Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(3), P. 1128 - 1128

Published: Jan. 31, 2023

Background and aim: Chronic low-grade inflammation is associated with various health outcomes, including cardiovascular diseases (CVDs) cancers. Systemic immune index (SII) system response (SIRI) have lately been explored as novel prognostic markers for all-cause mortality mortality. However, studies on prediction value in nationwide representative population are scarce, which limit their generalization. To bridge the knowledge gap, this study aims to prospectively assess association of SII, SIRI National Health Nutrition Examination Survey (NHANES). Methods: From 1999 2018, 42,875 adults who were free pregnancy, CVDs (stroke, acute coronary syndrome), cancers, had follow-up records participated NHANES included study. SII quantified by calculating composite indicators from blood routine. explore characteristics different or levels, we divided them according quartile SIRI. The associations between SIRI, events examined using a Cox regression model. investigate whether there was reliable relationship these two indices mortalities, performed subgroup analysis based sex age. Results: A total eligible individuals enrolled, mean age 44 ± 18 years old. During period up 20 years, 4250 deaths occurred, 998 CVDs. proportional hazards modeling showed that levels >655.56 higher (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.18–1.41) (HR, 1.33; CI, 1.11–1.59) than those <335.36. Adults >1.43 risk 1.39; 1.26–1.52) death 1.14–1.68) <0.68. In general older 60 elevation death. Conclusion: Two inflammatory indices, closely death, more attention should be paid systemic provide better preventive strategies.

Language: Английский

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Association of systemic immune inflammatory index with all-cause and cause-specific mortality in hypertensive individuals: Results from NHANES

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

The relationship between the systemic immune inflammatory index (SII) and prognosis of hypertensive patients is unclear. This study aims to explore association SII with all-cause cause-specific mortality in hypertension.This included 8524 adults hypertension from National Health Nutritional Examination Surveys (NHANES) 2011-2018, followed for survival through December 31, 2019. Cox proportional hazards models were used investigate associations all causes, cardiovascular disease (CVD), cancer. Restricted cubic spline, piecewise linear regression, subgroup sensitivity analyses also used.During a median follow-up 4.58 years, 872 deaths occurred. After adjusting covariates, higher was significantly associated an elevated risk CVD mortality. There 102% increased per one-unit increment natural log-transformed (lnSII) (P < 0.001). Consistent results observed when examined as categorical variable (quartiles). cancer detected U-shaped threshold values 5.97 6.18 lnSII respectively. Below thresholds, lower (HR=0.79, 95%CI=0.64-0.97) (HR=0.73, 95%CI=0.53-1.00). Above positive (HR=1.93, 95%CI=1.55-2.40) 95%CI=1.22-3.05). robust analyses.Higher (either continuous or variable)

Language: Английский

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Associations between systemic immune-inflammation index and abdominal aortic calcification: Results of a nationwide survey

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2023, Volume and Issue: 33(7), P. 1437 - 1443

Published: April 23, 2023

Language: Английский

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Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: An extensive literature review

Turkish Journal of Emergency Medicine, Journal Year: 2024, Volume and Issue: 24(1), P. 8 - 19

Published: Jan. 1, 2024

In the field of critical care medicine, substantial research efforts have focused on identifying high-risk patient groups. This has led to development diverse diagnostic tools, ranging from basic biomarkers complex indexes and predictive algorithms that integrate multiple methods. Given ever-evolving landscape driven by rapid advancements, changing treatment strategies, emerging diseases, validation tools remains an ongoing dynamic process. Specific changes in complete blood count components, such as neutrophils, lymphocytes, monocytes, platelets, are key immune system responses influenced various factors crucial systemic inflammation, injury, stress. It been reported indices neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), immune-inflammation index (SII), inflammation response (SIRI), delta neutrophil calculated using ratios these elements, important predictors outcomes conditions where inflammatory process is at forefront. this narrative review, we concluded NLR, PLR, SII, SIRI show promise predicting for different health related inflammation. While tests accessible, reliable, cost-effective, their standalone performance a specific condition limited.

Language: Английский

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Association between systemic immune-inflammation index and psoriasis: a population-based study

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 5, 2024

Background The systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood, is regarded as a favorable indicator of both inflammatory state immune response. Psoriasis an immune-mediated disease notable for its chronic inflammation the entire system. Our research sought to explore latent link between psoriasis SII. Methods We performed cross-sectional investigation utilizing data extracted from National Health Nutrition Examination Survey (NHANES, 2009-2014). Employing multivariate linear regression models subgroup analysis, we uncover association SII psoriasis. Results This study enrolled total 17,913 participants part cohort. analysis revealed positive correlation [1.013 (1.000, 1.026)]. As tertiles increased, risk demonstrated upward trend. significant dependence on this were maintained women, BMI(≥ 30 kg/m2),non-stroke non-cancer subjects interaction tests. Furthermore, identified psoriasis, characterized two consecutive inverted U-shaped patterns. Notably, most prominent inflection point at specific value 797.067. Conclusions results indicate elevated levels presence However, corroborate strengthen these results, additional large-scale prospective studies are required.

Language: Английский

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The Association Between Left Ventricular Global Function Index and Major Adverse Cardiovascular Events Linked to Systemic Inflammation in Acute Coronary Syndrome

Angiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We aimed to investigate the association between systemic inflammation and left ventricular global function index (LVGFI) evaluate diagnostic performance of LVGFI for MACEs across acute coronary syndrome (ACS) spectrum. A total 1697 patients (794 with ST-segment elevation myocardial infarction [STEMI] 903 non-STEMI [NSTEMI]) were evaluated. The was calculated using echocardiography. Inflammatory status assessed C-reactive protein (CRP) immune (SII). defined as non-fatal re-infarction, repeated revascularization target vessel, all-cause mortality at a 3-year follow-up. While STEMI group exhibited lower values compared NSTEMI ( P < .001), it had higher SII level .001) CRP = .021). quartiles levels more pronounced in group. threshold value predict <21.8% (Sensitivity 79.2%, Specificity 68.7%) STEMI, while <25.4% 77.4%, 70.8%) NSTEMI. Considering both inflammatory ACS spectrum when evaluating could provide comprehensive assessment cardiac prognosis patients.

Language: Английский

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Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 12

Published: Feb. 15, 2023

In the U.S. general population, there is a lack of understanding regarding association between systemic immune inflammation (SII) index and estimated pulse wave velocity (ePWV), atherogenic plasma (AIP), triglyceride-glucose (TyG) cardiovascular disease (CVD). As result, objective our research was to investigate SII ePWV, AIP, TyG incident CVD. We used National Health Nutrition Examination Survey (NHANES) data from 1999 2018 conduct this study. The correlation examined using generalized additive models with smooth functions. addition, triglyceride (TC), high-density lipoprotein cholesterol (HDL-C), fast glucose (FBG) also were explored. Finally, we further performed multivariable logistic regression analysis, restricted cubic spline (RCS) plots, subgroup analysis study connection Our included 17389 subjects NHANES database. A substantial positive existed SII, WV, index. increase index, AIP showed trend decreasing first, then rising, decreasing. inversely linearly associated (TG), while positively (FBG). However, (HDL-C) had tendency first declining, climbing, finally falling rise in After adjusting for potential confounders, compared lowest quartiles, odds ratios 95% confidence intervals CVD across quartiles 0.914 (0.777, 1.074), 0.935 (0.779, 1.096), 1.112 (0.956, 1.293) RCS plot an inverse U-shaped curve relationship Overall, found strong higher ePWV Additionally, these cross-sectional revealed

Language: Английский

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Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8414 - 8414

Published: May 8, 2023

Childhood obesity represents a worldwide concern as many countries have reported an increase in its incidence, with possible cardiovascular long-term implications. The mechanism that links disease to is related low-grade inflammation. We designed this study investigate the diagnostic utility of inflammatory indices (NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte SII, systemic immune-inflammation index; SIRI, inflammation response index) obese children metabolic syndrome (MetS) and their relationship cardiometabolic risk biomarkers, such Homeostasis Model Assessment Insulin Resistance (HOMA-IR), triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C), non-high-density (non-HDL-C). A total 191 from one large Romanian reference center was included study. Patients were classified two groups according presence (MetS group) or absence (non-MetS syndrome. According our results, SII index proved value distinguishing MetS patients among (AUC = 0.843, sensitivity 0.83, specificity 0.63). Furthermore, positively associated biomarkers (HOMA-IR, p < 0.001; TG:HDL-C, 0.002; non-HDL-C, 0.021), highlighting role additional measure instability children.

Language: Английский

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Systemic immune-inflammation index (SII) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in the general population

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Dec. 9, 2023

Abstract Background An elevated systemic immune-inflammation index (SII) is associated with higher mortality in patients coronary artery disease and other diseases. However, the potential of SII for predicting general population has been underexplored. Therefore, this study aimed to analyze relationship between all-cause, cardiovascular disease, cardiocerebrovascular population. Methods This involved 26,855 participants (≥ 18 years) from National Health Nutrition Examination Survey 1999–2014 who were grouped according tertiles. Survival differences groups analyzed using log-rank tests Kaplan–Meier plots. Furthermore, multivariate Cox regression restricted cubic spline analyses used examine cardiovascular, cardio-cerebrovascular mortality. Results Overall, 1947 (7.425%) died following an average follow-up 87.99 ± 54.04 months. Among these, 325 (1.210%) deaths related diseases 392 (1.459%) analysis revealed statistically significant cerebrovascular tertiles (log-rank test: all P < 0.001). Multi-adjusted models showed that highest tertile had a risk death all-cause (hazard ratio [HR] = 1.48, 95% confidence interval [CI] 1.48–1.48) (HR 1.60, CI 1.60–1.61) compared those lowest tertile. In addition, curve indicated nonlinear association (P 0.001), threshold value at 18.284. There was 15% decrease each twofold change on left flank 0.85, 0.69–1.05) 42% increase 1.42, 1.23–1.64) right inflection point. increased nonlinearly by 39% per 1.39, 1.07–1.81). also 1.29, 1.00–1.66). Conclusions population, significantly mortality, regardless established factors.

Language: Английский

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The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia

Biomolecules, Journal Year: 2023, Volume and Issue: 13(2), P. 297 - 297

Published: Feb. 4, 2023

Neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte (PLR), monocyte–lymphocyte (MLR) and systemic immune-inflammation index (SII index) are increasingly used as indicators of inflammation in different conditions, including schizophrenia. However, their relationship with negative symptoms, anhedonia, is largely unknown. Included were 200 patients schizophrenia 134 healthy controls (HC), assessed for physical anhedonia (PA), using the Revised Physical Anhedonia Scale (RPAS), social (SA) by Social (RSAS). Patients rated Positive Negative Syndrome (PANSS), Clinical Assessment Interview Symptoms (CAINS) Brief Symptom (BNSS). Most symptoms a weak to moderate positive correlations blood cell inflammatory ratios, namely, between NLR MLR PANSS scale, CAINS, BNSS, male patients, PLR scale CAINS. Fewer detected females, but also direction. An exception was SA, given correlation its severity SII presence higher males. While associated subclinical inflammation, SA lower markers deserves further exploration.

Language: Английский

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