Use of an Antibacterial Mouthwash Alters the Gut Microbiome, Reduces Nutrient Absorption and Attenuates Diet-induced Obesity DOI Creative Commons
Mattias Carlström, Lucas P. Carvalho, Ariela Maína Boeder

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 8, 2023

Abstract Prolonged use of antibacterial mouthwash is linked to increased risk systemic disease. We aimed investigate if disturbing the oral microbiota would impact lower gut microbiome with functional effects in diet-induced obesity. Mice were exposed chlorhexidine and fed a Western diet. Food intake weight gain monitored, metabolic function, blood pressure analyzed. Chlorhexidine reduced bacteria altered parts known be associated pathways. gain, body fat, steatosis, plasma insulin without changing caloric intake, while increasing colon triglycerides proteins demonstrating absorption these nutrients. The mechanisms behind as well link between small intestinal function need pinpointed. While short-term this model appear beneficial, potential long-term disruptions possible malabsorption should considered.

Language: Английский

Cardiovascular disease and risk in COPD: a state of the art review DOI Creative Commons

Ricardo Polman,

John R. Hurst, Ömer Uysal

et al.

Expert Review of Cardiovascular Therapy, Journal Year: 2024, Volume and Issue: 22(4-5), P. 177 - 191

Published: March 26, 2024

Chronic Obstructive Pulmonary Disease (COPD) and cardiovascular diseases (CVD) commonly co-exist. Outcomes of people living with both conditions are poor in terms symptom burden, receiving evidence-based treatment mortality. Increased understanding the underlying mechanisms may help to identify treatments relieve this disease burden. This narrative review covers overlap COPD CVD a focus on clinical presentation, mechanisms, interventions. Literature up December 2023 cited.

Language: Английский

Citations

17
Unlocking the gut-heart axis: exploring the role of gut microbiota in cardiovascular health and disease DOI Open Access

Sanobar Shariff,

Alicia Kwan Su Huey, Nishant Parag Soni

et al.

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 86(5), P. 2752 - 2758

Published: Jan. 17, 2024

Gut microbiota has emerged as a pivotal player in cardiovascular health and disease, extending its influence beyond the gut through intricate metabolic processes interactions with immune system. Accumulating evidence supports significant association between diseases such atherosclerosis, hypertension, heart failure. Dietary patterns have been identified key factors shaping composition of exerting notable impacts on health. Probiotics prebiotics shown promise mitigating risks disease by modulating parameters. Faecal transplantation (FMT) recently novel intriguing therapeutic strategy.

Language: Английский

Citations

12
Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway DOI Creative Commons
Qing-Yun Hao,

Jing Yan,

Jintao Wei

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 10, 2024

Emerging evidence indicates that alteration of gut microbiota plays an important role in chronic kidney disease (CKD)-related vascular calcification (VC). We aimed to investigate the specific and underlying mechanism involved CKD-VC. identified increased abundance Prevotella copri (P. copri) feces CKD rats (induced by using 5/6 nephrectomy followed a high calcium phosphate diet) with aortic via amplicon sequencing 16S rRNA genes. In patients CKD, we further confirmed positive correlation between P. scores. Moreover, oral administration live aggravated CKD-related VC osteogenic differentiation smooth muscle cells vivo, accompanied intestinal destruction, enhanced expression Toll-like receptor-4 (TLR4), elevated lipopolysaccharide (LPS) levels. vitro ex vivo experiments consistently demonstrated copri-derived LPS (Pc-LPS) accelerated phosphate-induced VSMC differentiation. Mechanistically, Pc-LPS bound TLR4, then activated nuclear factor κB (NF-κB) nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome signals during VC. Inhibition NF-κB reduced NLRP3 attenuated Pc-LPS-induced calcification. Our study clarifies novel VC, mechanisms involving inflammation-regulating metabolites including Pc-LPS, activation NF-κB/NLRP3 signaling pathway. These findings highlight its-derived as potential therapeutic targets for CKD.

Language: Английский

Citations

12
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL DOI
Yi Wang, Guo‐Chong Chen, Zheng Wang

et al.

Circulation, Journal Year: 2024, Volume and Issue: 150(3), P. 215 - 229

Published: June 19, 2024

Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, blood metabolites among US Hispanic Latino adults.

Language: Английский

Citations

7
Association of short-chain fatty acids and the gut microbiome with type 2 diabetes: Evidence from the Henan Rural Cohort DOI
Tianyu Yang,

Cuiping Wu,

Yuqian Li

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Language: Английский

Citations

4
Roadmap for alleviating the manifestations of ageing in the cardiovascular system DOI
Luca Liberale, Simon Tual‐Chalot, Simon Sedej

et al.

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Deciphering the tripartite interaction of urbanized environment, gut microbiome and cardio-metabolic disease DOI

Avaneesh Shukla,

Chanchal Sharma, Md. Zubbair Malik

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 377, P. 124693 - 124693

Published: Feb. 28, 2025

Language: Английский

Citations

0
Investigating the gut bacteria structure and function of hibernating bats through 16S rRNA high-throughput sequencing and culturomics DOI Creative Commons
Limei Shen, Ying Liu, Tao Gu

et al.

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

ABSTRACT The gut microbiota of bats is vital for their roles in health and the ecosystem, yet studies on hibernating southwest China, particularly unique karst landscape Guizhou, are limited. We captured three bat species—Pipistrellus (PB), Rhinolophus (RB), Myotis (MB)—in Liping County, collecting rectal samples 16S rRNA amplicon sequencing. Data processing involved Trimmomatic, Flash, Qiime2 operational taxonomic unit (OTU) standardization species annotation via Greengenes database. Differential abundance was analyzed using LEfSe, diversity metrics were assessed through alpha beta analyses. RB group predominantly composed Proteobacteria (80.99%), while MB PB exhibited diverse compositions with significant OTU richness (729 MB). Notable genera included Hafnia Yersinia Cosenzaea myxofaciens MB. High proportions unclassified taxa observed, (83.81%). Functional predictions indicated metabolic pathways, a representation human diseases PB. Culturomics revealed successful cultivation Huaxiibacter chinensis Enterobacter chengduensis from first time appears to have identified new bacterium that likely closely related Clostridium paraputrificum . IMPORTANCE Our research reveals differences composition among groups (PB, MB, RB) Guizhou. While predominates all groups, its varies. Notably, high units (OTUs) suggests more microbial underscoring complex interactions between diversity, diet, microbiota, overall ecological dynamics bats. Furthermore, substantial presence unknown bacterial intestines highlights critical importance cultivation-based approaches. specific may potential implications both humans. These findings emphasize need further investigations into functional these contributions host health. Future should focus longitudinal elucidate intricate interactions.

Language: Английский

Citations

0
Toxic metals impact gut microbiota and metabolic risk in five African-origin populations DOI Creative Commons
Julianne Jorgensen, Candice Choo-Kang, Luyu Wang

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: 2(1), P. 1 - 15

Published: April 9, 2025

Language: Английский

Citations

0
Lactobacillus Restructures the Micro/Mycobiome to Combat Inflammation-Mediated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension DOI
Sasha Z. Prisco, Madelyn Blake, Felipe Kazmirczak

et al.

Circulation Heart Failure, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

BACKGROUND: Inflammation suppresses right ventricular (RV) function in pulmonary arterial hypertension (PAH). In particular, we showed GP130 (glycoprotein-130) signaling promotes pathological microtubule remodeling and RV dysfunction rodent PAH. Emerging data demonstrate the intestinal microbiome regulates systemic inflammation, but impact of modulating gut on GP130-microtubule axis failure is unknown. METHODS: Two weeks following monocrotaline injection, rats were administered daily Lactobacillus rhamnosus (4×10 7 colony-forming units) via oral gavage for 10 days. Next-generation metagenomics internal transcribed spacer 2 sequencing delineated fecal bacterial fungal compositions. SomaScan proteomics measured levels 7596 serum proteins. immunoblots quantified protein abundances. Light or super resolution confocal microscopy assessed RV, lung, jejunal morphology. Echocardiography invasive closed-chest pressure-volume loops evaluated PAH severity function. The relationship between abundance was 65 patients with RESULTS: administration restructured both micro- mycobiome. alteration ecosystem improved health as demonstrated by increased villus length glycocalyx thickness diminished permeability biomarkers. Serum revealed modulated inflammation decreased circulating ligands. -mediated suppression blunted cardiomyocytes. Microtubule-associated phenotypes, including cardiomyocyte nuclear hypertrophy, transverse tubule integrity, connexin-43 localization, all corrected . These cellular changes manifested despite no significant severity. Finally, detectable had superior similar mean pressure vascular resistance compared those without CONCLUSIONS: supplementation restructures micro/mycobiome, restores health, dampens reduces ligands associated remodeling. identify a novel microbiome-inflammation-microtubule that has therapeutic relevance dysfunction.

Language: Английский

Citations

0