Soybean hull polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed zebrafish

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141123 - 141123

Published: Feb. 1, 2025

Language: Английский

---

Salidroside can protect against ferroptosis in cardiomyocytes and may be related to the regulation of GGT1

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Indroduction Ferroptosis, an iron-dependent cell death mechanism driven by lipid peroxidation, represents a novel therapeutic target for myocardial injury. Salidroside (SAL), natural bioactive compound derived from Rhodiola rosea, exhibits cardioprotective effects through multi-target mechanisms with minimal adverse effects, yet its precise role in ferroptosis regulation remains unclear. Methods This study systematically investigated SAL’s anti-ferroptotic using vitro (RSL3-induced H9C2 cardiomyocytes) and vivo (DOX-induced injury mouse model) approaches. Results SAL treatment significantly enhanced cardiomyocyte viability attenuating ferroptotic hallmarks, including ROS accumulation, iron overload, mitochondrial dysfunction. Transcriptomic analysis revealed SAL-mediated modulation of DNA replication/repair, cycle regulation, protein autophosphorylation, drug ADME processes, glutathione metabolism—a critical pathway ferroptosis. Molecular docking identified γ-glutamyltransferase 1 (GGT1) as high-affinity target, linking metabolism homeostasis. In MI mice, downregulated GGT1 expression while restoring ferroptosis-related biomarkers: upregulating GPX4 reducing SLC7A11/LC3II levels. Mechanistically, suppresses dual GGT1: (1) enhancing synthesis via inhibition (2) potentiating GPX4-mediated antioxidant defense. Discussion These findings establish pivotal cardioprotection, providing mechanistic basis clinical application ferroptosis-associated cardiovascular diseases.

Language: Английский

---

Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N6-methyladenosine (m6A) mediated silencing of SLC7A11

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116816 - 116816

Published: Aug. 2, 2024

Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m

Language: Английский

---

The antibacterial potential and effects of Rhodiola sp. on gut microbiota

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: April 27, 2024

Abstract The challenge of antimicrobial resistance requires new solutions, and Rhodiola sp. is a promising candidate due to its rich medicinal history. This review focuses on sp., especially R. rosea , highlighting phytochemical constituents, such as salidroside, rosavins, other phenolics, their potential. We investigate the efficacy against various pathogenic bacteria, suggesting value in combating resistance. Additionally, compounds are being investigated both direct antimicrobials modifiers that increase antibiotics. extracts salidroside modulate gut microbiota, thereby affecting health physiological metabolic disorders. illustrates comprehensive therapeutic potential emphasize importance understanding complex interactions between phytochemicals, effects, effects microbiota well need for in-depth research. Further studies will be crucial development holistic treatment approaches. Finally, highlighted an important natural resource fight microbial pathogens antibiotic Research should continue further unravel pharmacological health-promoting thus address public challenge.

Language: Английский

---

Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2747 - 2747

Published: June 9, 2024

Currently, an estimated 537 million individuals are affected by type 2 diabetes mellitus (T2DM), the occurrence of which is invariably associated with complications. Glucose-lowering therapy remains main treatment for alleviating T2DM. However, conventional antidiabetic agents fraught numerous adverse effects, notably elevations in blood pressure and lipid levels. Recently, use traditional Chinese medicines (TCMs) their constituents has emerged as a preferred management strategy aimed at curtailing progression its complications fewer effects. Increasing evidence indicates that gut microbiome disturbances involved development T2DM This regulation depends on various metabolites produced microbes interactions host organs. TCMs’ interventions have demonstrated ability to modulate intestinal bacterial microbiota, thereby restoring homeostasis ameliorating metabolic disorders. review delves into alterations microbiota patients how TCMs regulates facilitating Additionally, we also discuss prospective avenues research natural products advance therapy.

Language: Английский

---

Natural compounds efficacy in complicated diabetes: A new twist impacting ferroptosis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115544 - 115544

Published: Oct. 9, 2023

Ferroptosis, as a way of cell death, participates in the body's normal physiological and pathological regulation. Recent studies have shown that ferroptosis may damage glucose-stimulated islets β Insulin secretion programmed death T2DM target organs are involved pathogenesis its complications. Targeting suppression with specific inhibitors provide new therapeutic opportunities for previously untreated organs. Current suggest natural bioactive compounds, which abundantly available drugs, foods, medicinal plants treatment organs, recently received significant attention their various biological activities minimal toxicity, many compounds appear to role regulation Therefore, this review summarized potential strategies treat complications, providing lead phytochemical molecular nuclei future drug research development intervene T2DM.

Language: Английский

---

Targeting the programmed cell death (PCD) signaling mechanism with natural substances for the treatment of diabetic cardiomyopathy (DCM)

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(12), P. 5495 - 5508

Published: Aug. 25, 2023

Abstract Diabetic cardiomyopathy (DCM) is one of the severe complications diabetes, characterized by structural and functional abnormalities in hearts diabetic patients without hypertension, coronary heart disease, or valvular disease. DCM can progress to failure, which a significant cause death patients, but currently, there no effective treatment available. Programmed cell (PCD) genetically regulated form that includes apoptosis, autophagy, necroptosis, ferroptosis, pyroptosis. PCD essential for tissue homeostasis normal development body. complex condition, cascade signaling have been observed its pathological process, suggesting targeting could be potential therapeutic strategy. Studies shown natural substances effectively modulate intervene DCM, their use safe. This review explores role different forms pathogenesis summarizes research with treat DCM. It serve as basis further drug provide new strategies patients.

Language: Английский

---

Interplay between gut microbiota and the master iron regulator, hepcidin, in the pathogenesis of liver fibrosis

Pathogens and Disease, Journal Year: 2024, Volume and Issue: 82

Published: Jan. 1, 2024

Abstract Introduction: There is a proven role for hepcidin and the composition of gut microbiota its derivatives in pathophysiology liver fibrosis. Area covered: This review focuses on literature search regarding effect regulating physiology. We presented mechanisms expression discussed possible interaction between regulation. Furthermore, we investigated importance gene biological processes bacterial interactions using bioinformatics analysis. Expert Opinion: One main features fibrosis iron accumulation hepatic cells, including hepatocytes. can induce an oxidative stress response, inflammation, activation stellate cells. Hepcidin crucial regulator by targeting ferroportin expressed hepatocytes, macrophages, enterocytes. Various stimuli, such as load inflammatory signals, control bidirectional relationship exists metabolic activity microbiota. explored potential to influence potentially manage fibrosis, regulation metabolism plays this context.

Language: Английский

---

Effects of Ferroptosis on Cardiovascular Diseases

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 11

Published: May 4, 2023

Ferroptosis is a novel form of programmed cell death characterized by the accumulation iron-dependent lipid peroxides, which causes membrane injury. Under catalysis iron ions, cells deficient in glutathione peroxidase (GPX4) cannot preserve balance oxidative metabolism, and buildup reactive oxygen species on lipids leads to death. An increasing body evidence suggests that ferroptosis plays significant role development occurrence cardiovascular diseases. In this paper, we mainly elaborated molecular mechanisms regulating its impact disease lay groundwork for future studies prophylaxis treatment patient population.

Language: Английский

---

Effect of aqueous extract of Millettia speciosa Champ on intestinal health maintenance and immune enhancement of Cyprinus carpio

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 144, P. 109227 - 109227

Published: Nov. 19, 2023

Language: Английский

---