Extracellular Vehicles from Commensal Skin Malassezia restricta Inhibit Staphylococcus aureus Proliferation and Biofilm Formation DOI
Xin Liu, Xiaoyu Guo, Xiaomin Su

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(2), P. 624 - 637

Published: Jan. 31, 2024

The colonizing microbiota on the body surface play a crucial role in barrier function. Staphylococcus aureus (S. aureus) is significant contributor to skin infection, and utilization of colonization resistance commensal microorganisms counteract invasion pathogens viable approach. However, most studies have focused bacteria, with limited research fungal communities pathogenic bacteria. Extracellular vehicles (EVs) an important microbial niches interaction between distinct strains. This paper explores impact Malassezia restricta (M. restricta), fungus that dominates normal healthy microbiota, proliferation S. by examining distribution disparities two microorganisms. Based extraction EVs, bacterial growth curve, biofilm formation, it was determined EVs M. effectively suppressed formation aureus. presence diverse metabolites identified as primary factor responsible for inhibition aureus, specifically relation glycerol phospholipid metabolism, ABC transport, arginine synthesis. These findings offer valuable experimental evidence understanding symbiosis interactions within skin.

Language: Английский

Medical Device-Associated Infections Caused by Biofilm-Forming Microbial Pathogens and Controlling Strategies DOI Creative Commons
Akanksha Mishra, Ashish Aggarwal, Fazlurrahman Khan

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 623 - 623

Published: July 4, 2024

Hospital-acquired infections, also known as nosocomial include bloodstream surgical site skin and soft tissue respiratory tract urinary infections. According to reports, Gram-positive Gram-negative pathogenic bacteria account for up 70% of infections in intensive care unit (ICU) patients. Biofilm production is a main virulence mechanism distinguishing feature bacterial pathogens. Most pathogens develop biofilms at the solid-liquid air-liquid interfaces. An essential requirement biofilm presence conditioning film. A film provides first surface on which can adhere fosters growth by creating favorable environment. The improves microbial adherence delivering chemical signals or generating microenvironments. Microorganisms use this coating nutrient source. gathers both inorganic organic substances from its surroundings, these are generated microbes These nutrients boost initial adhering facilitate formation acting food Coatings with combined antibacterial efficacy antifouling properties provide further benefits preventing dead cells debris surfaces. In present review, we address numerous that form surfaces biomedical devices. addition, explore several efficient smart antiadhesive coatings device-relevant materials manage caused biofilm-forming

Language: Английский

Citations

31
Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review DOI Creative Commons
Wubetu Yihunie, Melese Getachew, Bantayehu Addis Tegegne

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 16, 2024

Antibacterial drug resistance poses a significant challenge to modern healthcare systems, threatening our ability effectively treat bacterial infections. This review aims provide comprehensive overview of the types and mechanisms antibacterial resistance. To achieve this aim, thorough literature search was conducted identify key studies reviews on mechanisms, strategies next-generation antimicrobials contain antimicrobial In review, major with examples including target site modifications, decreased influx, increased efflux pumps, enzymatic inactivation antibacterials has been discussed. Moreover, biofilm formation, horizontal gene transfer methods also included. Furthermore, measures (interventions) taken control have discussed in detail. Overall, provides valuable insights into diverse employed by bacteria resist effects drugs, aim informing future research guiding stewardship efforts.

Language: Английский

Citations

21
Biofilm Battle: New transformative tactics to tackle the bacterial biofilm infections DOI
Aditya Upadhyay, Neha Jaiswal, Awanish Kumar

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 199, P. 107277 - 107277

Published: Jan. 5, 2025

Language: Английский

Citations

4
A review of chemical signaling pathways in the quorum sensing circuit of Pseudomonas aeruginosa DOI
Kayeen Vadakkan, Ajit Kumar Ngangbam, Kuppusamy Sathishkumar

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127861 - 127861

Published: Nov. 7, 2023

Language: Английский

Citations

41
The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy DOI Creative Commons
Asiyeh Avakh, Gary Grant, Matthew James Cheesman

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(8), P. 1304 - 1304

Published: Aug. 9, 2023

Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its multidrug resistance (MDR) phenotype, leading severe and life-threatening infections. This bacterium exhibits both intrinsic various antipseudomonal agents acquired against nearly all available antibiotics, contributing MDR phenotype. Multiple mechanisms, including enzyme production, loss of outer membrane proteins, target mutations, efflux systems, contribute antimicrobial resistance. The importance addressing in P. is paramount, one pivotal determinant the resistance-nodulation-division (RND) family drug/proton antiporters, notably Mex pumps. These pumps function as crucial defenders, reinforcing emergence extensively drug-resistant (XDR) pandrug-resistant (PDR) strains, which underscores urgency situation. Overcoming this necessitates exploration development potent pump inhibitors (EPIs) restore efficacy existing drugs. By effectively countering or bypassing activities, EPIs hold tremendous potential for restoring antibacterial activity other Gram-negative pathogens. review focuses on concurrent MDR, highlighting significance pumps, particularly driving MDR. It explores promising delves into structural characteristics MexB subunit substrate binding sites.

Language: Английский

Citations

30
Relationship between biofilm formation and antibiotic resistance of Klebsiella pneumoniae and updates on antibiofilm therapeutic strategies DOI Creative Commons
Lifeng Li, Xueyan Gao, Mingchao Li

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 23, 2024

Klebsiella pneumoniae is a Gram-negative bacterium within the Enterobacteriaceae family that can cause multiple systemic infections, such as respiratory, blood, liver abscesses and urinary systems. Antibiotic resistance global health threat K. warrants special attention due to its most modern day antibiotics. Biofilm formation critical obstruction enhances antibiotic of . However, knowledge on molecular mechanisms biofilm relation with in limited. Understanding correlation crucial for providing insight design new drugs control treat biofilm-related infections. In this review, we summarize recent advances genes contributing , progress relationship between resistance, therapeutic strategies targeting biofilms. Finally, discuss future research directions target priority pathogen.

Language: Английский

Citations

16
Biofilm therapy for chronic wounds DOI Creative Commons
Yang Liu,

ShengYong Long,

Hanfeng Wang

et al.

International Wound Journal, Journal Year: 2024, Volume and Issue: 21(2)

Published: Feb. 1, 2024

Abstract Chronic wounds have been a major factor of serious harm to global public health. At present, it is known that almost all chronic contain biofilms, which seriously hinder the healing process. Removal biofilms can effectively promote wounds. As study wound deepens, many new treatment methods emerged, thus bringing revolutionary means for biofilm. This review summarizes various biofilm worldwide provide theoretical summary and practical basis selection suitable in clinical practice.

Language: Английский

Citations

14
A critical review of irrigation water quality index and water quality management practices in micro-irrigation for efficient policy making DOI Creative Commons
Geophry Wasonga Anyango, Gourav Dhar Bhowmick,

Niharika Sahoo Bhattacharya

et al.

Desalination and Water Treatment, Journal Year: 2024, Volume and Issue: 318, P. 100304 - 100304

Published: April 1, 2024

Language: Английский

Citations

13
Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm DOI
Anmol Srivastava, Nidhi Verma, Vivek Kumar

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(5)

Published: April 14, 2024

Language: Английский

Citations

12
Discovery of Melittin as Triple-Action Agent: Broad-Spectrum Antibacterial, Anti-Biofilm, and Potential Anti-Quorum Sensing Activities DOI Creative Commons
Yang Hong-yan, Rong Ma,

Jiarou Chen

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 558 - 558

Published: Jan. 23, 2024

The development of antibiotic-resistant microorganisms is a major global health concern. Recently, there has been an increasing interest in antimicrobial peptides as therapeutic option. This study aimed to evaluate the triple-action (broad-spectrum antibacterial, anti-biofilm, and anti-quorum sensing activities) melittin, membrane-active peptide present bee venom. minimum inhibitory concentration bactericidal melittin were determined using microdilution method agar plate counting. Growth curve analysis revealed that showed concentration-dependent antibacterial activity. Scanning electron microscope treatment altered morphology. Confocal laser scanning increased membrane permeability intracellular ROS generation bacteria, all which contribute bacterial cell death. In addition, crystal violet (CV) assay was used test anti-biofilm CV demonstrated inhibited biofilm formation eradicated mature biofilms. Biofilm mediated by quorum (QS) plays role this regard, so molecular docking dynamics confirmed interacts with LasR receptors through hydrogen bonds, further evaluates anti-QS activity production virulence factors (pyocyanin, elastase, rhamnolipid), exopolysaccharides secretion, motility, may be key inhibiting mechanism. findings highlight promising broad-spectrum agent, potential QS inhibitor, providing new perspective theoretical basis for alternative antibiotics.

Language: Английский

Citations

10