BMSCs-laden mechanically reinforced bioactive sodium alginate composite hydrogel microspheres for minimally invasive bone repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121933 - 121933

Published: Feb. 8, 2024

Language: Английский

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Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 19, 2024

Osteoarthritis is the most prevalent age-related degenerative joint disease and a leading cause of pain disability in aged people. Its etiology multifaceted, involving factors such as biomechanics, pro-inflammatory mediators, genetics, metabolism. Beyond its evident impact on functionality erosion patients' quality life, OA exhibits symbiotic relationships with various systemic diseases, giving rise to complications. This review reveals OA's extensive impact, encompassing osteoporosis, sarcopenia, cardiovascular diabetes mellitus, neurological disorders, mental health, even cancer. Shared inflammatory processes, genetic factors, lifestyle elements link these conditions. Consequently, recognizing connections addressing them offers opportunities enhance patient care reduce burden associated emphasizing need for holistic approach managing

Language: Английский

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Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1207 - 1233

Published: Jan. 1, 2025

Osteoarthritis (OA) affects several joints but tends to be more prevalent in those that are weight-bearing, such as the knees, which most heavily loaded body. The incidence and disability rates of OA have continued increase seriously jeopardise quality life middle-aged older adults. However, is than just a wear tear disease; its aetiology complex, pathogenesis poorly understood. Metabolic syndrome (MetS) has emerged critical driver development. This condition contributes formation distinct phenotype, termed metabolic syndrome-associated osteoarthritis (MetS-OA),which differs from other metabolically related diseases by unique pathophysiological mechanisms clinical presentation. As key mediators MetS, adipokines leptin, lipocalin, resistin regulate inflammation bone metabolism through or synergistic signaling pathways. Their modulation inflammatory responses remodeling processes plays role progression OA. Due their central regulating remodeling, not only deepen our understanding MetS-OA also represent promising targets for novel therapeutic strategies could slow disease improve outcomes affected patients.

Language: Английский

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The Expression Level of SOX Family Transcription Factors’ mRNA as a Diagnostic Marker for Osteoarthritis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1176 - 1176

Published: Feb. 11, 2025

Background/Objectives: Osteoarthritis (OA) is the most common degenerative and chronic joint disease a leading cause of pain disability in adults worldwide. The SRY-related HMG box (SOX) family transcription factors (TFs) play crucial role during pathogenesis OA; however, their exact mechanisms remain unexplored. aim our study was to conduct bioinformatics analysis interactions SOX-5, SOX-9, SOX-11 with other proteins, as well OA pathogenesis. Methods:SOX5, SOX9, SOX11 mRNA expression levels articular cartilage subchondral bone synovium from knee patients were assessed using qPCR method. group consisted thirty-one (n = 31). Total RNA isolated affected unaffected area joint. Results: Our results revealed regulatory network between SOX-11, various proteins involved collective interactions, which are regulation extracellular matrix (ECM) organization, response stimulus, gene expression, inflammatory response, condensation, ossification chondrocytes. Higher SOX5, noted OA-affected compared control tissue (p 0.00015, p 0.0024 > 0.05, respectively, Mann–Whitney U-test). All studied genes demonstrated elevated stage 4 than those 3 0.05; Lower found 0.0003, 0.05 0.0007, Decreased SOX9 3; SOX5 higher Conclusions: research show that SOX TFs development OA, contributing formation pathological changes not only cartilage, but also synovial membrane. may serve potential molecular diagnostic biomarkers for detecting could indicate progression this disease; observations require further investigation.

Language: Английский

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High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects: In vitro and in vivo studies

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 177 - 189

Published: Oct. 11, 2023

Reconstruction of subarticular bone defects is an intractable challenge in orthopedics. The simultaneous repair cancellous defects, fractures, and cartilage damage ideal surgical outcome. 3D printed porous anatomical WE43 (magnesium with 4 wt% yttrium 3 rare earths) scaffolds have many advantages for repairing such including good biocompatibility, appropriate mechanical strength, customizable shape structure, biodegradability. In a previous investigation, we successfully enhanced the corrosion resistance samples via high temperature oxidation (HTO). present study, explored feasibility effectiveness HTO-treated accompanied by split fractures vitro vivo experiments. After HTO treatment, dense layer mainly composed Y2O3 Nd2O3 formed on surface scaffolds. addition, majority grains were equiaxed, average grain size 7.4 μm. Cell rabbit experiments confirmed non-cytotoxicity biocompatibility implantation inside their structures could be maintained more than 12 weeks without penetration 6 penetration. During postoperative follow-up period up to 48 weeks, radiographic examinations histological analysis revealed that abundant gradually regenerated along scaffold degradation, stable osseointegration between new residues. MRI images further demonstrated no evidence any obvious cartilage, ligaments, or menisci, confirming absence traumatic osteoarthritis. Moreover, finite element biomechanical tests verified was conducive uniform distribution. conclusion, applying exhibited favorable effects possessing great potential clinical application.

Language: Английский

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Mgp High‐Expressing MSCs Orchestrate the Osteoimmune Microenvironment of Collagen/Nanohydroxyapatite‐Mediated Bone Regeneration

Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)

Published: April 8, 2024

Abstract Activating autologous stem cells after the implantation of biomaterials is an important process to initiate bone regeneration. Although several studies have demonstrated mechanism biomaterial‐mediated regeneration, a comprehensive single‐cell level transcriptomic map revealing influence on regulating temporal and spatial expression patterns mesenchymal (MSCs) still lacking. Herein, osteoimmune microenvironment depicted around classical collagen/nanohydroxyapatite‐based repair materials via combining analysis RNA sequencing transcriptomics. A group functional MSCs with high matrix Gla protein ( Mgp ) identified, which may serve as pioneer subpopulation involved in repair. Remarkably, these high‐expressing hi MSCs) exhibit efficient osteogenic differentiation potential orchestrate implanted biomaterials, rewiring polarization osteoclastic macrophages through Mdk/Lrp1 ligand–receptor pair. The inhibition activates pro‐inflammatory programs osteoclastogenesis. Meanwhile, multiple immune‐cell subsets also close crosstalk between secreted phosphoprotein 1 (SPP1) signaling pathway. These cellular profiles interactions characterized this study can broaden understanding MSC subpopulations at early stage regeneration provide basis for materials‐designed strategies that target modulation.

Language: Английский

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Research progress in Alzheimer's disease and bone-brain axis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102341 - 102341

Published: May 15, 2024

Alzheimer's disease (AD) is the most common type of cognitive impairment. AD closely related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms epidemiology pathogenesis. Brain bone tissues can regulate each other different manners through bone-brain axis. This article reviews research progress relationship between axis mechanisms AD, therapy by targeting axis, order deepen understanding communication, promote early diagnosis explore new for patients. Keywords

Language: Английский

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Non-Alcoholic Fatty Liver Disease and Bone Tissue Metabolism: Current Findings and Future Perspectives

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8445 - 8445

Published: May 8, 2023

Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions worldwide. Moreover, the prevalence of this expected to increase rapidly in near future, aligning with rise obesity and aging population. The pathogenesis NAFLD considered be complex include interaction between genetic, metabolic, inflammatory, environmental factors. It now well documented that linked other conditions common insulin resistance, such as abnormal lipid levels, metabolic syndrome, type 2 diabetes mellitus. Additionally, it resistance may one main mechanisms determining disturbances both bone tissue metabolism skeletal muscles quality functions patients NAFLD. To date, association osteoporosis has been described several studies, though worth noting most them included postmenopausal women or elderly originated from Asia. However, taking into account health economic burdens NAFLD, increasing children adolescents worldwide, further investigation relationship osteopenia, sarcopenia including young middle-aged patients, great importance. In addition, will help justify active screening surveillance osteopenia review, we discuss various pathophysiological possible biologically molecules interplay metabolism.

Language: Английский

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Exploring the Role of Hormones and Cytokines in Osteoporosis Development

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1830 - 1830

Published: Aug. 12, 2024

The disease of osteoporosis is characterized by impaired bone structure and an increased risk fractures. There a significant impact cytokines hormones on homeostasis the diagnosis osteoporosis. As defined World Health Organization (WHO), as having mineral density (BMD) that 2.5 standard deviations (SD) or more below average for young healthy women (T score < −2.5 SD). Cytokines hormones, particularly in remodeling between osteoclasts osteoblasts, control differentiation activation cells through cytokine networks signaling pathways like nuclear factor kappa-B ligand (RANKL)/the receptor RANKL (RANK)/osteoprotegerin (OPG) axis, while estrogen, parathyroid testosterone, calcitonin influence play roles treatment This review aims to examine pathophysiology osteoporosis, evaluating current diagnostic methods, highlighting new technologies could help early detection

Language: Английский

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Biomarkers That Seem to Have the Greatest Impact on Promoting the Formation of Atherosclerotic Plaque in Current Scientific Research

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 9503 - 9522

Published: Aug. 29, 2024

Atherosclerosis is a chronic inflammatory disease that causes degenerative and productive changes in the arteries. The resulting atherosclerotic plaques restrict vessel lumen, causing blood flow disturbances. Plaques are formed mainly large- medium-sized arteries, usually at bends forks where there turbulence flow. Depending on their location, they can lead to various states such as myocardial infarction, stroke, renal failure, peripheral vascular diseases, or sudden cardiac death. In this work, we reviewed literature early detection of atherosclerosis markers application photodynamic therapy atherosclerosis-related diseases. Herein, described roles C-reactive protein, insulin, osteopontin, osteoprotegerin, copeptin, TGF-β cytokine family, amino acid homocysteine. Also, discuss role microelements iron, copper, zinc, Vitamin D promoting formation plaque. Dysregulation administered compounds associated with an increased risk atherosclerosis. Additionally, taking into account pathophysiology plaque formation, believe maintaining homeostasis range biomarkers mentioned article crucial for slowing down process development stability already formed.

Language: Английский

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