Indole metabolites and colorectal cancer: Gut microbial tryptophan metabolism, host gut microbiome biomarkers, and potential intervention mechanisms

Microbiological Research, Journal Year: 2023, Volume and Issue: 272, P. 127392 - 127392

Published: April 25, 2023

Language: Английский

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Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(11), P. 101798 - 101798

Published: Oct. 30, 2024

Language: Английский

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Exploring substrate–microbe interactions: a metabiotic approach toward developing targeted synbiotic compositions

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 1, 2024

Gut microbiota is an important modulator of human health and contributes to high inter-individual variation in response food pharmaceutical ingredients. The clinical outcomes interventions with prebiotics, probiotics, synbiotics have been mixed often unpredictable, arguing for novel approaches developing microbiome-targeted therapeutics. Here, we review how the gut determines fate individual responses dietary xenobiotic compounds via its immense metabolic potential. We highlight that microbial metabolites play a crucial role as targetable mediators microbiota-host relationship. With this mind, expand concept beyond prebiotics' facilitating growth engraftment by focusing on metabolism vital mode action thereof. Consequently, discuss synbiotic compositions enable guided or co-formulated ingredients specific microbes leading target molecules beneficial functions. A workflow develop presented, including selection promising (e.g. equol, urolithin A, spermidine, indole-3 derivatives), identification suitable substrates producer strains applying bioinformatic tools, models, eventually trials.

Language: Английский

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Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

Food Chemistry, Journal Year: 2024, Volume and Issue: 454, P. 139798 - 139798

Published: May 22, 2024

Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, we interrogated whether bioactivity relates to microbial metabolites derived from aromatic amino acids, termed aryl-lactates. Using targeted metabolomics, established presence aryl-lactates in commercially available foods. After pinpointing food-associated lactic acid bacteria that produce high levels aryl-lactates, identified fermentation conditions increase aryl-lactate production matrices up 5 × 10

Language: Английский

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Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease

Circulation Research, Journal Year: 2023, Volume and Issue: 132(12), P. 1674 - 1691

Published: June 8, 2023

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction underlies the leading causes of morbidity mortality, both within United States worldwide. Commensal microbiota are implicated in development cardiometabolic disease. Evidence suggests that microbiome is relatively variable during infancy early childhood, becoming more fixed later childhood adulthood. Effects microbiota, development, life, may induce changes host metabolism modulate risk mechanisms predispose toward In this review, we summarize factors influence gut composition function life explore how microbial throughout life. We highlight limitations current methodology approaches outline state-of-the-art advances, which improving research building refined diagnosis treatment options microbiome-targeted therapies.

Language: Английский

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Lactiplantibacillus plantarum-Derived Indole-3-lactic Acid Ameliorates Intestinal Barrier Integrity through the AhR/Nrf2/NF-κB Axis

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Our previous studies have shown that Lactiplantibacillus plantarum DPUL-S164-derived indole-3-lactic acid (ILA) ameliorates intestinal epithelial cell barrier injury by activating aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related 2 (Nrf2) signaling pathways promoting tight junction protein expression. This study further explored the crucial substances of L. DPUL-S164 in alleviating damage mice through a dextran sodium sulfate-induced ulcerative colitis mouse model. Compared to dead (D-S164), live (S164) its tryptophan metabolite, ILA, showed an effective ameliorating effect on treated antibiotic cocktail sulfate, suggesting are extracellular metabolites. Furthermore, S164 ameliorate suppress inflammation AhR–Nrf2 pathway inhibiting kappa-B (NF-κB) pathway. These results suggest mice, primarily producing ILA as ligand activate AhR

Language: Английский

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A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114891 - 114891

Published: Nov. 1, 2024

Diet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic (KD) as model to dissect these complex interactions. A KD rescued experimental encephalomyelitis (EAE) mouse of multiple sclerosis in microbiota-dependent fashion. Dietary supplementation with single KD-dependent metabolite (β-hydroxybutyrate [βHB]) EAE, whereas transgenic mice unable produce βHB intestine developed more severe disease. Transplantation βHB-shaped gut microbiota was protective. Lactobacillus sequence variants were associated decreased T helper 17 cell activation vitro. Finally, isolated an L. murinus strain that protected which phenocopied by enriched supplementation, indole lactate. Thus, alters immunomodulatory potential shifting metabolism, emphasizing utility taking integrative approach study diet-host-microbiome

Language: Английский

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Integrating uterine microbiome and metabolome to advance the understanding of the uterine environment in dairy cows with metritis

Animal Microbiome, Journal Year: 2024, Volume and Issue: 6(1)

Published: May 27, 2024

Abstract Background Metritis is a prevalent uterine disease that affects the welfare, fertility, and survival of dairy cows. The microbiome from cows develop metritis those remain healthy do not differ calving until 2 days postpartum, after which there dysbiosis characterized by shift towards opportunistic pathogens such as Fusobacteriota Bacteroidota. Whether these proliferate overtake commensals could be determined type substrates present in uterus. objective this study was to integrate metabolome data advance understanding environment metritis. Holstein ( n = 104) had fluid collected at day diagnosis. Cows with 52) were paired without based on calving. First, evaluated individually, then integrated using network analyses. Results did but differed diagnosis between both Omics integration performed 6 significant bacteria genera 153 metabolites Integration because no differences microbiome. A total 3 (i.e. Fusobacterium, Porphyromonas , Bacteroides ) strongly correlated 49 Seven among pathogenic main have been associated attenuation biofilm formation commensal bacteria, overgrowth, tissue damage inflammation, immune evasion, dysregulation. Conclusions presented herein helps identified may provide competitive advantage promising targets for future interventions aiming reduce growth

Language: Английский

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Lactobacillomics as a new notion in lactic acid bacteria research through omics integration

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Feb. 1, 2025

Abstract Omics technologies are a set of disciplines that analyze large-scale molecular data to understand biological systems in holistic way. These aim reveal the structure, functions and interactions organisms by studying processes at many levels biomolecules, from genome metabolism. Lactobacillomics is introduced as an interdisciplinary field integrates multiple “omics” technologies—including genomics, transcriptomics, proteomics, metabolomics, metagenomics— provide comprehensive insight into “lactic acid bacteria” species. aims elucidate genetic, metabolic, functional characteristics lactic bacteria (LAB) species, providing insights mechanisms underlying their probiotic effects contributions host microbiome. By analyzing genomes metabolic pathways, researchers can identify specific genes responsible for health-promoting desirable fermentation characteristics, which guide development targeted strains with optimized health benefits. The integration these omics allows facilitating discovery biomarkers disease states, new probiotics tailored populations or conditions, optimization enhance safety, flavor, nutritional profile fermented foods. A review bibliometric analysis were conducted overview this promising between 2005 2025 examining Web Science Core Collection data. Research results trending topics, future perspectives, key areas growth within studies, particularly they intersect technologies.

Language: Английский

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Bifidobacterium longum Ameliorates Intestinal Inflammation and Metabolic Biomarkers in Mice Fed a High-Fat Diet with Gliadin by Indoleacrylic Acid

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

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