Supplementation with selenium and coenzyme Q10 in an elderly Swedish population low in selenium — positive effects on thyroid hormones, cardiovascular mortality, and quality of life

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 7, 2024

Abstract Background Selenium-dependent deiodinases play a central role in thyroid hormone regulation and metabolism. In many European countries, insufficient selenium intake may consequently lead to adverse effects on function. this randomised placebo-controlled double-blind study, we examined the effect of supplementation with coenzyme Q 10 hormonal status, cardiovascular (CV) mortality health-related quality life (Hr-QoL). Methods Free T3, free T4, reverse TSH were determined 414 individuals at baseline, yeast (200 µg/day) mg/day) concentrations, CV Hr-QoL was evaluated after 48 months using Short Form 36 (SF-36). Pre-intervention plasma low, mean 67 µg/L, corresponding an estimated 35 µg/day. Changes concentrations hormones following intervention assessed T -tests, repeated measures variance, ANCOVA analyses. Results total population, group lowest concentration baseline presented significantly higher levels lower fT3 as compared subjects highest concentration. Supplementation for 4 years increased rT3, decreased fT4, diminished increase placebo treatment ( p = 0.03, all). group, fT4 values above median associated 10-year mortality, rate among those below < 0.04, both), no difference according active group. Similarly, > decline mental vs. during follow-up, but wiped out Conclusions had beneficial respect outcomes. The initial deficient status impaired function changes can be explained by activity deiodinases. We conclude that substantial part elderly study population might suffer from suboptimal thyroidal clinical implications due deficiency. Trial registration This registered ClinicalTrials.gov has identifier NCT01443780. Since it not mandatory register time began, been retrospectively.

Language: Английский

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Childhood maltreatment and risk of endocrine diseases: an exploration of mediating pathways using sequential mediation analysis

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 8, 2024

Abstract Background Adverse childhood experiences (ACEs), including maltreatment, have been linked with increased risk of diabetes and obesity during adulthood. A comprehensive assessment on the associations between maltreatment all major endocrine diseases, as well relative importance different proposed mechanistic pathways these associations, is currently lacking. Methods Based UK Biobank, we constructed a cohort 151,659 participants self-reported data who were 30 years age or older on/after January 1, 1985. All followed from index date (i.e., 1985, their 30th birthday, whichever came later) until first diagnosis any specific (12 individual diagnoses 9 subtypes) death, end follow-up (December 31, 2019), occurred first. We used Cox models to examine association treated continuous cumulative number experienced maltreatment), ordinal 0, 1 ≥ 2), binary (< 2 2) variable, adjusted for multiple covariates. further examined having diseases using Linear Logistic Regression models. Then, sequential mediation analyses performed assess contribution four possible mechanisms suboptimal socioeconomic status (SES), psychological adversities, unfavorable lifestyle, biological alterations) observed associations. Results During an average 30.8 years, 20,885 received diseases. being diagnosed disease (adjusted hazard ratio (HR) = 1.10, 95% confidence interval 1.09–1.12). The HR was 1.26 (1.22–1.30) when comparing individuals those < maltreatment. noted most pronounced type (1.40 (1.33–1.48)) hypothalamic–pituitary–adrenal (HPA)-axis-related (1.38 (1.17–1.62)), stronger compared one (odds (95% CI) 1.24 (1.19–1.30), 1.35 (1.27–1.44), 1.52 (1.52–1.53) 2, 3, respectively). Sequential showed that consistently distinctly mediated by adversities (15.38 ~ 44.97%), while lifestyle (10.86 25.32%) additionally whereas SES (14.42 39.33%) HPA-axis-related Conclusions Our study demonstrates adverse sequel constitutes main pathway particularly Therefore, access evidence-based mental health services may also be pivotal in reducing among maltreatment-exposed individuals.

Language: Английский

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Sex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 20, 2025

Language: Английский

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Interplay between endogenous hormones and immune systems in human metapneumovirus pathogenesis and management

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

The present review explores the role of endogenous hormones, such as cortisol, melatonin, thyroid sex and insulin, in modulation immune response to a human metapneumovirus (hMPV) infection. hMPV is respiratory pathogen responsible for severe infections, particularly vulnerable populations like children elderly. virus triggers inflammatory responses through various molecular processes, including cytokine production signaling pathways. Notably, these processes can be influenced by endocrine factors, hormones. Cortisol, hypothalamic-pituitary-adrenal (HPA) axis activation, modulates inflammation but may contribute immunosuppression. Melatonin inhibits NLRP3 inflammasome, reducing lung inflammation. Thyroid hormones regulate via nuclear factor kappa B (NF-κB) JAK/STAT pathways, while hypothyroidism alter infection severity. Sex estrogens, enhance antiviral immunity, whereas androgens have variable effects on modulation. Insulin influences NF-κB suppression, with insulin resistance potentially worsening viral pathogenesis. Therapeutic implications suggest that modulating hormonal pathways could aid management. Strategies hormone therapy, glucocorticoid regulation, nanoparticle-based drug delivery are potential routes intervention. aim understand complex interplay between system during an describing mechanisms associated processes.

Language: Английский

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Inflammation in MASLD Progression and Cancer

JHEP Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101414 - 101414

Published: April 1, 2025

Language: Английский

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Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 580 - 580

Published: April 11, 2025

Recent advances in drug development allowed for the identification of THRβ-selective thyromimetic TG68 as a very promising lipid lowering and anti-amyloid agent. In current study, we first investigated neuroprotective effects on vitro human models neuroinflammation β-amyloid neurotoxicity order to expand our knowledge therapeutic potential this novel thyromimetic. Subsequently, examined metabolic inflammatory profiles, along with cognitive changes, using high-fat diet (HFD) mouse model obesity. Our data demonstrated that was able prevent either LPS/TNFα-induced response or β-amyloid-induced cytotoxicity microglial (HMC3) cells. Next, HFD-fed mice, treatment (10 mg/kg/day; 2 weeks) significantly reduced anxiety-like behavior stretch–attend posture (SAP) tests while producing 12% BW loss significant decrease blood glucose levels. Notably, these highlight close relationship between improved serum parameters reduction anxious behavior. Moreover, administration observed efficiently counteract HFD-altered central peripheral expressions mice selected biomarkers dysfunction, inflammation, neurotoxicity, revealing effects. conclusion, work provides preliminary evidence may represent opportunity interlinked diseases such obesity neurodegenerative diseases.

Language: Английский

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Loss of the ability to regenerate body appendages in vertebrates: from side effects of evolutionary innovations to gene loss

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2024, Volume and Issue: 99(5), P. 1868 - 1888

Published: May 30, 2024

ABSTRACT The ability to regenerate large body appendages is an ancestral trait of vertebrates, which varies across different animal groups. While anamniotes (fish and amphibians) commonly possess this ability, it notably restricted in amniotes (reptiles, birds, mammals). In review, we explore the factors contributing loss regenerative capabilities amniotes. First, analyse potential negative impacts on appendage regeneration caused by four evolutionary innovations: advanced immunity, skin keratinization, whole‐body endothermy, increased size. These innovations emerged as transitioned terrestrial habitats were correlated with a decline capability. Second, examine role played regeneration‐related enhancers genes initiated these fixation inability at genomic level. We propose that following cessation capacity, highly specific could represent evolutionarily neutral event. Consequently, such might promptly follow suppression side effect innovations. By contrast, genes, due their pleiotropic functions, would only take place if was accompanied additional compensated for functions unrelated regeneration, remain even after participation lost. Through review literature, provide evidence that, many cases, associated significantly delayed relative time when capability hypothesise delay may be attributed necessity restructuring developmental mechanisms create conditions where beneficial innovation organism. Experimental investigation downregulation involved but absent offers promising avenue uncover from genes. vast majority lost (about 150 humans) regulating early stages limb tail anamniotes. Disruption stage, rather than late not interfere bud development during embryogenesis, share similarities those operating stage regeneration. most approach restoring humans involve creating analogs embryonic buds using stem cell‐based tissue‐engineering methods, followed transfer amputation stump. Due required specifically more effective attempting induce both directly stump itself.

Language: Английский

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CITED1 expression in odontogenic cysts

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 12, 2024

Abstract Background Originating from odontogenic tissue, Odontogenic cysts are pathological cavities lined with epithelial cells and surrounded by fibrous connective tissue. This study investigated expression of CITED1 protein in different types cysts. Material method 40 keratocysts, radicular cysts, dentigerous were excised processed for routine paraffin wax embedding protocol. Macroscopic panoramic radiographies images used diagnosis. Demographical properties dental parameters recorded. Cystic tissues stained hematoxylin-eosin dye antibody. Semi-quantitative analysis was performed immune staining. The protein-protein interaction network, hub gene detection KEGG conducted using Cytoscape software. Result keratocysts imaged 6–8 layered cyst walls inflammatory cells. Radicular had stratified squamous epithelium varying thickness, ciliated cells, Rushton hyaline bodies. Dentigerous presented hyperplastic non-keratinized epithelium, rete ridges, immunoexpression highest followed lowest Nuclear cytoplasmic significantly elevated compared to top five targets identified, primarily showing enrichment hormone cancer related pathways. Conclusions Positive all three suggest a potential role the pathogenesis particularly keratocysts. Further investigations needed elucidate exact mechanisms underlying differential its implications development progression

Language: Английский

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Association between thyroid disorders and extra-thyroidal cancers, a review

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: 26(9), P. 2075 - 2083

Published: March 15, 2024

Language: Английский

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The relationship between Alzheimer disease and thyroiditis: A two-sample Mendelian randomization study

Medicine, Journal Year: 2023, Volume and Issue: 102(44), P. e35712 - e35712

Published: Nov. 3, 2023

This study aims to investigate the causal effect of Alzheimer disease on thyroiditis using medical English and Nature journal style. Genome-wide association data for were obtained from Mendelian Randomization (MR) platform. Single nucleotide polymorphisms (SNPs) significantly associated with identified used as instrumental variables (IVs) examine relationship between thyroiditis, employing a 2-sample MR design. Five statistical methods, including inverse-variance weighted (IVW) method, median estimation, simple mode MR-Egger regression, utilized. In study, 13 single be (P < 5 × 10-8, linkage disequilibrium r2 0.001). Upon evaluation different consistent was observed inverse variance-weighted method [IVW]: odds ratio [OR] 1.32, 95% confidence interval [CI] 1.01-1.72; estimator: OR CI randomization Egger regression: 1.29, 0.92-1.81), indicating positive correlation increased risk thyroiditis. There no evidence suggesting that could influenced by pleiotropy (Mendelian intercept 0.0058, P = .88. Our analysis reveals despite observational studies reporting an

Language: Английский

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