Emerging Role of Ferroptosis in Diabetic Kidney Disease: Molecular Mechanisms and Therapeutic Opportunities

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(9), P. 2678 - 2694

Published: Jan. 1, 2023

Diabetic kidney disease (DKD) is one of the most common and severe microvascular complications diabetes mellitus (DM), has become leading cause end-stage renal (ESRD) worldwide.Although exact pathogenic mechanism DKD still unclear, programmed cell death been demonstrated to participate in occurrence development diabetic injury, including ferroptosis.Ferroptosis, an iron-dependent form driven by lipid peroxidation, identified play a vital role therapeutic responses variety diseases, such as acute injury (AKI), carcinoma DKD.In past two years, ferroptosis well investigated patients animal models, but specific mechanisms effects have not fully revealed.Herein, we reviewed regulatory ferroptosis, summarized recent findings associated with involvement DKD, discussed potential promising target for treatment, thereby providing valuable reference basic study clinical therapy DKD.

Language: Английский

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Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12293 - 12293

Published: July 31, 2023

The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, Siberia, have been used since ancient times to alleviate stress, fatigue, mental physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, rosin, tyrosol glucoside salidroside, tyrosol, are responsible for the biological action R. rosea, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. extract formulations as alternative remedies enhance cognitive functions protect central nervous system heart during stress. Recent studies indicate that may be treat diabetes, cancer, a variety cardiovascular neurological disorders such Alzheimer's Parkinson's diseases. This paper reviews beneficial effects its key active components, their possible use treatment chronic represents an excellent natural remedy address situations involving decreased performance, fatigue sense weakness, particularly context Given significance mitochondria cellular energy metabolism vulnerability reactive oxygen species, future research should prioritize investigating potential main bioactive phenolic compounds on mitochondria, thus targeting supply countering oxidative stress-related effects.

Language: Английский

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Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 115, P. 109731 - 109731

Published: Jan. 20, 2023

Language: Английский

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Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(3), P. C724 - C741

Published: Jan. 15, 2024

This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing community composition structure of intestinal microbiota, 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor its therapeutic efficacy.

Language: Английский

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Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127667 - 127667

Published: March 1, 2024

Language: Английский

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Gut microbiota in health and disease: advances and future prospects

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

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Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 15, 2024

Abstract Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients energy the host, but also plays crucial role immune modulation balance. In this review, we explore pathways associated with impact on host metabolism. We subsequently summarize recent studies influence regulation by discuss potential mechanisms through which affects ferroptosis. Additionally, conduct bibliometric analysis relationship between context chronic kidney disease. This can provide new insights into current research status future microbiota.

Language: Английский

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Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: July 19, 2023

Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It unrelated to hypertension and coronary artery can lead insufficiency, failure even death. Currently, the pathogenesis of DC unclear, clinical intervention mainly symptomatic therapy lacks effective objectives. Iron overdose mediated cell death, also known as ferroptosis, widely present in physiological pathological processes diabetes DC. key trace element human body, regulating metabolism glucose lipids, oxidative stress inflammation, other biological processes. Excessive iron accumulation imbalance antioxidant system activate aggravate such excessive autophagy mitochondrial dysfunction, resulting chain reaction accelerating myocardial microvascular damage. In-depth understanding mechanisms ferroptosis cardiovascular vessels help improve management. Therefore, this review, we summarize relationship between DC, well potential targets, discuss analyze limitations future development prospects these targets.

Language: Английский

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Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review

Chinese Herbal Medicines, Journal Year: 2023, Volume and Issue: 16(1), P. 42 - 55

Published: Dec. 13, 2023

The mild-natured and bitter-flavored traditional Chinese medicines (MB-TCMs) are an important class of TCMs that have been widely used in clinical practice recognized as safe long-term treatments for chronic diseases. However, TCMs, the panorama pharmacological effects mechanisms MB-TCMs not systemically reviewed. Compelling studies shown gut microbiota can mediate therapeutic activity help to elucidate core principles TCM medicinal theory. In this systematic review, we found commonly participated modulation metabolic syndrome, intestinal inflammation, nervous system disease cardiovascular association with promoting growth beneficial bacteria Bacteroides, Akkermansia, Lactobacillus, Bifidobacterium, Roseburia well inhibiting proliferation harmful Helicobacter, Enterococcus, Desulfovibrio Escherichia-Shigella. These alterations, correspondingly, enhance generation protective metabolites, mainly including short-chain fatty acids (SCFAs), bile acid (BAs), 5-hydroxytryptamine (5-HT), indole gamma-aminobutyric (GABA), inhibit such proinflammatory factors trimethylamine oxide (TAMO) lipopolysaccharide (LPS), further exert multiplicative maintenance human health through several different signaling pathways. Altogether, present review has attempted comprehensively summarize relationship between by establishing TCMs-gut microbiota-metabolite-signaling pathway-diseases axis, which may provide new insight into study theories their applications.

Language: Английский

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Spotlight on iron overload and ferroptosis: Research progress in female infertility

Life Sciences, Journal Year: 2023, Volume and Issue: 340, P. 122370 - 122370

Published: Dec. 22, 2023

Language: Английский

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