Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(46), P. 17819 - 17832
Published: Oct. 31, 2023
The
immunomodulatory
potential
of
certain
bacterial
strains
suggests
that
they
could
be
beneficial
in
the
treatment
rheumatoid
arthritis
(RA).
In
this
study,
we
investigated
effects
Bifidobacterium
longum
subsp.
infantis
B6MNI
on
progression
collagen-induced
(CIA)
rats
as
well
its
influence
gut
microbiota
and
fecal
metabolites.
Forty-eight
female
Wistar
were
divided
into
six
groups
included
a
group
with
CIA
intragastrically
administered
B.
(109
CFU/day/rat),
control
(CON),
group,
both
which
intracardiacally
same
volume
saline.
Rats
sacrificed
after
short-term
(ST,
4
weeks)
or
long-term
(LT,
6
administration.
results
indicate
can
modulate
metabolites,
including
5-hydroxyindole-3-acetic
acid
(5-HIAA),
turn
impacts
expression
Pim-1
immune
cell
differentiation,
then
through
JAK-STAT3
pathway
affects
joint
inflammation,
regulates
osteoclast
differentiation
factors,
delays
RA.
Our
also
suggest
is
most
efficacious
for
early
middle
stages
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(24), P. 5112 - 5112
Published: Dec. 14, 2023
As
a
medicinal
and
edible
plant,
Chinese
yam
(CY)
can
promote
the
enrichment
of
intestinal
probiotics.
Mucilage
polysaccharides,
diosgenin
taxifolin
are
dominant
components
CY.
The
purpose
this
study
was
to
investigate
whether
impact
on
gut
microbiome
structure
metabolism
is
attributable
its
components.
In
in
vitro
gastrointestinal
digestion
colon
fermentation
system,
changes
microbiota
composition
function
were
determined
by
16S
rRNA
sequencing,
levels
bacterial
metabolites
including
short-chain
fatty
acids
(SCFAs)
indole-like
detected
gas
chromatography
an
enzyme-linked
immunoassay.
results
show
that
CY,
mucilage
could
increase
microbial
diversity
index.
Furthermore,
probiotics
Lactobacillus
Bacteroides
significantly
increased,
while
harmful
bacteria
such
as
Escherichia
Proteus
declined.
CY
production
SCFAs
acetic
acid
butyric
acid.
Of
note,
displayed
similar
impacts
enhancing
abundance
Clostridium
promoting
indole-3-lactic
lactic
These
findings
provide
evidence
supporting
natural
food
regulate
health.
Diosgenin
component
contributes
mostly
regulating
flora.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(15), P. 8749 - 8759
Published: April 5, 2024
The
precise
impact
of
species
and
strain
diversity
on
fungal–bacterial
interactions
the
overall
community
functioning
has
remained
unclear.
First,
our
study
revealed
how
Debaryomyces
hansenii
influences
diverse
bacteria
to
accumulate
key
metabolites
in
a
simulated
fermented
food
system.
For
flavor,
D.
promoted
accumulation
branched-chain
esters
Staphylococcus
xylosus
by
promoting
growth
facilitating
precursor
acids
transformations
but
hindered
equorum.
Furthermore,
displayed
among
S.
equorum
strains.
bioactive
compounds,
lactic
acid
(LAB)
also
production
indole
derivatives.
Then,
we
investigated
specific
metabolic
exchanges
under
reciprocal
interaction.
Amino
acids,
rather
than
vitamins,
were
identified
as
primary
drivers
bacterial
promotion.
Moreover,
played
significant
role
production.
Finally,
synthetic
capable
producing
high
concentrations
derivatives
was
successfully
constructed.
These
results
provide
valuable
insights
into
understanding
designing
communities
for
sausages.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 30, 2024
Abstract
Background
Metritis
is
a
prevalent
uterine
disease
that
affects
the
welfare,
fertility,
and
survival
of
dairy
cows.
The
microbiome
from
cows
develop
metritis
those
remain
healthy
do
not
differ
calving
until
2
days
postpartum,
after
which
there
dysbiosis
characterized
by
shift
towards
opportunistic
pathogens
such
as
Fusobacteriota
Bacteroidota.
Whether
these
proliferate
overtake
commensals
could
be
determined
type
substrates
present
in
uterus.
objective
this
study
was
to
integrate
metabolome
data
advance
understanding
environment
metritis.
Holstein
(n
=
104)
had
fluid
collected
at
day
diagnosis.
Cows
with
52)
were
paired
without
based
on
calving.
First,
evaluated
individually,
then
integrated
using
network
analyses.
Results
did
but
differed
diagnosis
between
both
Omics
integration
performed
6
significant
bacteria
genera
153
metabolites
Integration
because
no
differences
microbiome.
A
total
3
(i.e.
Fusobacterium,
Porphyromonas
,
Bacteroides
)
strongly
correlated
49
Seven
among
pathogenic
main
have
been
associated
attenuation
biofilm
formation
commensal
bacteria,
overgrowth,
tissue
damage
inflammation,
immune
evasion,
dysregulation.
Conclusions
presented
herein
helps
identified
may
provide
competitive
advantage
promising
targets
for
future
interventions
aiming
reduce
growth
Molecular Omics,
Journal Year:
2023,
Volume and Issue:
20(1), P. 19 - 26
Published: Aug. 31, 2023
Lactic
acid
is
a
versatile,
multi-functional
organic
monomer
in
various
industries,
creating
worldwide
demand.
High
titer
lactic
production
was
achieved
by
novel
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(46), P. 17819 - 17832
Published: Oct. 31, 2023
The
immunomodulatory
potential
of
certain
bacterial
strains
suggests
that
they
could
be
beneficial
in
the
treatment
rheumatoid
arthritis
(RA).
In
this
study,
we
investigated
effects
Bifidobacterium
longum
subsp.
infantis
B6MNI
on
progression
collagen-induced
(CIA)
rats
as
well
its
influence
gut
microbiota
and
fecal
metabolites.
Forty-eight
female
Wistar
were
divided
into
six
groups
included
a
group
with
CIA
intragastrically
administered
B.
(109
CFU/day/rat),
control
(CON),
group,
both
which
intracardiacally
same
volume
saline.
Rats
sacrificed
after
short-term
(ST,
4
weeks)
or
long-term
(LT,
6
administration.
results
indicate
can
modulate
metabolites,
including
5-hydroxyindole-3-acetic
acid
(5-HIAA),
turn
impacts
expression
Pim-1
immune
cell
differentiation,
then
through
JAK-STAT3
pathway
affects
joint
inflammation,
regulates
osteoclast
differentiation
factors,
delays
RA.
Our
also
suggest
is
most
efficacious
for
early
middle
stages
