The Influence of Dietary Factors on the Gut Microbiota

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1368 - 1368

Published: July 7, 2022

There is increasing evidence that diet influences the relationship between gut microbiota and individual health outcomes. Nutrient intake affects composition of microbial community provides metabolites influence host physiology. Dietary patterns, including macronutrient balance feeding/fasting cycles which may be manipulated with dietary regimens based on caloric restriction periods, homeostasis through its impact ecosystem. Along same line, prebiotic probiotic ingredients additives in foods, as well degree food processing have consequences related immune metabolic response human host. Acquiring knowledge these aspects, especially an -omics-integral approach, might provide basis for personalized nutritional interventions directed to avoid dysbiosis contribute prevention major chronic degenerative diseases. Despite vast scientific supporting factors function, underlying mechanisms their potential are far from clear. a lack well-designed longitudinal studies performed target population groups whose patterns can particularly relevant future health, case infants, pregnant women, or athletes.

Language: Английский

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Exploring the Potential Impact of GLP-1 Receptor Agonists on Substance Use, Compulsive Behavior, and Libido: Insights from Social Media Using a Mixed-Methods Approach

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 617 - 617

Published: June 20, 2024

Glucagon-like peptide-1 (GLP-1) is involved in a range of central and peripheral pathways related to appetitive behavior. Hence, this study explored the effects glucagon-like receptor agonists (GLP-1 RAs) on substance behavioral addictions, including alcohol, caffeine, nicotine, cannabis, psychostimulants, compulsive shopping, sex drive/libido. Data were collected from various social platforms. Keywords GLP-1 RAs substance/behavioral addiction used extract relevant comments. The employed mixed-methods approach analyze online discussions posted December 2019 June 2023 using specialized web application. Reddit entries focus here due limited data other platforms, such as TikTok YouTube. A total 5859 threads comments extracted six subreddits, which included about drugs associated brand names. To obtain posts, keywords potential use behavior selected. Further analysis two main steps: (1) manually coding posts based users’ references impact non-substance habits, excluding irrelevant or unclear comments; (2) performing thematic dataset keywords, AI-assisted techniques followed by manual revision generated themes. Second, was performed keyword-related dataset, In total, 29.75% alcohol-related; 22.22% caffeine-related; 23.08% nicotine-related clearly stated cessation intake these substances following start prescription. Conversely, mixed results found for cannabis intake, only limited, anecdotal made available cocaine, entactogens, dissociative drugs’ misuse. Regarding 21.35% reported shopping interruption, whilst sexual drive/libido elements reportedly increased several users. current appeared be useful tool gaining insight into complex topics addiction-related disorders; some RA-related mental health benefits could also inferred here. Overall, it that may show target both craving maladaptive/addictive behaviors, although further empirical research needed.

Language: Английский

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Gut Microbiome-Liver-Brain axis in Alcohol Use Disorder. The role of gut dysbiosis and stress in alcohol-related cognitive impairment progression: possible therapeutic approaches.

Neurobiology of Stress, Journal Year: 2025, Volume and Issue: 35, P. 100713 - 100713

Published: Feb. 8, 2025

The Gut Microbiome-Liver-Brain Axis is a relatively novel construct with promising potential to enhance our understanding of Alcohol Use Disorder (AUD), and its therapeutic approaches. Significant alterations in the gut microbiome occur AUD even before any other systemic signs or symptoms manifest. Prolonged inappropriate alcohol consumption, by affecting microbiota mucosa permeability, thought contribute development behavioral cognitive impairments, leading Alcohol-Related Liver Disorders potentially progressing into alcoholic cirrhosis, which often associated severe impairment related neurodegeneration, such as hepatic encephalopathy dementia. critical role further supported efficacy FDA-approved treatments for cirrhosis (i.e., lactulose rifaximin). To stimulate new research, we hypothesize that interactions between maladaptive stress response constitutional predisposition neurodegeneration underlie progression conditions Clinical Concerns impairment, represent significant costly burden society. Early identification individuals at risk developing these could help prioritize integrated interventions targeting different substrates axis. Specifically, addiction medications, modulators, stress-reducing interventions, and, possibly soon, agents reduce steatosis/fibrosis will be discussed context digitally explicit goal this treatment performed on early stage disorder would transition from those Common strategy recommended most neurological neurodegenerative disorders.

Language: Английский

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Alterations and correlations of gut microbiota, fecal, and serum metabolome characteristics in a rat model of alcohol use disorder

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 4, 2023

Growing evidence suggests the gut microbiota and metabolites in serum or fecal may play a key role process of alcohol use disorder (AUD). However, correlations both feces AUD subjects are not well understood.We established rat model by chronic intermittent ethanol voluntary drinking procedure, then syndromes, microbiota, metabolomic profiling rats were examined, between analyzed.Ethanol intake preference increased maintained at high level experimental rats. Anxiety-like behaviors was observed open field test elevated plus maze after withdraw, indicating that successfully developed. The full length 16S rRNA gene sequencing showed significantly changed β-diversity microbial communities, decreased diversity but did distinctly impact richness. Microbiota composition rats, such as abundance Romboutsia Turicibacter increased, whereas uncultured_bacterium_o_Mollicutes_RF39 decreased. In addition, untargeted metabolome analysis revealed many altered especially involved sphingolipid metabolism glycerophospholipid pathways. Finally, multiple among behavior, co-changed identified, directly correlated with preference.The important links dysbiosis can be potentially new targets for treating AUD.

Language: Английский

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Adolescent alcohol drinking interaction with the gut microbiome: implications for adult alcohol use disorder

Advances in Drug and Alcohol Research, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 15, 2024

Reciprocal communication between the gut microbiota and brain, commonly referred to as “gut-brain-axis” is crucial in maintaining overall physiological homeostasis. Gut development brain maturation (neuronal connectivity plasticity) appear be synchronized follow same timeline during childhood (immature), adolescence (expansion) adulthood (completion). It important note that mesolimbic reward circuitry develops early on, whereas of inhibitory frontal cortical neurons delayed. This imbalance can lead increased acquirement reward-seeking risk-taking behaviors adolescence, consequently eventuate heightened risk for substance abuse. Thus, there high initiation alcohol drinking significantly increases use disorder (AUD) adulthood. The underlying causes AUD are not well understood. suggested alcohol-associated impairment plays a key role neurodevelopment Furthermore, alcohol-induced dysregulation microglia, either directly or indirectly through interaction with microbiota, may critical neuroinflammatory pathway leading neurodevelopmental impairments AUD. In this review article, we highlight influence adolescent on gut-brain axis eventual manifestation novel therapeutic interventions via manipulations discussed briefly.

Language: Английский

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Microbiome Dysbiosis, Dietary Intake and Lifestyle-Associated Factors Involve in Epigenetic Modulations in Colorectal Cancer: A Narrative Review

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

Background: Colorectal cancer is the second cause of mortality and third most commonly diagnosed worldwide. Current data available implicate epigenetic modulations in colorectal development. The health large bowel impacted by gut microbiome dysbiosis, which may lead to colon rectum cancers. release microbial metabolites toxins these microbiotas has been shown activate processes leading Increased consumption a ‘Westernized diet’ certain lifestyle factors such as excessive alcohol have associated with cancer. Purpose: In this review, we seek examine current knowledge on involvement microbiota, dietary factors, development through modulations. Methods: A review several published articles focusing mechanism how changes microbiome, diet, contribute potential using biomarkers for diagnosis. Conclusions: This presents scientific findings that provide hopeful future manipulating patients’ management care.

Language: Английский

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Intestinal microbiome dysbiosis in alcohol-dependent patients and its effect on rat behaviors

mBio, Journal Year: 2023, Volume and Issue: 14(6)

Published: Nov. 14, 2023

Intestinal microbiome dysbiosis is associated with psychiatric disease through the "microbiota-gut-brain" axis. Here, we revealed that there was obvious intestinal (including bacterial and fungal) in alcohol-dependent patients. Alcohol consumption seriously disturbs gut equilibrium between bacteria fungi, reduces interactions among bacterial-fungal trans-kingdom, increases permeability. Gut microbiota should be considered as a whole to study development of alcohol dependence. The patients increased anxiety- depression-like behavior rats. may promote dependence by regulating endogenous cholecystokinin (CCK) related receptors. Hence, balance CCK potential strategy for reducing risk relapse addiction

Language: Английский

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Chronic binge drinking-induced susceptibility to colonic inflammation is microbiome-dependent

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 20, 2024

Alterations in intestinal permeability and the gut microbiome caused by alcohol abuse are associated with alcoholic liver disease worsening of inflammatory bowel diseases (IBD) symptoms. To resolve direct effects chronic ethanol consumption on colon its absence acute or alcohol-induced disease, we developed a mouse model binge drinking that uncovers how may enhance susceptibility to colitis via microbiota. Employing daily gavage, recapitulate key features consumption. We found worsens infection, colonic injury inflammation, this effect persists beyond period. Using gnotobiotics, showed alcohol-driven is microbiota-dependent transferable ethanol-naïve mice transplantation.

Language: Английский

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A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues

Alcohol Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 47(1), P. 36 - 44

Published: Nov. 22, 2022

Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk morbidity mortality in people alcohol use disorders. Organ-specific cells, including microglia brain, alveolar macrophages lungs, Kupffer cells liver, play vital functions host defense through tissue repair maintenance homeostasis. However, binge drinking chronic impair these cells' abilities regulate inflammatory signaling metabolism, thus contributing dysfunction. Further complicating delicate systems, cell is exacerbated by aging gut barrier leakage. This critical review describes recent advances elucidating potential mechanisms leads derangements immunity highlights current gaps knowledge that may be focus future investigations.

Language: Английский

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The diversity of the intestinal microbiota in patients with alcohol use disorder and its relationship to alcohol consumption and cognition

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 22, 2022

Alcohol use disorder (AUD) has evolved into a severe social and medical issue. However, the exact environmental factors triggering AUD pathophysiology remain unknown. A growing body of research shown that elements can affect brain via microbiota-gut-brain axis.We employed 16S rRNA gene sequencing technology to investigate composition diversity intestinal microbiota in 32 males 35 healthy controls (HCs), as well its relationship on cognitive function.Our findings showed alpha indices AUDs were much lower than HCs. The abundances Faecalibacterium, Gemmiger, Lachnospiracea_incertae_sedis, Megamonas, Escherichia significantly different between HC groups could be used basis for judging whether excessive drinking. Escherichia, Fusobacterium judge function population.These data suggested gut dysbiosis patients, some specific considered related alcohol intake function. This study provides important information further pathogenesis from perspective microbiota.

Language: Английский

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