Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(1), P. 92 - 92
Published: Jan. 10, 2024
The
search
for
alternatives
to
cisplatin
has
led
the
development
of
new
metal
complexes
where
thiazoline
derivatives
based
on
platinum(II)
and
palladium(II)
stand
out.
In
this
sense,
Pt(II)
Pd(II)
coordinated
with
derivative
ligand
2-(3,4-dichlorophenyl)imino-N-(2-thiazolin-2-yl)thiazolidine
(TdTn),
formula
[PtCl2(TdTn)]
[PdCl2(TdTn)],
have
previously
shown
good
results
against
several
cancer
lines;
however,
in
work,
we
managed
improve
their
activity
by
supporting
them
mesoporous
silica
nanoparticles
(MSN).
incorporation
compounds
a
melatonin
(5-methoxytryptamine,
5MT),
which
is
well-known
antioxidant
apoptosis
inducer
different
types
cancer,
been
able
increase
cytotoxic
both
MSN-supported
isolated
only
very
low
amount
(0.35%
w/w)
antioxidant.
covalently
functionalized
systems
that
synthesized
are
selectivity
as
well
accumulation
HeLa
cells.
final
materials
containing
5MT
(MSN-5MT-PtTdTn
MSN-5MT-PdTdTn)
required
up
nine
times
less
achieve
same
than
corresponding
non-formulated
counterparts
did,
thus
reducing
potential
side
effects
caused
use
free
complexes.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115464 - 115464
Published: Sept. 15, 2023
Luteolin
is
a
flavonoid
widely
present
in
various
traditional
Chinese
medicines.
In
recent
years,
luteolin
has
received
more
attention
due
to
its
impressive
liver
protective
effect,
such
as
metabolic
associated
fatty
disease,
hepatic
fibrosis
and
hepatoma.
This
article
summarizes
the
pharmacological
effects,
pharmacokinetic
characteristics,
toxicity
of
against
diseases,
provides
prospect.
The
results
indicate
that
improves
lesions
through
mechanisms,
including
inhibiting
inflammatory
factors,
reducing
oxidative
stress,
regulating
lipid
balance,
slowing
down
excessive
aggregation
extracellular
matrix,
inducing
apoptosis
autophagy
cancer
cells.
Pharmacokinetics
research
manifested
bioavailability
relatively
low.
It
worth
noting
appropriate
modification,
new
delivery
systems,
derivatives
can
enhance
bioavailability.
Although
many
studies
have
shown
minimal,
strict
experiments
are
still
needed
evaluate
safety
promote
reasonable
development.
addition,
this
study
also
discussed
clinical
applications
related
luteolin,
indicating
it
key
component
commonly
used
drugs
practice.
view
excellent
expected
become
potential
drug
for
treatment
diseases.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 12, 2024
Breast
cancer
is
one
of
the
most
common
female
malignant
tumors
today
and
represents
a
serious
health
risk
for
women.
Although
survival
rate
quality
life
patients
with
breast
are
improving
continuous
development
medical
technology,
metastasis,
recurrence,
drug
resistance
remain
significant
problem.
Huaier,
traditional
Chinese
medicine
(TCM)
fungus,
type
Sophora
embolism
fungus
growing
on
old
stems.
The
polysaccharides
Trametes
robiniophila
Murr
(PS-T)
main
active
ingredient
Huaier.
There
increasing
evidence
that
Huaier
has
great
potential
in
treatment,
its
anti-cancer
mechanism
may
be
related
to
variety
biological
activities,
such
as
inhibition
cell
proliferation,
tumor
angiogenesis,
promotion
death,
regulation
tumor-specific
immunity.
effective
clinical
treatment
cancer.
This
review
systematically
summarizes
basic
studies
use
cancer,
providing
useful
information
guide
application
future
studies.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Numerous
research
works
have
emphasized
the
critical
role
that
circadian
rhythm
plays
in
tumor
microenvironment
(TME).
The
goal
of
clarifying
chrono-pharmacological
strategies
for
improving
cancer
treatment
clinical
settings
is
a
continuous
endeavor.
Consequently,
to
enhance
use
time-based
pharmaceutical
therapies
oncology,
combining
existing
knowledge
on
rhythms'
roles
within
TME
essential.
This
perspective
elucidates
functions
rhythms
across
various
stages
development,
progression,
and
metastasis.
Specifically,
aging,
angiogenesis,
inflammation
are
implicated
modulating
TME.
Furthermore,
exerts
profound
influence
current
treatments
thereby
generates
chronotheray
manage
tumors.
From
perspective,
offers
promising
opportunities
prevention
treatment;
nevertheless,
further
study
needed
address
unanswered
scientific
problems.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5888 - 5888
Published: May 28, 2024
Cyclodextrins
(CDs)
are
cyclic
oligosaccharides
able
to
form
noncovalent
water-soluble
complexes
useful
in
many
different
applications
for
the
solubilization,
delivery,
and
greater
bioavailability
of
hydrophobic
drugs.
The
complexation
5-fluorouracil
(5-FU)
with
natural
or
synthetic
cyclodextrins
permits
solubilization
this
poorly
soluble
anticancer
drug.
In
theoretical
work,
between
β-CD
5-FU
investigated
using
molecular
mechanics
(MM)
dynamics
(MD)
simulations
water.
inclusion
formed
thanks
favorable
intermolecular
interactions
5-FU.
Both
1:1
1:2
β-CD/5-FU
stoichiometries
investigated,
providing
insight
into
their
interaction
geometries
stability
over
time
complexes,
affect
drug's
mobility,
suggesting
a
two-step
release
mechanism:
fast
more
exposed
hydrated
drug
molecule,
freedom
movement
near
rims,
slow
one
less-hydrated
well-encapsulated
confined
MD
study
drugs
specific
carriers
at
atomistic
level,
possible
mechanism
highlighting
role
impact
concentration
on
kinetics
process
A
comparison
experimental
data
literature
provides
further
insights.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(3), P. 356 - 356
Published: March 16, 2024
In
all
mammals,
the
circulating
pool
of
MLTs
is
synthesized
in
pineal
gland
during
night’s
darkness
hours.
Its
main
function
synchronizing
organism
photoperiod.
contrast,
extra-pineal
MLT
peripheral
organs,
does
not
follow
any
circadian
rhythm
or
circulate,
and
plays
a
detoxifying
cytoprotective
role.
Circulating
may
stimulate
both
innate
acquired
immune
responses
through
its
action
by
activating
high-affinity
receptors
on
immunocompetent
cells.
Extra-pineal
have
antioxidant
anti-inflammatory
effects
that
dampen
response.
These
two
seemingly
divergent
roles
be
considered
to
sides
same
coin.
fact,
integration
functions
might
generate
balanced
effective
response
against
microbial
pathogens.
The
studies
described
this
review
investigated
exogenous
various
models
infectious
diseases
using
extremely
different
doses
treatment
schedules.
None
them
evaluated
possibility
integrating
non-circadian
effect
with
immunoenhancing
MLT.
As
consequence,
spite
fact
most
agree
has
beneficial
infections,
it
seems
difficult
draw
definite
conclusion
about
possible
therapeutic
use.
