Essential Hypertension and Oxidative Stress: Novel Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 14489 - 14489

Published: Nov. 21, 2022

Among cardiovascular diseases, hypertension is one of the main risk factors predisposing to fatal complications. Oxidative stress and chronic inflammation have been identified as potentially responsible for development endothelial damage vascular stiffness, two primum movens diseases. Based on these data, we conducted an open-label randomized study, first, evaluate stiffness in hypertense patients; second, test effect supplementation with a physiological antioxidant (melatonin 1 mg/day year) patients essential vs. hypertensive controls. Twenty-three either gender were enrolled 1:1 groups (control supplemented group). The plasmatic total capacity (as marker oxidative stress), blood pressure, arterial peripheral function evaluated at beginning study after year both groups. Our results showed that improved significantly (p = 0.022) patients. increased too, even if not 0.688), melatonin administration. Moreover, group significative reduction TAC levels 0.041) correlated improvement stiffness. These data suggest may play important role reducing serum and, consequently, improving

Language: Английский

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Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3392 - 3392

Published: Feb. 8, 2023

Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce production, expanding social life around the clock. However, physiology behavior that evolved in context 24 h solar days are frequently perturbed by exposure to at night. This is particularly salient circadian rhythms, result endogenous biological clocks with a rhythm ~24 h. Circadian rhythms govern features behavior, set precisely primarily during day, though other factors, such as timing meals, can also affect rhythms. significantly affected night shift work because nocturnal light, electronic devices, shifts meals. Night workers increased risk for metabolic disorder, well several types cancer. Others who exposed or late mealtimes show disrupted cardiac disorders. It imperative understand how alter function develop strategies mitigate their negative effects. In this review, we provide an introduction physiological regulation homeostasis suprachiasmatic nucleus (SCN), SCN-mediated hormones display including melatonin glucocorticoids. Next, discuss circadian-gated processes sleep food intake, followed modern lighting disrupts molecular clock Lastly, identify disruptions metabolism increase susceptibility syndrome cardiovascular diseases, various harmful consequences associated on health.

Language: Английский

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Coffee drinking timing and mortality in US adults

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Background and Aims To identify the patterns of coffee drinking timing in US population evaluate their associations with all-cause cause-specific mortality. Methods This study included 40 725 adults from National Health Nutrition Examination Survey 1999–2018 who had complete information on dietary data 1463 Women’s Men’s Lifestyle Validation Study 7-day record. Clustering analysis was used to timing. Results In this observational study, two distinct [morning type (36% participants) all-day-type (14% participants)] were identified validated Study. During a median (interquartile range) follow-up 9.8 (9.1) years, total 4295 deaths, 1268 cardiovascular disease 934 cancer deaths recorded. After adjustment for caffeinated decaffeinated intake amounts, sleep hours, other confounders, morning-type pattern, rather than significantly associated lower risks (hazard ratio: .84; 95% confidential interval: .74–.95) disease-specific .69; .55–.87) mortality as compared non-coffee drinking. Coffee modified association between amounts (P-interaction = .031); higher risk participants pattern but not those pattern. Conclusions Drinking morning may be more strongly later day.

Language: Английский

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Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 9, 2023

Abstract Combined chemotherapy is a treatment method based on the simultaneous use of two or more therapeutic agents; it frequently necessary to produce effective for cancer patients. Such combined treatments often improve outcomes over that monotherapy approach, as drugs synergistically target critical cell signaling pathways work independently at different oncostatic sites. A better prognosis has been reported in patients treated with combination therapy than single drug chemotherapy. In recent decades, 5-fluorouracil (5-FU) become one most widely used agents treatment. This medication, which soluble water, first line anti-neoplastic agent several types including breast, head and neck, stomach colon cancer. Within last three many studies have investigated melatonin an anti-cancer agent; this molecule exhibits various functions controlling behavior cells, such inhibiting growth, inducing apoptosis, invasion. The aim review comprehensively evaluate role complementary 5-FU-based cancers. Additionally, we identify potential common by 5-FU interact enhance efficacy therapy. Graphic abstract

Language: Английский

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Melatonin: Facts, Extrapolations and Clinical Trials

Biomolecules, Journal Year: 2023, Volume and Issue: 13(6), P. 943 - 943

Published: June 5, 2023

Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, focus changed from investigating natural role as transducer biological time for physiological systems to hypothesized roles virtually all clinical conditions. This goes along with appearance extensive literature claiming (generally) positive benefits high doses melatonin animal models and various situations would not be receptor-mediated. Based on assumption safe, have been administered patients, including elderly children, trials. this review, we critically review corresponding literature, hypotheses acts scavenger molecule, particular mitochondria, by trying only contextualize these interests but also attempting separate wheat chaff (or wishful thinking facts). We conclude most claims remain experimental evidence used promote them limited sometimes flawed. Our will hopefully encourage researchers reflect what can cannot do help move field forward solid basis.

Language: Английский

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Dietary Supplements Potentially Target Plasma Glutathione Levels to Improve Cardiometabolic Health in Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 944 - 944

Published: Feb. 14, 2023

Cardiovascular diseases (CVDs) continue to be the leading cause of death in people with diabetes mellitus. Severely suppressed intracellular antioxidant defenses, including low plasma glutathione (GSH) levels, are consistently linked pathological features such as oxidative stress and inflammation. In fact, it has already been established that GSH levels associated increased risk CVD diabetes. Dietary supplements widely used may offer therapeutic benefits for at an developing CVDs. However, information remains thoroughly scrutinized. Hence, current systematic review explored prominent search engines, PubMed Google Scholar, updated literature from randomized clinical trials reporting on effects dietary Available evidence indicates supplements, coenzyme Q10, selenium, curcumin, omega-3 fatty acids, vitamin E or D, potentially improve cardiometabolic health patients Such beneficial related enhancing reducing cholesterol, biomarkers available is very limited additional studies still required validate these findings, resolving issues bioavailability bioactive compounds.

Language: Английский

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A Systematic Review on Advances in Management of Oxidative Stress-Associated Cardiovascular Diseases

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 923 - 923

Published: July 29, 2024

Oxidative stress plays a significant role in the pathogenesis of cardiovascular diseases, such as myocardial ischemia/reperfusion injury, atherosclerosis, heart failure, and hypertension. This systematic review aims to integrate most relevant studies on oxidative management diseases. We searched literatures PubMed database using specific keywords. put emphasis those manuscripts that were published more recently higher impact journals. reviewed total 200 articles. examined current managements including supplements like resveratrol, vitamins C E, omega-3 fatty acids, flavonoids, coenzyme-10, which have shown antioxidative properties potential benefits. In addition, we pharmacological treatments newly discovered antioxidants nanoparticles show effects targeting pathways. Lastly, biomarkers, soluble transferrin receptor, transthyretin, cystatin evaluating antioxidant status identifying risk. By addressing mechanisms, this paper emphasizes importance maintaining balance between oxidants progression is registered with International Platform Registered Systematic Review Meta-analysis Protocols (INPLASY), registration # INPLASY202470064.

Language: Английский

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Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Life, Journal Year: 2024, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 5, 2024

Cardiovascular disease is the cause of physical infirmity and thousands deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms energy production metabolic processing. Additionally, inflammation accumulation non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces initiation progression atherosclerotic lesions, which are often basis coronary artery disease. The current review critically analyzes published data related experimental use melatonin forestall pathologies. Collectively, these studies document melatonin’s anti-atherosclerotic actions reducing LDL oxidation triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, proliferation invasion arterial smooth muscle cells into lesioned area, restricting ingrowth blood vessels from vasa vasorum, solidifying plaque cap reduce chance its rupture. Diabetic hyperglycemia, aggravates also inhibited by supplementation animals. potential value non-toxic as a possible inhibitor pathology humans should be seriously considered performing clinical trials using this multifunctional molecule.

Language: Английский

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Gut microbially produced tryptophan metabolite melatonin ameliorates osteoporosis via modulating SCFA and TMAO metabolism

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(3)

Published: April 1, 2024

Abstract Osteoporosis (OP) is a severe global health issue that has significant implications for productivity and human lifespan. Gut microbiota dysbiosis been demonstrated to be closely associated with OP progression. Melatonin (MLT) an important endogenous hormone modulates bone metabolism, maintains homeostasis, improves Multiple studies indicated MLT participates in the regulation of intestinal gut barrier function. However, promising effects microbiota‐derived remain unclear. Here, we found resulted tryptophan disorder decreased production MLT, while administration could mitigate OP‐related clinical symptoms reverse dysbiosis, including diversity microbiota, relative abundance many probiotics such as Allobaculum Parasutterella , metabolic function flora amino acid nucleotide energy metabolism. Notably, significantly increased short‐chain fatty acids trimethylamine N‐oxide‐related metabolites. Importantly, modulate dynamic balance M1/M2 macrophages, reduce serum levels pro‐inflammatory cytokines, restore gut‐barrier Taken together, our results highlighted roles microbially derived progression via “gut‐bone” axis SCFA which may provide novel insight into development drug treating OP.

Language: Английский

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Melatonin and Risk of Age-Related Macular Degeneration

JAMA Ophthalmology, Journal Year: 2024, Volume and Issue: 142(7), P. 648 - 648

Published: June 6, 2024

Importance Melatonin has been shown to oppose several processes that are known mediate age-related macular degeneration (AMD), but whether melatonin can confer benefits against AMD remains unclear. Objective To examine the association between supplementation and risk of development or progression AMD. Design, Setting, Participants This retrospective cohort study accessed data from TriNetX, a national database deidentified electronic medical records both inpatient outpatient health care organizations across US, December 4, 2023, March 19, 2024. Patients aged 50 years older, 60 70 older with no history (AMD-naive group) nonexudative (nonexudative were queried for instances medication codes November 14, 2008, 2023. then classified into either group control based on presence melatonin. Propensity score matching (PSM) was performed match cohorts demographic variables, comorbidities, nonmelatonin hypnotic use. Exposure The at least 4 each occurred 3 months apart. Main Outcomes Measures After PSM, compared evaluate ratios (RRs) 95% CIs having an outcome. For AMD-naive group, outcome defined as new diagnosis any AMD, whereas exudative Results Among 121 523 patients in melatonin-naive (4848 [4580 after PSM; mean (SD) age, 68.24 (11.47) years; 2588 female (56.5%)] 116 675 68.17 (10.63) 2681 (58.5%)]), use associated reduced developing (RR, 0.42; CI, 0.28-0.62). 66 253 (4350 [4064 80.21 (8.78) 2482 (61.1%)] 61 903 80.31 (8.03) 2531 (62.3%)]), 0.44; 0.34-0.56). results consistent among subsets individuals cohort: RR, 0.36 [95% 0.25-0.54]; 0.38 0.30-0.49]) 0.35 0.23-0.53]; 0.40 0.31-0.51]). Conclusions Relevance decreased Although lifestyle factors may have influenced this association, these findings provide rationale further research efficacy using preventive therapy

Language: Английский

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