Hyperthyroidism

The Lancet, Journal Year: 2024, Volume and Issue: 403(10428), P. 768 - 780

Published: Jan. 23, 2024

Language: Английский

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Incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong: A population-based cohort study

PLoS Medicine, Journal Year: 2023, Volume and Issue: 20(7), P. e1004274 - e1004274

Published: July 24, 2023

Background The risk of incident diabetes following Coronavirus Disease 2019 (COVID-19) vaccination remains to be elucidated. Also, it is unclear whether the after Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) infection modified by status or differs SARS-CoV-2 variants. We evaluated incidence mRNA (BNT162b2), inactivated (CoronaVac) COVID-19 vaccines, and infection. Methods findings In this population-based cohort study, individuals without known were identified from an electronic health database in Hong Kong. first included people who received ≥1 dose vaccine those did not receive any vaccines up September 2021. second consisted confirmed patients never infected March 2022. Both cohorts followed until August 15, A total 325,715 recipients (CoronaVac: 167,337; BNT162b2: 158,378) 145,199 1:1 matched their respective controls using propensity score for various baseline characteristics. also adjusted previous when estimating conditional probability receiving vaccinations, contracting Hazard ratios (HRs) 95% confidence intervals (CIs) estimated Cox regression models. cohort, we 5,760 4,411 cases CoronaVac BNT162b2 respectively. Upon a median follow-up 384 386 days, there was no evidence increased risks 9.08 versus 9.10 per 100,000 person-days, HR = 0.998 [95% CI 0.962 1.035]; 7.41 8.58, 0.862 [0.828 0.897]), regardless type. observed 2,109 164 associated with significantly higher (9.04 7.38, 1.225 [1.150 1.305])—mainly type diabetes—regardless predominant circulating variants, albeit lower Omicron variants (p interaction 0.009). number needed harm at 6 months 406 1 additional case. Subgroup analysis revealed among fully vaccinated survivors. Main limitations our study possible misclassification bias as through diagnostic coding residual confounders due its observational nature. Conclusions There vaccination. infection, mainly diabetes. excess lower, but still statistically significant, Fully might protected

Language: Английский

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Pituitary and COVID-19 vaccination: a systematic review

Pituitary, Journal Year: 2024, Volume and Issue: unknown

Published: May 18, 2024

Abstract Purpose This systematic review aims to examine the latest research findings and assess impact of COVID-19 vaccination on pituitary gland. Method PubMed Tripdatabase were searched from January 1st, 2020 February 12th, 2024. Case reports, case series reviews related post disease included. Eligible articles tabulated analysed in attempt provide an overview epidemiology, clinical presentation, imaging, treatment, outcomes pathophysiological background disease. Results Among 23 reports included this review, hypophysitis was reported 9 patients, apoplexy (PA) 6 cases, SIADH 5 cases Isolated ACTH deficiency 2 cases. Additionally, precipitating adrenal crisis registered 7 patients tumor enlargement 1 patient after receiving vaccination. Conclusion Despite rarity these events, our suggest association between subsequent development diseases. The most common manifestations include with ADH deficiency, PA SIADH, symptoms typically emerging shortly vaccine administration. Potential pathogenetic mechanisms molecular mimicry, adjuvants vaccine-induced thrombotic thrombocytopenia (VITT), presence ACE2 receptors hypothalamus-pituitary system contributing process. These can aid diagnostic treatment decisions for presenting syndromes. Nevertheless, given safety efficacy currently available vaccines remain robust we strongly advocate continuing pursuing efforts.

Language: Английский

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AVP deficiency (central diabetes insipidus) following immunization with anti-COVID-19 BNT162b2 Comirnaty vaccine in adolescents: A case report

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: April 18, 2023

The coronavirus disease 19 (COVID-19) pandemic has prompted the development of new vaccines to reduce morbidity and mortality associated with this disease. Recognition report potential adverse effects these novel (especially urgent life-threatening ones) is therefore essential.A 16-year-old boy presented Paediatric Emergency Department polyuria, polydipsia weight loss over last four months. His past medical history was unremarkable. Onset symptoms referred be few days after first dose anti-COVID-19 BNT162b2 Comirnaty vaccine then worsened second dose. physical exam normal, without neurological abnormalities. Auxological parameters were within normal limits. Daily fluid balance monitoring confirmed polyuria polydipsia. Biochemistry laboratory analysis urine culture normal. Serum osmolality 297 mOsm/Kg H2O (285-305), whereas 80 (100-1100), suggesting diabetes insipidus. Anterior pituitary function preserved. Since parents refused give consent water deprivation test, treatment Desmopressin administered ex juvantibus diagnosis AVP deficiency (or central insipidus). Brain MRI revealed stalk thickening (4 mm) contrast enhancement, posterior bright spot on T1 weighted imaging. Those signs consistent neuroinfundibulohypophysitis. Immunoglobulin levels Low doses oral sufficient control patient's symptoms, normalizing serum urinary values daily at discharge. 2 months showed stable thicken still undetectable pituitary. Due persistence polydipsia, therapy adjusted by increasing dosage number administrations. Clinical neuroradiological follow-up ongoing.Hypophysitis a rare disorder characterized lymphocytic, granulomatous, plasmacytic, or xanthomatous infiltration gland stalk. Common manifestations are headache, hypopituitarism, To date, only time correlation between SARS-CoV-2 infection hypophysitis subsequent hypopituitarism been reported. Further studies will needed deepen possible causal link deficiency.

Language: Английский

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Acute abdomen following COVID-19 vaccination: a systematic review

Clinical and Experimental Vaccine Research, Journal Year: 2024, Volume and Issue: 13(1), P. 42 - 42

Published: Jan. 1, 2024

Conduct a systematic review of case reports and series regarding the development acute abdomen following coronavirus disease 2019 (COVID-19) vaccination, to describe possible association clinical demographic characteristics in detail. This study included report studies that focused on COVID-19 vaccination. Systematic studies, literature, letters editor, brief comments, so forth were excluded. PubMed, Scopus, EMBASE, Web Science databases searched until June 15, 2023. The Joanna Briggs Institute tool was used assess risk bias quality study. Descriptive data presented as frequency, median, mean, standard deviation. Seventeen identified, evaluating 17 patients with associated which appendicitis (n=3), pancreatitis (n=9), diverticulitis (n=1), cholecystitis (n=2), colitis (n=2). vaccine most commonly linked Pfizer-BioNTech (messenger RNA), accounting for 64.71% cases. Acute predominantly occurred after first dose (52.94%). All responded objectively medical (88.34%) surgical (11.76%) treatment discharged within few weeks. No cases death reported. is rare complication great interest practice Our based small sample patients; therefore, it recommended conduct future observational fully elucidate underlying mechanisms this association.

Language: Английский

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Effects of Different Types of COVID-19 Vaccines on Menstrual Cycles of Females of Reproductive Age Group (15-49): A Multinational Cross-Sectional Study

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: May 29, 2023

Background Globally, there are more than 474 million cases and around 6 deaths due to COVID-19. The case fatality rate was 0.5-2.8% while for 80-89 years old, it 3.7-14.8%. Given the seriousness of this infection, prevention becomes critical. Hence, introduction vaccines led a significant reduction (> 75% protection) in COVID-19 cases. On other hand, patients seeking help serious pulmonary, cardiovascular, neurological, gynecological complaints have also been recorded. Clinical studies on effects vaccination focused mostly life-or-death results rather reproductive outcomes such as menstruation, fertility, or even pregnancy outcomes. This survey conducted get evidence association between menstrual cycle irregularities some globally most prevalent vaccines. Methods An online cross-sectional by team from Taif University, Kingdom Saudi Arabia, January June 2022 females within age group (15-49 years) using semi-structured questionnaire. Data were analyzed SPSS Statistics version 22.0 presented frequency percentage. chi-square test applied p-value <0.05 considered significant. Results A total 2381 responses included. mean respondents 25±7.7 years. Around 1604 (67%) participants observed post-vaccination changes, findings (p< 0.001). strong (p=.008) found type vaccine changes (AstraZeneca 11 (36%)) after one dose. (p=.004) seen (Pfizer 543 (83%)) booster Cycles became irregular 180 (36%) prolonged 144 (29%) inoculated with Pfizer two doses (p=0.012). Conclusion Post-vaccination reported age, especially new Prospective similar insights needed. Finding co-occurring impacts infections wake emerging long-haul phenomena is crucial health.

Language: Английский

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Immune-related adverse events and disease outcomes after the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in cancer patients receiving immune checkpoint inhibitors

Cancer Immunology Immunotherapy, Journal Year: 2023, Volume and Issue: 72(10), P. 3217 - 3228

Published: July 10, 2023

Language: Английский

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Assessing Menstrual Changes Among Young Indian Females Post-SARS-CoV-2 Vaccination

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 6, 2023

Background The rollout of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has significantly enhanced immunity against disease 2019 (COVID-19), leading to a reduction in the severity illness, hospitalizations, and deaths. While various side effects vaccine have been reported, its impact on menstrual cycle remains unclear. Methods We conducted cross-sectional study involving university students who had received either partial or full vaccination SARS-CoV-2. Data was gathered through questionnaire designed assess relationship between changes SARS-CoV-2 vaccination. Results A total 773 participants, with mean age 20.6 ± 1.7 years, were included this study. participants reported significant increase irregularity cycle. observed slight length cycle, from 30.0 4.0 days (pre-vaccination) 30.5 5.6 (post-vaccination), which statistically (p<0.001). duration menstruation also increased, 4.9 5.0 (post-vaccination). However, due not (p = 0.898). Notably, there pain by after receiving 0.004). Conclusion impacted regularity during menstruation, though temporarily. Our found no differences type administered (Covishield Covaxin).

Language: Английский

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SARS-CoV-2 Vaccines-Related Endocrine Disorders: An Updated Narrative Review

Published: March 6, 2024

Abstract: The emergence of the COVID-19 pandemic has led to rapid and worldwide devel-opment investigation multiple vaccines. While most side effects these vaccines are mild transient, potentially severe adverse events may occur involve endocrine system. This narrative review aims explore current knowledge on potential following vaccination, with thyroid disorders being common. Data about pi-tuitary, adrenal, diabetes, gonadal will also be reviewed. provides a comprehensive understanding pathogenesis associated SARS-CoV-2 A PubMed/MEDLINE, Embase database (Elsevier), Google Scholar research were performed. Case reports case series, original studies, reviews written in English published online up 31 August 2023 selected is accumulating. However, their causal relationship not strong enough make definite conclusion, further studies needed clarify mechanisms linked vac-cines.

Language: Английский

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Thyroid storm after coronavirus disease 2019 mRNA vaccination in a patient with a history of Graves’ disease after coronavirus disease 2019 infection

BMJ Case Reports, Journal Year: 2024, Volume and Issue: 17(6), P. e259796 - e259796

Published: June 1, 2024

We report a case where the patient may have developed Graves’ disease after COVID-19 infection, and vaccination exacerbated condition, inducing onset of thyroid storm. Although any association between vaccine is impossible to demonstrate through single case, antecedent infection messenger ribonucleic acid synergistically contributed development followed by

Language: Английский

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