High-Density Lipoproteins at the Interface between the NLRP3 Inflammasome and Myocardial Infarction

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1290 - 1290

Published: Jan. 20, 2024

Despite significant therapeutic advancements, morbidity and mortality following myocardial infarction (MI) remain unacceptably high. This clinical challenge is primarily attributed to two factors: delayed reperfusion the injury resulting from coronary reperfusion. Following reperfusion, there a rapid intracellular pH shift, disruption of ionic balance, heightened oxidative stress, increased activity proteolytic enzymes, initiation inflammatory responses, activation several cell death pathways, encompassing apoptosis, necroptosis, pyroptosis. The or pyroptosis encompasses multiprotein complex known as NLRP3 inflammasome. High-density lipoproteins (HDL) are endogenous particles whose components can either promote mitigate In this comprehensive review, we explore role inflammasome in context MI provide detailed analysis how HDL modulate process.

Language: Английский

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Cardio-Protective-Promoting Properties of Functional Foods Inducing HDL-Cholesterol Levels and Functionality

Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(4), P. 469 - 502

Published: Sept. 30, 2024

High-density lipoprotein (HDL) has been proposed to provide cardio-protective properties through the functionality of its anti-inflammatory and antioxidant enzymatic machinery. Within this article, beneficial effects several functional foods on HDL levels for cardio-protection are thoroughly reviewed. Emphasis is given their health-promoting cardiovascular system benefits HDL, which act either solely or synergistically as an adjuvant approach with well-established anti-atherogenic therapies. Promising outcomes from both in vitro vivo studies animal models clinical trials, outline such functionality, discussed. The mechanisms obtained antioxidant, anti-inflammatory, antithrombotic, activities containing natural bioactives also outlined. Limitations future perspectives overall that these bioactive compounds exert important ingredients induce HDL-related strengthen health

Language: Английский

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Dantrolene is an HDL-associated paraoxonase-1 activator with immunosuppressive and atheroprotective properties

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Journal Year: 2025, Volume and Issue: 1870(2), P. 159596 - 159596

Published: Jan. 21, 2025

Language: Английский

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Tetranectin and Paraoxonase 1 in Patients with Varying Stages of Heart Failure: A Cross-Sectional Analysis

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(5), P. 86 - 86

Published: April 25, 2025

Background: Heart failure (HF) is a leading cause of mortality across the globe, prompting ongoing research into novel biomarkers for improved risk stratification and patient management. Methods: This cross-sectional study aimed to investigate relationship between two promising biomarkers, tetranectin paraoxonase 1, severity heart in cohort 87 patients with cardiovascular factors. Participants were categorized three groups based on their New York Association (NYHA) classification: no HF (Control), NYHA class I (G1), II-IV (G2). Results: Our analysis revealed stepwise decrease both TETRA PON1 levels increasing severity, Control group exhibiting highest G2 lowest. Interestingly, significant positive correlation was observed only group, suggesting potential interplay these healthy individuals that may be disrupted onset HF. Furthermore, positively associated left ventricular ejection fraction (LVEF) negatively diastolic dysfunction, indicating involvement systolic cardiac function. Conclusions: These findings suggest serve as valuable assessing prognosis. Further warranted validate larger, prospective studies explore clinical utility guiding treatment decisions.

Language: Английский

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The impact of alpha lipoic acid administration on oxidative stress markers and occurrence of no-reflow phenomenon in post myocardial infarction patients

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 6, 2025

Abstract Background Primary percutaneous coronary intervention (PPCI) is the treatment of choice for ST-segment-elevation myocardial infarction (STEMI). Post-PCI induced-oxidative stress, a complication PCI, linked to no-reflow (NR) phenomenon and poor prognosis. A clinical trial involving 70 STEMI patients was conducted evaluate impact alpha lipoic acid (ALA), an antioxidant anti-inflammatory agent, on oxidative stress NR. The participants were randomized standard care (control group) or 600 mg IV infusion ALA pre/peri PPCI then orally once 28 days plus (ALA group). Outcomes included degree reperfusion by thrombolysis in (TIMI) flow blush grade (MBG), Aldehyde dehydrogenase 2 (ALDH2) Paroxonase 1 (PON-1) levels, also left ventricular ejection fraction (LVEF), major adverse cardiac events (MACE). Results TIMI grade-3 MBG significantly higher group versus controls (97.1% 62.9%, respectively, P = 0.001, 82.9%, 45.7%, 0.002). ALDH2 PON-1 levels post-PPCI at all-time points (24 h 7 days). exhibited better LVEF when compared controls. Conclusion supplementation decreased occurrence NR, reduced ischemia–reperfusion injury (IRI) post-PPCI, increased ALDH2, improved LVEF.

Language: Английский

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IgG Autoantibodies against β₂‐Glycoprotein I Complexed with a Lipid Ligand Derived from Oxidized Low‐Density Lipoprotein are Associated with Arterial Thrombosis in Antiphospholipid Syndrome

Journal of Immunology Research, Journal Year: 2003, Volume and Issue: 10(2-4), P. 203 - 211

Published: Jan. 1, 2003

We recently reported [J. Lipid Res. 42 (2001), 697; 43 (2002), 1486; 44 (2003), 716] that [beta2-glycoprotein I (beta2GPI) forms complexes with oxidized LDL (oxLDL) and autoantibodies against these are present in patients SLE antiphospholipid syndrome (APS). The relationship of beta2GPI/oxLDL IgG beta2GPI complexed oxLig-1 (an oxLDL-derived ligand) clinical manifestations APS was studied 150 patients. levels were similar to those without APS, but they significantly higher than healthy individuals. There no difference the complex among arterial, venous thrombosis, or pregnancy morbidity. anti-beta2GPI/oxLig-1 Further, antibody arterial thrombosis Thus, oxidation leads formation In contrast, generated only strongly associated thrombosis. These results suggest etiologically important development atherosclerosis APS.

Language: Английский

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An antioxidant probiotic reduces postprandial lipemia and oxidative stress

Open Life Sciences, Journal Year: 2010, Volume and Issue: 6(1), P. 32 - 40

Published: Nov. 15, 2010

Abstract Reducing postprandial oxidative stress (OxS), decreasing blood triglyceride level (TG) and improving lipoprotein status is likely to have a preventive impact on the development of cardiovascular disease (CVD). Previously we shown that antioxidant probiotic Lactobacillus fermentum ME-3 (DSM14241) characterized by antiatherogenic effects. This randomized double-blind placebo-controlled study evaluated influence kefir enriched with an antioxidative L. (LfKef) OxS, TG response status. 100 clinically healthy subjects were recruited into study. Blood parameters determined oxidized LDL, baseline diene conjugation in LDL (BDC-LDL), complex beta-2 glycoprotein (Beta2-GPI-oxLDL), paraoxonase (PON) activity, LDL-Chol, HDL-Chol TG. To evaluate general body OxS-load measured 8-isoprostanes (8-EPI) urine. Consumption LfKef significantly reduced BDC-LDL, Beta2-GPI-oxLDL, urinary caused significant increase PON activity. first evidence may positive effect both OxS as well

Language: Английский

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Pleiotropic functions and clinical importance of circulating HDL-PON1 complex

Advances in clinical chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 132 - 171

Published: Jan. 1, 2024

Language: Английский

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The importance of paraoxonase 1 activity in chronic kidney disease

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: July 10, 2024

Paraoxonase 1 (PON1) is one of the most significant antioxidative enzymes associated with high-density lipoprotein (HDL). It has been proved that involved in pathogenesis many diseases including chronic kidney disease (CKD). The association between PON1 and CKD seems to be mutual, such produces a decrease activity levels, while genetics may affect risk susceptibility CKD. Recent studies reveal serum observed non-dialyzed dialyzed patients as well renal transplant (RT) linked an increased vulnerability atherosclerosis. We intend summarize current literature concerning CKD, highlighting on main determinants activity, its oxidative stress, impact genetic polymorphism development, effect drugs nutritional state. Furthermore, evidence supporting implication reduced incident cardiovascular patients, also examined. appears despite lack standardization measurement, remains valuable biomarker for researchers through last decades, which contributes assessment antioxidant status having prognostic benefit adverse clinical outcomes at various stages etiologies disease.

Language: Английский

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The effect of dual antioxidant modification on oxidative stress resistance and anti-dysfunction of non-split HDL and recombinant HDL

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134632 - 134632

Published: Aug. 9, 2024

Language: Английский

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