Gut microbiota and kidney diseases. Literature review DOI
Evgeny Shutov, Bolshakov S.A. Bolshakov,

Tatyana A Makarova

et al.

Nephrology and Dialysis, Journal Year: 2024, Volume and Issue: 26(3), P. 283 - 302

Published: Sept. 20, 2024

Recent technological advances have significantly enhanced our understanding of the role microbial communities play in human body. The gut microbiota, one most diverse microbiomes, consists over 35,000 bacterial species and 10 million genes, leading researchers to consider it as an additional organ. This whiles relatively stable within each individual highly influenced by exogenous endogenous factors. Collectively, microbiota functions a "second genome", profoundly impacting host’s metabolic pathways regulating body’s complex homeostatic balance. Research into "microbe–host" interaction, both health disease, has garnered worldwide scientific. In chronic kidney disease (CKD), undergoes significant changes, growing evidences suggests that dysbiosis plays crucial progression renal failure. Key pathological process, such production gut-derived uremic toxins, decreased synthesis short– chain fatty acids, altered intestinal pH, compromised barrier function, heightened systemic inflammation, are all linked microbiota. However, relationship between these changes pathogenesis requires further investigation. Advances microbiome research, including metagenomic metatranscriptomic analyses, alongside proteomic, metabolomics, immunomic studies, greatly expanded microbiomal community structure functions. These technologies, coupled with mechanistic experiments model systems, deepened knowledge how influences metabolism. Current research aims explore bidirectional host, identifying potential interventions could help restore mutualistic relationship.

Language: Английский

Gut Microbiota in Chronic Kidney Disease: From Composition to Modulation towards Better Outcomes—A Systematic Review DOI Open Access
Luminița Voroneanu, Alexandru Burlacu, Crischentian Brinza

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(5), P. 1948 - 1948

Published: March 1, 2023

Background: A bidirectional kidney–gut axis was described in patients with chronic kidney disease (CKD). On the one hand, gut dysbiosis could promote CKD progression, but on other studies reported specific microbiota alterations linked to CKD. Therefore, we aimed systematically review literature composition patients, including those advanced stages and end-stage (ESKD), possibilities shift microbiota, its impact clinical outcomes. Materials methods: We performed a search MEDLINE, Embase, Scopus, Cochrane databases find eligible using pre-specified keywords. Additionally, key inclusion exclusion criteria were pre-defined guide eligibility assessment. Results: retrieved 69 which met all analyzed present systematic review. Microbiota diversity decreased as compared healthy individuals. Ruminococcus Roseburia had good power discriminate between controls (AUC = 0.771 AUC 0.803, respectively). abundance consistently especially ESKD (p < 0.001). model based 25 dissimilarities an excellent predictive for diabetic nephropathy 0.972). Several patterns observed deceased survivor group (increased Lactobacillus, Yersinia, Bacteroides Phascolarctobacterium levels). associated peritonitis enhanced inflammatory activity. In addition, some documented beneficial effect flora attributed synbiotic probiotic therapies. Large randomized trials are required investigate of different modulation strategies microflora subsequent Conclusions: Patients altered microbiome profile, even at early stages. Different genera species levels be used models individuals increased mortality risk identified through analysis. Modulation therapy warranted.

Language: Английский

Citations

32
Causal effects between gut microbiota and IgA nephropathy: a bidirectional Mendelian randomization study DOI Creative Commons

Feihong Ren,

Qiubai Jin, Tongtong Liu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 2, 2023

Therapeutic approaches that target the gut microbiota (GM) may be helpful in potential prevention and treatment of IgA nephropathy (IgAN). Meanwhile, relevant studies demonstrated a correlation between GM IgAN, however, these confounding evidence cannot prove causal relationship IgAN.Based on data from genome-wide association study (GWAS) MiBioGen IgAN GWAS FinnGen research. A bi-directional Mendelian randomization (MR) was performed to explore IgAN. We used inverse variance weighted (IVW) method as primary determine exposure outcome our MR study. Besides, we additional analysis (MR-Egger, median) sensitivity (Cochrane's Q test, MR-Egger MR-PRESSO) select significant results, followed by Bayesian model averaging (MR-BMA) test results Finally, reverse conducted estimate probability causality.At locus-wide significance level, IVW showed Genus Enterorhabdus protective factor for [OR: 0.456, 95% CI: 0.238-0.875, p=0.023], while butyricicoccus risk 3.471, 1.671-7.209, p=0.0008]. In analysis, no pleiotropy or heterogeneity found.Our revealed expanded variety bacterial taxa causally related These could become novel biomarkers facilitate development targeted therapies developing understanding "gut-kidney axis".

Language: Английский

Citations

27
Gut microbiota and its metabolites – molecular mechanisms and management strategies in diabetic kidney disease DOI Creative Commons

Zi‐Hui Mao,

Zhong‐Xiuzi Gao, Dongwei Liu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 19, 2023

Diabetic kidney disease (DKD) is one of the major microvascular complications diabetes mellitus and also serious risk factors in cardiovascular events, end-stage renal disease, mortality. DKD associated with diversified, compositional, functional alterations gut microbiota. The interaction between microbiota host mainly achieved through metabolites, which are small molecules produced by microbial metabolism from exogenous dietary substrates endogenous compounds. plays a critical role pathogenesis producing multitudinous metabolites. Nevertheless, detailed mechanisms its metabolites involved occurrence development have not been completely elucidated. This review summarizes specific classes microbiota-derived aims to explore molecular pathophysiology progression, recognizes biomarkers for screening, diagnosis, prognosis DKD, as well provides novel therapeutic strategies DKD.

Language: Английский

Citations

25
Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota DOI Creative Commons
Xiaqing Wu, Lei Zhao,

Yanlong Zhao

et al.

Pharmaceutical Biology, Journal Year: 2024, Volume and Issue: 62(1), P. 423 - 435

Published: May 17, 2024

Context Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal that requires replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect human evolution, plays a crucial role in this condition. Traditional Chinese medicine (TCM) has shown promising outcomes ameliorating DKD by addressing the microbiota.

Language: Английский

Citations

9
Gut microbiota composition links to variation in functional domains across psychiatric disorders DOI
Danique Mulder, Babette Jakobi, Yingjie Shi

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 120, P. 275 - 287

Published: May 28, 2024

Language: Английский

Citations

7
Molecular mechanisms of gut microbiota in diabetic nephropathy DOI
Gang Cheng, Yulin Liu,

Rong Guo

et al.

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 213, P. 111726 - 111726

Published: June 4, 2024

Language: Английский

Citations

7
Association of dietary live microbe intake with diabetic kidney disease in patients with type 2 diabetes mellitus in US adults: a cross-sectional study of NHANES 1999–2018 DOI Creative Commons
Min Wang, Zhaohui Huang,

Yonghong Zhu

et al.

Acta Diabetologica, Journal Year: 2024, Volume and Issue: 61(6), P. 705 - 714

Published: Feb. 24, 2024

Abstract Aims Several studies have reported dietary microorganisms’ beneficial effects on human health. We aimed to detect the potential association between live microbe intake and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) through a cross-sectional analysis of National Health Nutrition Examination Survey from 1999 2018. Methods According Sanders classification system microbes, study participants were divided into three groups: low, medium, high groups. In T2DM, DKD was assessed by glomerular filtration rate (< 60 mL/min/1.73 m using Chronic Kidney Disease Epidemiology Collaboration algorithm), proteinuria (urinary albumin creatinine ratio ≥ 30 mg/g), or both. Weighted univariate multivariate logistic regression subgroup analyses conducted investigate independent DKD. Results The included 3836 participants, whom 1467 (38.24%) had for diagnosis. Our demonstrated that group more likely be older, female, non-Hispanic White, higher education levels, lower prevalence smoking, poverty-income ratio, energy intake, haemoglobin (HbA1c) serum risk progression. After adjustment covariates, low DKD, whereas no significant found medium No statistically interaction observed all except HbA1c ( p < 0.05). Conclusions results indicate associated prevalence.

Language: Английский

Citations

4
The Role and Mechanism of Gut Microbiota in the Development of Diabetic Nephropathy DOI

梅 韩

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 215 - 222

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhanced trimethylamine metabolism and gut dysbiosis in type 2 diabetes mellitus with microalbumin DOI Creative Commons

Lixia Huo,

Hui Li,

Zhu Ming

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 20, 2023

Background Abnormal gut microbiota and blood trimethylamine-N-oxide (TMAO) metabolome have been reported in patients with type 2 diabetes mellitus (T2DM) advanced diabetic nephropathy. This study aimed to investigate the profiles a group of targeted urine metabolic characteristics T2DM or without microalbuminuria, determine correlation between composition, trimethylamine (TMA) metabolism, clinical features during progression kidney disease (DKD) Methods included 26 microalbuminuria (Micro), normoalbuminuria (Normo), 15 healthy controls (HC). Urine Fecal samples were detected using ultra performance liquid chromatography tandem mass spectrometry 16S ribosomal DNA gene sequencing, respectively. Results The TMAO/TMA ratio decreased gradually HC-Normo-Micro transition. levels TMA, choline betaine significantly different HC belonging both Normo Micro groups. At operational taxonomic unit (OTU) level, microflora diversity was reduced groups compared Taxonomic analyses revealed significant consumption relative abundances eight bacterial genera enrichment two Furthermore, six genera, namely, Ruminococcus_1, [Eubacterium]_ruminantium_group, Roseburia, Faecalibacterium, Fusicatenibacter Coprococcus_3 exhibited differences, associated elevated urinary albumin creatinine (UACR), TMAO/TMA, TMA its precursors other Conclusion imbalance has occurred early-stage DKD, short-chain fatty acid-producing bacteria accumulation UACR.

Language: Английский

Citations

10
Alterations of the gut microbiota in patients with diabetic nephropathy and its association with the renin-angiotensin system DOI

Fatemeh Zali,

Abdorrahim Absalan, Golnaz Bahramali

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 20, 2025

Language: Английский

Citations

0