Microbiota modulation for infectious complications following allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: March 14, 2025

The intervention of microbiota modulation in the treatment infection complications after allogeneic hematopoietic stem cell transplantation pediatric patients with hematological malignancies has shown potential benefits. Through use probiotics, prebiotics, synbiotics, and fecal (FMT), these interventions modulate gut enhance immune function to prevent treat infections. They have been reduce incidence diarrhea intestinal infections, mitigate issue antibiotic resistance, promote recovery microbiota. Future research is needed further assess safety efficacy establish standardized protocols.

Language: Английский

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The Challenge of Overcoming Antibiotic Resistance in MDR Gram-Negative Bacteria: “Attack on Titan”

Published: July 11, 2023

The global burden of bacterial resistance remains one the most serious public health concerns. Infections caused by multiresistant (MDR) bacteria in critically ill patients require immediate empirical treatment, which may not only be ineffective due to MDR multiple classes antibiotics, but also contribute selection and spread antimicrobial resistance. Both WHO ECDC consider carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas aeruginosa (CRPA) Acinetobacter baumannii (CRAB) highest priority. ability form biofilm acquisition drug resistance, particular carbapenems, have made these pathogens particularly difficult treat. They are a growing cause healthcare-associated infections significant threat health, associated with high mortality rate. Moreover, co-colonization was found predictor for in-hospital mortality. Importantly, they potential using mobile genetic elements. Given current situation, it is clear that finding new ways combat can no longer delayed. aim this review evaluate literature on how AMR. highlights importance rational use antibiotics need implement stewardship principles prevent transmission drug-resistant organisms healthcare settings. Finally, discusses advantages limitations alternative therapies treatment "titans" antibiotic

Language: Английский

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Laterosporulin25: A probiotically produced, novel defensin-like bacteriocin and its immunogenic properties

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110500 - 110500

Published: June 21, 2023

Language: Английский

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Nutraceutical Combinational Therapy for Diarrhoea Control with Probiotic Beverages from Fermented Fruits, Vegetables and Cereals to Regain Lost Hydration, Nutrition and Gut Microbiota

Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2190 - 2190

Published: Aug. 30, 2023

This article deals with the condition of irregular bowel movements known as diarrhoea, its pathology, symptoms and aetiology. The information has been presented on causes diarrhoea that include gut infections, food intolerances allergies to certain ingredients, problems in gastrointestinal tract like irritable syndrome, inflammatory disease and, dysbiosis which occurs due long-term use antibiotics, or other medicines, etc. Most cases can be resolved without needing medical treatment; however, it is still important avoid dehydration body some supplements get necessary nutrients are lost frequent before they absorbed assimilated tract. Probiotic products reported natural therapeutic agents, reduce risk both adults children. intake dietary fluid form fermented beverages containing probiotic strains could help control. patient would achieve benefits consumption these functional three ways—by regaining fluids body, supplementing beneficial bacteria restore diversity microbiota, was disturbed well a source quick nutrition recoup energy.

Language: Английский

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The Efficacy of Probiotics, Prebiotics, and Synbiotics in Patients Who Have Undergone Abdominal Operation, in Terms of Bowel Function Post-Operatively: A Network Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 4150 - 4150

Published: June 20, 2023

Abdominal operations may lead to post-operative bowel dysfunction, while administration of probiotics, prebiotics and synbiotics limit its manifestation. Τhe study aimed assess the efficacy in patients who undergone abdominal operation, terms function post-operatively. PubMed, Scopus, Cochrane Central Register Controlled Trials (Central), Embase, US Registry clinical trials, sources grey literature were searched. The relative effect sizes estimated, we obtained ranking interventions using cumulative curves. In total, 30 studies included analysis. For outcome ileus, probiotics was superior placebo/no intervention (relative risk, RR: 0.38; 95%CI: 0.14-0.98) with highest SUCRA (surface under ranking) value (92.1%). time first flatus, (MD: -0.47; -0.78 -0.17) -0.53; -0.96 -0.09) intervention. defecation for distension hospitalization days, -3.07; -4.80 -1.34). Administration had surgery reduced prevalence defecation, distension. Synbiotics reduce flatus days.

Language: Английский

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Role and significance of virus-bacteria interactions in disease progression

Journal of Applied Microbiology, Journal Year: 2024, Volume and Issue: 135(6)

Published: June 1, 2024

Understanding disease pathogenesis caused by bacteria/virus, from the perspective of individual pathogen has provided meaningful insights. However, as viral and bacterial counterparts might inhabit same infection site, it becomes crucial to consider their interactions contributions in onset progression. The objective review is highlight importance considering both agents during course coinfection. provides a unique on general theme virus-bacteria interactions, which either lead colocalized infections that are restricted one anatomical niche, or systemic have effect human host. sequence, nature, underlying mechanisms certain been elaborated with relevant examples literature. It also attempts address various applied aspects, including diagnostic therapeutic strategies for well coinfections. aims aid researchers comprehending intricate interplay between virus bacteria progression, thereby enhancing understanding current methodologies empowering development novel health care tackle

Language: Английский

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HAMLET, a human milk protein-lipid complex, modulates amoxicillin induced changes in an ex vivo biofilm model of the oral microbiome

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

Challenges from infections caused by biofilms and antimicrobial resistance highlight the need for novel antimicrobials that work in conjunction with antibiotics minimize risk. In this study we investigated composite effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells), a human milk protein-lipid complex amoxicillin on microbial ecology using an

Language: Английский

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Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 4, 2024

Recently, the mounting integration of probiotics into human health strategies has gathered considerable attention. Although benefits have been widely recognized in patients with gastrointestinal disorders, immune system modulation, and chronic-degenerative diseases, there is a growing need to evaluate their potential risks. In this context, new concerns arisen regarding safety as some strains may adverse effects humans. Among these strains,

Language: Английский

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Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection

Metabolism, Journal Year: 2024, Volume and Issue: 161, P. 156035 - 156035

Published: Sept. 24, 2024

Language: Английский

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Impact of the host microbiota on fungal infections: New possibilities for intervention?

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 198, P. 114896 - 114896

Published: May 20, 2023

Language: Английский

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