;
1.084–2.318;
0.0312),
2.818;
1.507–5.269;
0.0.0012)
pure
patients.
Conclusion
results
this
showed
that
high
Concurrent
drugs
should
be
well-discussed
providers
avoid
potential
or
especially
diseases.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(22), P. e38289 - e38289
Published: May 31, 2024
Background:
Ginger,
a
potent
antiviral,
anti-inflammatory,
and
antioxidant
remedy,
is
potential
therapeutic
option
for
COVID-19.
However,
there
was
not
enough
clinical
evidence
about
ginger
We
evaluated
the
efficacy
safety
of
on
paraclinical
features
in
outpatients
with
Methods:
In
this
randomized
controlled
trial,
confirmed
COVID-19
were
randomly
assigned
1:1
ratio
to
receive
(1000
mg
3
times
day
7
days)
or
placebo.
The
primary
outcome
viral
clearance
after
end
intervention.
Oxygen
saturation
(S
P
O
2
),
body
temperature,
respiratory
rate
(RR),
hospital
admission,
incidence
adverse
events
also
assessed.
Results:
A
total
84
patients
(42
42
control
groups)
randomized.
statistically
improved
group
(41.6%)
compared
placebo
(42.8%).
findings
indicated
that
S
,
RR
had
no
significant
difference
between
groups
at
imaging
finding
pulmonary
infiltrate
significantly
reduced
th
intervention
group.
percentage
<96%
decreased
over
study
Moreover,
need
admission
drug
different
follow-up
period.
Conclusions:
Ginger
impact
parameters
patients.
demonstrated
safe
profile
infiltrate.
Trial
registration:
trial
registered
as
IRCT20200506047323N1.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 27, 2024
Abstract
COVID-19
is
a
global
pandemic
that
caused
dramatic
loss
of
human
life
worldwide,
leading
to
accelerated
research
for
antiviral
drug
discovery.
Herbal
medicine
one
the
most
commonly
used
alternative
prevention
and
treatment
many
conditions
including
respiratory
system
diseases.
In
this
study,
computational
pipeline
was
employed,
network
pharmacology,
molecular
docking
simulations,
dynamics
analyze
common
phytochemicals
ginger
rhizomes
identify
candidate
constituents
as
viral
inhibitors.
Furthermore,
experimental
assays
were
performed
volatile
non-volatile
compounds
assess
activity
oil
hydroalcoholic
extract.
Network
pharmacology
analysis
showed
target
genes
are
involved
in
related
cellular
processes
infection.
Docking
highlighted
five
pungent
zingiberenol
potential
inhibitors
main
protease
(M
pro
),
spike
receptor-binding
domain
(RBD),
angiotensin-converting
enzyme
2
(ACE2).
Then,
(6)-gingerdiacetate
selected
(MD)
simulations
it
exhibited
best
binding
interactions
free
energies
over
three
proteins.
Trajectories
complexes
RBD
ACE2
with
ligand
preserved
similar
patterns
root
mean
square
deviation
(RMSD)
radius
gyration
(Rg)
values
their
respective
native
structures.
Finally,
validation
extract
confirmed
existence
revealed
strong
IC
$$_{50}$$
50
2.727
$$\upmu
\hbox
{g}/\hbox
{ml}$$
μg/ml
.
Our
study
provides
insights
into
may
enhance
host
immune
response
block
ACE2,
thereby,
inhibiting
SARS-CoV-2
