THE MIND - Bulletin on Mind-Body Medicine Research, Journal Year: 2023, Volume and Issue: 2, P. 5 - 6
Published: July 2, 2023
Language: Английский
Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107394 - 107394
Published: Sept. 3, 2024
Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a crucial role in maintaining metabolic balance and preventing insulin resistance, both key factors type 2 diabetes mellitus (T2DM) development. When mitophagy malfunctions diabetic neuropathy, it triggers cascade disruptions, including reduced energy production, increased oxidative stress, cell death, ultimately leading to various complications. Thus, targeting enhance may have emerged as promising therapeutic strategy for T2DM its Notably, plant-derived compounds with β-cell protective mitophagy-stimulating properties offer potential novel agents. This review highlights intricate mechanisms linking dysfunction complications, particularly elucidating interventions this debilitating disease.
Language: Английский
Citations
5
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102734 - 102734
Published: March 1, 2025
Language: Английский
Citations
0
Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 146 - 146
Published: Jan. 23, 2025
An organism is considered “alive” if it can grow, reproduce, respond to external stimuli, metabolize nutrients, and maintain stability. By this definition, both mitochondria viruses exhibit the key characteristics of independent life. In addition their capacity for self-replication under specifically defined conditions, communicate via shared biochemical elements, alter cellular energy metabolism, adapt local environment. To explain phenomenon, we hypothesize that early viral prototype species evolved from ubiquitous environmental DNA gained within coacervate-like liquid droplets. The high mutation rates experienced in environment streamlined acquisition standard genetic codes adaptation a diverse set host environments. Similarly, mitochondria, eukaryotic intracellular organelles generate resolve oxygen toxicity, originally an infectious bacterial active functionality extracellular space. Thus, while contribute profoundly homeostasis, freestanding existence may lead functional disruptions over time, notably, overproduction reactive species, phenomenon strongly linked aging-related disorders. Overall, more in-depth understanding full extent evolution primordial precursors novel insights therapeutic strategies address neurodegenerative processes promote healthy aging.
Language: Английский
Citations
0
BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)
Published: May 9, 2025
Heat stress seriously affects the production and health of dairy cows is a key factor limiting sustainable development industry. DNA methylation serves as an important epigenetic regulatory mechanism closely associated with animal's response to heat stress. However, specific molecular in cows' not fully understood. In this study, whole genome bisulfite sequencing analysis blood identified 49861 differentially methylated regions corresponding 7613 genes between spring summer cows. Among them, 4069 promoter region were significantly enriched biological pathways such substance transport, reactive oxygen species metabolism, signal transduction, energy metabolism. By integrating expression data genes, 157 further screened, their levels negatively correlated gene expression. The changes DNLZ, GNAS, SMAD5 most significant, network showed that DNLZ has high connectivity protein-protein interaction network, indicating its potential function response. Experimental verification shows under conditions, level CpG islands increases, level. Dual-luciferase reporter assays using constructs containing experiment confirms inhibits transcriptional activity, higher degree methylation, stronger inhibitory effect. research results provide new insights into stress-related cows, clarify roles target markers for cultivation heat-resistant
Language: Английский
Citations
0
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: June 21, 2024
The rapid development of the COVID-19 pandemic resulted in a closer analysis cell functioning during β-coronavirus infection. This review will describe evidence for as syndrome with strong, albeit still underestimated, mitochondrial component. Due to sensitivity host mitochondria coronavirus infection, SARS-CoV-2 affects signaling, modulates immune response, modifies cellular energy metabolism, induces apoptosis and ageing, worsening symptoms which can sometimes be fatal. Various aberrations across human systems tissues their relationships were reported. In this review, particular attention is given characterization multiple alterations gene expression pattern metabolism COVID-19; complexity interactions between proteins presented. participation mitogenome fragments signaling occurrence subgenomic RNA within membranous compartments, including widely discussed. As severely quality system mitochondria, background dynamics additionally characterized. Finally, perspectives on mitigation by affecting biogenesis numerous compounds therapeutic treatments are briefly outlined.
Language: Английский
Citations
3
Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)
Published: Oct. 17, 2024
Language: Английский
Citations
3
Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)
Published: Oct. 29, 2024
Neurotropic pathogens, notably, herpesviruses, have been associated with significant neuropsychiatric effects. As a group, these pathogens can exploit molecular mimicry mechanisms to manipulate the host central nervous system their advantage. Here, we present systematic computational approach that may ultimately be used unravel protein-protein interactions and processes not yet solved experimentally. Toward this end, validate by replicating set of pre-existing experimental findings document structural functional similarities shared human cytomegalovirus-encoded UL144 glycoprotein tumor necrosis factor receptor superfamily member 14 (TNFRSF14). We began thorough exploration Homo sapiens protein database using Basic Local Alignment Search Tool (BLASTx) identify proteins sharing sequence homology UL144. Subsequently, AlphaFold2 predict independent three-dimensional structures TNFRSF14. This was followed comprehensive comparison facilitated Distance-Matrix Foldseek. Finally, AlphaFold-multimer PPIscreenML elucidate potential complexes confirm predicted binding activities both then our in silico replicate finding revealed TNFRSF14 B- T-lymphocyte attenuator (BTLA) domain BTLA alone. framework offers promise identifying between pathogen-encoded counterparts. information will provide valuable insights into cognitive underlying effects viral infections.
Language: Английский
Citations
1
THE MIND - Bulletin on Mind-Body Medicine Research, Journal Year: 2024, Volume and Issue: 3
Published: Dec. 12, 2024
Conclusion:A Charité MBM course has shown beneficial effects to reduce perceived negative stress, increase self-awareness, mindfulness and empathy as well promote integrative concepts of doctor-patient relationship.Further research including RCT trials are needed validate the benefits courses for medical students in a larger study population
Language: Английский
Citations
1
Research and Practical Medicine Journal, Journal Year: 2024, Volume and Issue: 11(1), P. 40 - 53
Published: Feb. 16, 2024
Nowadays, there is a new concept that says mitochondria naturally circulate in the blood and this characteristic of both human animal bodies. It believed circulating can easily pass through tissue barriers due to their small size (50–400 nm). The phenomenon mitochondrial intercellular transfer, which bidirectional, has been observed vitro vivo , under physiological pathophysiological conditions, among variety cells, including malignant tumor cells. Circulating cell-free intact are thought play an active biological role, as already known be systemic mediators communication, transmitting hereditary non-hereditary components, MtDN A. Mitochondrial components cellular origin, DNA, were detected extracellular space. There about 50,000 times more copies genome than nuclear plasma healthy people. researchers confirmed DNA (McfDNA) stable enough for detection quantification, implying structures protecting these molecules. genome, released recognized biomarker stress signal transduction. McfDNA become attractive because its potential use diagnostic programs various diseases, e. g., diabetes, acute myocardial infarction, cancer. no doubt body fluids opens up promising scientific direction biology medicine. article analyzes modern data devoted proving existence mitochondria, functions outside cell value.
Language: Английский
Citations
0
THE MIND - Bulletin on Mind-Body Medicine Research, Journal Year: 2024, Volume and Issue: 4, P. 3 - 5
Published: May 29, 2024
When I agreed to write an editorial about Mind-Body Medicine for "The Mind", knew it would have be a personal story, my story.There is plenty of excellent research in the field and there cannot serious doubt that this holistic approach health disease has fundamental benefits chronically ill patients.So, what could contribution Bulletin Research?Possibly best offer story.While writing these lines, mid-May snowing!I see snowflakes dancing mountain tops are white, however, every once while, sun peeks out clouds reveals ocean as blue ever.The view window stunningacross Tromsø sound, towards mountains Kvaløya, Whale-Island.
Language: Английский
Citations
0