Current Opinion in Infectious Diseases,
Journal Year:
2023,
Volume and Issue:
36(6), P. 427 - 435
Published: Sept. 21, 2023
Purpose
of
review
Mucormycosis
(MCR)
is
a
common
opportunistic
mold
infection,
and
Mucorales
were
recently
designated
by
WHO
as
priority
pathogens.
The
interest
in
this
infection
has
risen
significantly
since
the
major
outbreak
MCR
context
COVID-19
pandemic,
particularly
India.
Herein,
we
summarize
(last
24
months)
published
information
regarding
clinical
aspects
MCR.
Recent
findings
disease
remains
protean
its
presentation,
difficult
to
diagnose,
challenging
treat.
In
2021,
cases
COVID-19-associated
mucormycosis
(CAM)
exploded
India
during
manifested
primarily
sino-orbital
or
sino-cerebral
disease.
Its
classic
risk
factors
included
triad
COVID-19,
uncontrolled
diabetes
mellitus
use
corticosteroids.
Despite
difficulties
timely
diagnosis
MCR,
significant
progress
been
made
with
molecular
techniques
blood
assist
earlier
diagnosis,
which
can
facilitate
appropriate
therapy
improve
outcomes.
addition,
advances
have
imaging
stage
disease,
determining
what
types
multimodal
are
required
depending
on
staging,
tissue-based
identification
Mucorales.
Summary
Although
outlook
for
improved,
effective
new
antifungals,
stratification,
optimal
multimodality
approaches
remain
an
unmet
need.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(1), P. 85 - 85
Published: Jan. 22, 2024
Mucormycosis
presents
a
formidable
challenge
to
clinicians
and
researchers.
Animal
models
are
an
essential
part
of
the
effort
decipher
pathogenesis
mucormycosis
develop
novel
pharmacotherapeutics
against
it.
Diverse
model
systems
have
been
established,
using
range
animal
hosts,
immune
metabolic
perturbations,
infection
routes.
An
understanding
characteristics,
strengths,
drawbacks
these
is
needed
optimize
their
use
for
specific
research
aims.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(3), P. 554 - 554
Published: March 11, 2024
Over
60%
of
emerging
infectious
diseases
in
humans
are
zoonotic,
often
originating
from
wild
animals.
This
long-standing
ecological
phenomenon
has
accelerated
due
to
human-induced
environmental
changes.
Recent
data
show
a
significant
increase
fungal
infections,
with
6.5
million
cases
annually
leading
3.7
deaths,
indicating
their
growing
impact
on
global
health.
Despite
the
vast
diversity
species,
only
few
known
infect
and
marine
mammals.
Fungal
zoonoses,
especially
those
involving
mammals
like
cetaceans,
public
health
concern.
Increased
human–cetacean
interactions,
both
professional
recreational
settings,
pose
risks
for
zoonotic
disease
transmission.
review
focuses
epidemiology,
clinical
manifestations,
potential
major
pathogens
shared
highlighting
interspecies
transmission
capability
challenges
posed
by
antifungal
resistance
It
underscores
need
enhanced
awareness
preventative
measures
high-risk
settings
protect
ecosystems.
