Biomedical Engineering Letters, Journal Year: 2023, Volume and Issue: 14(2), P. 245 - 254
Published: Dec. 4, 2023
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 8, 2024
Abstract Bioelectronic implantable devices are adept at facilitating continuous monitoring of health and enabling the early detection diseases, offering insights into physiological conditions various bodily organs. Furthermore, these advanced systems have therapeutic capabilities in neuromodulation, demonstrating their efficacy addressing diverse medical through precise delivery stimuli directly to specific targets. This comprehensive review explores developments applications bioelectronic within biomedical field. Special emphasis is placed on evolution closed‐loop systems, which stand out for dynamic treatment adjustments based real‐time feedback. The integration Artificial Intelligence (AI) edge computing technologies discussed, significantly bolster diagnostic functions devices. By elemental analyses, current challenges, future directions devices, aims guide pathway advances
Language: Английский
Citations
14
Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(7)
Published: March 16, 2024
Abstract Electroceuticals derived from electronic and pharmaceuticals is a term coined to describe the therapeutic manipulation of neuronal signaling. In recent years, complexity range applications electroceuticals have grown considerably. Therefore, here revised ontology framework for defining that broadens concept beyond neuron‐targeted interventions suggested. This more inclusive aims provide greater coherence bring together different stakeholders accelerate progress in this field. It suggested can be categorized according level physiology which they act: cellular, tissue, organ, systemic. Emerging developments each category future directions are discussed pharmaceutical industry perspective. Potential challenges highlighted translation electroceuticals, such as lack clinical biomarkers incomplete understanding mechanisms action offer solutions stimulating exciting
Language: Английский
Citations
6
Comprehensive physiology, Journal Year: 2022, Volume and Issue: unknown, P. 3989 - 4037
Published: Aug. 11, 2022
We review the structure and function of vagus nerve, drawing on information obtained in humans experimental animals. The nerve is largest longest cranial supplying structures neck, thorax, abdomen. It also only which vast majority its innervation territory resides outside head. While belonging to parasympathetic division autonomic nervous system, primarily sensory—it dominated by sensory axons. discuss macroscopic microscopic features including a detailed description extensive territory. Histochemical genetic profiles afferent efferent axons are detailed, as central nuclei involved processing conveyed generation motor (including parasympathetic) outflow via nerve. provide comprehensive physiological roles vagal neurons control cardiovascular, respiratory, gastrointestinal systems, finish with discussion interactions between immune system. © 2022 American Physiological Society. Compr Physiol 12: 3989–4037, 2022.
Language: Английский
Citations
26
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(5), P. 1717 - 1717
Published: Feb. 21, 2023
Despite the vagus nerve stimulator (VNS) being used in neuroscience, it has recently been highlighted that cardioprotective functions. However, many studies related to VNS are not mechanistic nature. This systematic review aims focus on role of therapy, selective stimulators (sVNS), and their functional capabilities. A systemic current literature was conducted VNS, sVNS, ability induce positive effects arrhythmias, cardiac arrest, myocardial ischemia/reperfusion injury, heart failure. Both experimental clinical were reviewed assessed separately. Of 522 research articles retrieved from archives, 35 met inclusion criteria included review. Literature analysis proves combining fiber-type selectivity with spatially-targeted stimulation is feasible. The as a tool for modulating dynamics, inflammatory response, structural cellular components prominently seen across literature. application transcutaneous opposed implanted electrodes, provides best outcome minimal side effects. presents method future cardiovascular treatment can modulate human physiology. continued needed further insight.
Language: Английский
Citations
11
iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109137 - 109137
Published: Feb. 6, 2024
Cardiovagal neurons (CVNs) innervate cardiac ganglia through the vagus nerve to control function. Although cardioinhibitory role of CVNs in nucleus ambiguus (CVN
Language: Английский
Citations
4
Heart Failure Reviews, Journal Year: 2024, Volume and Issue: 29(6), P. 1201 - 1215
Published: Aug. 9, 2024
Abstract Increased sympathetic and reduced parasympathetic nerve activity is associated with disease progression poor outcomes in patients chronic heart failure. The demonstration that markers of autonomic imbalance vagal dysfunction, such as rate variability baroreflex sensitivity, hold prognostic value failure despite modern therapies encourages the research for neuromodulation strategies targeting vagus nerve. However, approaches tested so far have yielded inconclusive results. This review aims to summarize current knowledge about role nervous system failure, describing pathophysiological background, methods assessment, rationale, limits, future perspectives stimulation either by drugs or bioelectronic devices.
Language: Английский
Citations
4
Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 42, P. 100859 - 100859
Published: Sept. 17, 2024
Language: Английский
Citations
4
Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
Neuromodulation comes into focus as a non-pharmacological therapy with the vagus nerve modulation target. The auricular stimulation (aVNS) has emerged to treat chronic diseases while re-establishing sympathovagal balance and activating parasympathetic anti-inflammatory pathways. aVNS leads still over under-stimulation is limited in therapeutic efficiency. A potential avenue personalization of based on time-varying cardiorespiratory rhythms human body. In pilot study, we propose personalized cardiac-gated evaluate its effects instantaneous beat-to-beat intervals (RR intervals). Modulation RR expected reveal efficiency since efferent cardiac branch stimulated afferent governs RR. Five healthy subjects were subjected aVNS. Each subject underwent two 25-min sessions. first session started non-gated open-loop aVNS, followed by systole-gated closed-loop then non-gated, diastole-gated, each for 5min. second session, systole diastole gated interchanged. Changes are analysed comparing prolongation respect proceeding interval where took place. These changes considered function onset, angle starting R peak. influence respiration phases cardiovagal modulation. results show that tends prolong shorten when after before peak, respectively. later time onset within diastole-gated longer be subsequent interval. tendency raises increasing gradually levels off delay from one slope this rise larger than When considering individual phases, inspiratory seems largest values thus modulatory capacity time-gated This study indicates modulate heartbeat activity which attenuated diseases. highest during inspiration.
Language: Английский
Citations
0
Clinical Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 100335 - 100335
Published: April 1, 2025
Language: Английский
Citations
0
Bioelectronic Medicine, Journal Year: 2023, Volume and Issue: 9(1)
Published: April 27, 2023
Abstract In recent decades, vagus nerve stimulation (VNS) therapy has become widely used for clinical applications including epilepsy, depression, and enhancing the effects of rehabilitation. However, several questions remain regarding optimization this to maximize outcomes. Although parameters such as pulse width, amplitude, frequency are well studied, timing delivery both acutely (with respect disease events) chronically (over timeline a disease’s progression) generally received less attention. Leveraging information would provide framework implementation next generation closed-loop VNS therapies. mini-review, we summarize number therapies discuss (1) general considerations these (2) open that could lead further optimization.
Language: Английский
Citations
7