Association of the systemic immune-inflammation index with anemia: a population-based study DOI Creative Commons
Shuying Chen,

Jigang Xiao,

Wenyu Cai

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Background Inflammation has been reported to be related anemia. As a novel inflammatory marker, Systemic immune-inflammation index (SII) not studied with Anemia. The aim of this study was investigate the possible relationship between SII and Methods This retrospective cross-sectional survey conducted using data from 2005–2018 National Health Nutrition Examination Survey (NHANES) population. In total, 19851 American adults aged ≥18 years were included. calculated as platelet count×neutrophil count/lymphocyte count. Anemia defined hemoglobin (Hgb) levels < 13 g/dL in males 12 females. Logistic regression analyses, subgroup analyses sensitivity performed Results Our included total patients, which 1501 (7.6%) had After adjusting for all covariates, multivariate logistic analysis showed that higher (In-transform) level associated increased likelihood anemia (OR=1.51, 95% CI: 1.36–1.68, P<0.001). association exhibited nonlinear manner. positive correlation severity Subgroup there no significant dependence on age, family income, body mass index, hypertension, kidney disease cancer except gender association. Furthermore, confirmed robustness our results. Conclusion demonstrated positively especially among female participants. And Further large-scale prospective studies are still needed analyze role

Language: Английский

Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis DOI Creative Commons
Arduino A. Mangoni, Angelo Zinellu

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 21, 2023

Introduction An excessive systemic pro-inflammatory state increases the risk of severe disease and mortality in patients with coronavirus 2019 (COVID-19). However, there is uncertainty regarding whether specific biomarkers inflammation can enhance stratification this group. We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from routine hematological parameters, index (SII), COVID-19 different severity survival status. Methods A literature search was PubMed, Web Science, Scopus, between 1 st December 15 th March 2023. Risk bias certainty evidence were assessed using Joanna Briggs Institute Critical Appraisal Checklist Grades Recommendation, Assessment, Development Evaluation, respectively (PROSPERO registration number: CRD42023420517). Results In 39 studies, or non-survivor status had significantly higher SII values on admission compared non-severe survivor (standard mean difference (SMD)=0.91, 95% CI 0.75 1.06, p<0.001; moderate evidence). The also associated death 10 studies reporting odds ratios (1.007, 1.001 1.014, p=0.032; very low evidence) six hazard (1.99, 1.01 3.92, p=0.047; Pooled sensitivity, specificity, area under curve for 0.71 (95% 0.67 0.75), 0.64 0.77), 0.77 0.73 0.80), respectively. meta-regression, significant correlations observed SMD albumin, lactate dehydrogenase, creatinine, D-dimer. Discussion Our has shown that COVID-19. Therefore, inflammatory haematological parameters be helpful early Systematic https://www.crd.york.ac.uk/PROSPERO , identifier CRD42023420517.

Language: Английский

Citations

23
The association between systemic inflammation markers and the prevalence of hypertension DOI Creative Commons

Nake Jin,

Lei Huang,

Jun Hong

et al.

BMC Cardiovascular Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 14, 2023

Abstract Background We conducted a large-scale epidemiological analysis to investigate the associations between systemic inflammation markers and hypertension prevalence. Our aim is identify potential biomarkers for early detection of hypertension. Methods A cross-sectional study with 119664 individuals from National Health Nutrition Examination Survey was performed. investigated three markers, namely immune index (SII), system response (SIRI), aggregate (AISI), prevalence Results The rates gradually increased increasing logSII, logSIRI, logAISI quartiles. In continuous analyses, each unit increase in associated 20.3%, 20.1%, 23.7% risk Compared those lowest quartiles, risks subjects highest quartiles were 1.114-fold,1.143-fold, 1.186-fold. restricted cubic splines (RCS) revealed non-linear relationship elevation Specifically, per standard deviation any these variables respective 9%, 16%, 11% Conclusion reveals significant positive correlations SII, SIRI, AISI

Language: Английский

Citations

23
Association between inflammatory biomarkers and mortality in individuals with type 2 diabetes: NHANES 2005–2018 DOI
Jiaqi Zhang, Xiaoting Fan, Yan Xu

et al.

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 209, P. 111575 - 111575

Published: Feb. 11, 2024

Language: Английский

Citations

12
The neutrophil-to-lymphocyte ratio is associated with coronary heart disease risk in adults: A population-based study DOI Creative Commons
Yu Wang,

Yangping Zhuang,

Changsha Lin

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(2), P. e0296838 - e0296838

Published: Feb. 13, 2024

The purpose of this study was to look at any connections that could exist between neutrophil-lymphocyte ratio and coronary heart disease. We performed a cross-sectional research 13732 participants in the National Health Nutrition Examination Survey who were 40 or older. Multivariate logistic regression models investigated relationship neutrophil-to-lymphocyte levels disease risk. To investigate potential nonlinear connections, smoothed curve fitting used. When discovered, inflexion point determined using recursive method. After controlling for relevant confounders, independently linked higher risk (OR = 1.74, 95% CI:1.30–2.33, P 0.0002). Subgroup analyses showed statistically significant positive associations women 1.25, CI:1.09–1.43), 60 years age older 1.09, CI:1.00–1.19), smoking status every day not all 1.23, CI:1.00–1.52; OR alcohol use moderate 1.11, CI:1.00–1.22), body mass index >30 kg/m 2 1.42, CI:1.10–1.82), hypertensive CI:1.02–1.22), individuals without diabetes 1.17, CI:1.06–1.31). A correlation also seen by smoothing fitting, with an 1.08 ( <0.05). Our shows elevated are

Language: Английский

Citations

11
The diagnostic role of the systemic inflammation index in patients with immunological diseases: a systematic review and meta-analysis DOI Creative Commons
Arduino A. Mangoni, Angelo Zinellu

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 29, 2024

Abstract The identification of novel, easily measurable biomarkers inflammation might enhance the diagnosis and management immunological diseases (IDs). We conducted a systematic review meta-analysis to investigate an emerging biomarker derived from full blood count, systemic index (SII), in patients with IDs healthy controls. searched Scopus, PubMed, Web Science inception 12 December 2023 for relevant articles evaluated risk bias certainty evidence using Joanna Briggs Checklist Grades Recommendation, Assessment, Development, Evaluation Working Group system, respectively. In 16 eligible studies, had significantly higher SII when compared controls (standard mean difference, SMD = 1.08, 95% CI 0.75 1.41, p < 0.001; I 2 96.2%, moderate evidence). pooled area under curve (AUC) diagnostic accuracy was 0.85 (95% 0.82–0.88). subgroup analysis, effect size significant across different types ID, barring lupus erythematosus ( 0.20). further analyses, ID active disease vs. those remission (SMD 0.81, 0.34–1.27, 93.6%, AUC 0.74 0.70–0.78). Our study suggests that can effectively discriminate between subjects without disease. Prospective studies are warranted determine whether routine practice. (PROSPERO registration number: CRD42023493142).

Language: Английский

Citations

10
Systemic-inflammatory indices and clinical outcomes in patients with anterior circulation acute ischemic stroke undergoing successful endovascular thrombectomy DOI Creative Commons
Wenbo Cao, Yiming Song, Xuesong Bai

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31122 - e31122

Published: May 1, 2024

BackgroundThere is a lack of comprehensive profile assessment on complete blood count (CBC)-derived systemic-inflammatory indices, and their correlations with clinical outcome in patients anterior circulation acute ischemic stroke (AIS) who achieved successful recanalization by endovascular thrombectomy (EVT).MethodsPatients AIS caused large vessel occlusion (AIS-LVO) were retrospectively screened from December 2018 to 2022. Systemic-inflammatory indices including ratios neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), platelet-to-neutrophil (PNR), systemic immune-inflammation index (SII), inflammation response (SIRI), aggregate (AISI) admission the first day post-EVT calculated. Their symptomatic intracranial hemorrhage (sICH) unfavorable 90-day functional (modified Rankin Scale score 3-6) analyzed.ResultsA total 482 [65 (IQR, 56-72) years; 33% female] enrolled, which 231 (47.9%) had 50 (10.4%) developed sICH. Day 1 neutrophil monocyte counts, NLR, MLR, PLR, SII, SIRI, AISI increased, while lymphocyte PNR decreased compared levels. In multivariate analyses, count, independently associated outcome. Moreover, PNR, SIRI linked occurrence No variables identified as independent risk factors for patient outcomes.ConclusionCBC-derived measured after EVT are predictive sICH AIS-LVO.

Language: Английский

Citations

9
Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis DOI Creative Commons

Siye Xie,

Qi Wu

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 28, 2024

Sarcopenia is associated with increased morbidity and mortality. The systemic immune-inflammation index (SII) has been correlated to a variety of disorders. present study conducted systematic review meta-analysis investigate the relationship between SII sarcopenia.

Language: Английский

Citations

9
Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study DOI Creative Commons
Donghao Lu, Unnur Valdimarsdóttir, Dang Wei

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(31), P. 2865 - 2875

Published: June 18, 2024

Abstract Background and Aims Increasing evidence suggests that some reproductive factors/hazards are associated with a future risk of cardiovascular disease (CVD) in women. While major (non-perinatal) depression has consistently been CVD, the long-term CVD after perinatal (PND) is largely unknown. Methods A nationwide population-based matched cohort study involving 55 539 women diagnosed PND during 2001–14 Sweden 545 567 unaffected individually on age year conception/delivery was conducted. All were followed up to 2020. Perinatal identified from Swedish national health registers. Using multivariable Cox models, hazard ratios (HR) any type-specific according estimated. Results The mean at diagnosis 30.8 [standard deviation (SD) 5.6] years. During follow-up 20 years (mean 10.4, SD 3.6), 3533 (6.4%) (expected number 2077) 202 (3.7%) developed CVD. Compared women, had 36% higher developing [adjusted HR = 1.36, 95% confidence interval (CI): 1.31–1.42], while compared their sisters, 20% (adjusted 1.20, CI 1.07–1.34). results most pronounced without history psychiatric disorder (P for interaction &lt; .001). association observed all subtypes, highest case hypertensive (HR 1.50, CI: 1.41–1.60), ischaemic heart 1.37, 1.13–1.65), failure 1.06–1.74). Conclusions Women middle adulthood. Reproductive history, including PND, should be considered assessments

Language: Английский

Citations

9
Nonlinear association of the systemic immune-inflammatory index with mortality in diabetic patients DOI Creative Commons

Chunli Meng,

Kai Liu

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 13, 2024

Background It has been demonstrated that in diabetic patients, an elevated neutrophil-lymphocyte ratio (NLR) is independently connected with higher cardiovascular and all-cause mortality. unclear, however, if the systemic immune-inflammatory index (SII) mortality rate among patients are related. Investigating linkage between SII diabetes patients’ risk of death was aim study. Methods 4972 diabetics who were chosen from six rounds National Health Nutrition Examination Survey (NHANES) 2005 2016 study’s participants. The optimal threshold highest correlation survival outcomes identified by applying Maximum Selection Ranking Statistical Method (MSRSM). To assess relationship diabetics, subgroup analysis Cox regression modeling employed. Furthermore, smoothed curve fitting utilized to determine nonlinear them. Results Over course a median follow-up 69 months (interquartile range [IQR], 54-123 months), 1,172 (23.6%) 4,972 passed away. These deaths included 332 (6.7%) 840 (16.9%) non-cardiovascular deaths. Individuals categorized into (&gt;983.5714) lower (≤983.5714) groups according MSRSM. In multi-variable adjusted models, subjects had significantly increased chance dying disease (HR 2.05; 95% confidence interval (CI):1.42,2.97) all causes 1.60; CI:1.22,1.99). Kplan-Meier curves showed similar results. Subgroup studies based on age, sex, BMI, drinking, smoking, hypertension revealed connection maintained intact. previously stated variables did not interact (p interaction &gt; 0.05). smooth Conclusion linked

Language: Английский

Citations

8
Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators DOI Creative Commons
Lin Liu, Yanbo Zhao, Zeneng Cheng

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 29, 2025

Language: Английский

Citations

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