Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(2), P. 395 - 408
Published: Dec. 16, 2023
Language: Английский
ERJ Open Research, Journal Year: 2025, Volume and Issue: 11(3), P. 01066 - 2024
Published: May 1, 2025
The circadian clock genes might play a key role in regulating the pathophysiological processes underlying COPD. Their other chronic lung diseases is still unclear, but important to elucidate. https://bit.ly/4f3KXQk.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 10032 - 10032
Published: Sept. 2, 2022
Circadian rhythm is associated with the aging process and sex differences; however, how age can change circadian regulation systems remains unclear. Thus, we aimed to evaluate age- sex-related changes in gene expression identify sex-specific target molecules that regulate aging. Rat livers were categorized into four groups, namely, young male, old female, of several genes involved was confirmed by silico vitro studies. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analyses showed related rhythms changed more males than females during liver In addition, differentially expressed analysis quantitative real-time polymerase chain reaction/western blotting revealed Nr1d1 Nr1d2 upregulated Furthermore, other genes, such as Arntl, Clock, Cry1/2, Per1/2, Rora/c, decreased aging; these various patterns Age-related elevation Nr1d1/2 downregulates males, but not females, Consequently, age-related upregulation may play a crucial role
Language: Английский
Citations
14
Acta Physiologica, Journal Year: 2023, Volume and Issue: 237(4)
Published: Jan. 26, 2023
Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS) with increasing incidence prevalence. MS associated metabolic disturbances that, as preliminary human animal data suggest, might be mediated by disruption circadian rhythmicity. Nutrition habits can influence risk for MS, dietary interventions may effective in modulating course. Chronotherapeutic approaches such time-restricted eating (TRE) benefit people stabilizing clock restoring immunological rhythms, thus potentially counteracting progression. This review provides a summary selected studies on intervention their including gene variations, hormones, retino-hypothalamic tract changes. Furthermore, we present that reported diurnal variations which result from disruption. And lastly, suggest how chrononutritive like TRE counteract activity.
Language: Английский
Citations
9
Cardiology and Therapy, Journal Year: 2023, Volume and Issue: 12(2), P. 275 - 295
Published: May 16, 2023
Stroke remains one of the leading causes mortality and long-term permanent disability worldwide despite technological innovations developments in pharmacotherapy. In last few decades, growing data have evidenced role circadian system brain vulnerability to damage, development evolution stroke, short-term recovery. On other hand, stroke itself can affect via direct injury specific structures involved regulation (i.e., hypothalamus, retinohypothalamic tracts, etc.) impairment endogenous regulatory mechanisms, metabolic derangement, a neurogenic inflammatory response acute stroke. Moreover, disruption rhythms occur or exacerbate as result exogenous factors related hospitalization itself, conditions intensive care unit ward (light, noise, etc.), medication (sedatives hypnotics), loss external entraining rhythms. phase patients demonstrate abnormal variations biomarkers (melatonin, cortisol), core body temperature, rest–activity patterns. The approaches aimed at restoration disrupted patterns include pharmacological (melatonin supplementation) non-medication (bright light therapy, shifting feeding schedules, interventions; however, their effects on short- recovery after are not well understood.
Language: Английский
Citations
9
Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(2), P. 395 - 408
Published: Dec. 16, 2023
Language: Английский
Citations
8