Association between COVID-19 vaccination and menstruation: a state of the science review

BMJ Sexual & Reproductive Health, Journal Year: 2024, Volume and Issue: 50(3), P. 212 - 225

Published: June 10, 2024

Menstrual health is a key patient-reported outcome beyond its importance as general indicator of and fertility. However, menstrual function was not measured in the clinical trials COVID-19 vaccines. The purpose this review to synthesise existing literature on relationship between vaccination outcomes.

Language: Английский

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Menstrual disorders following COVID-19 vaccination: a review using a systematic search

Frontiers in Drug Safety and Regulation, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 31, 2024

Introduction: Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of vaccines Moderna Pfizer. The aim this review, using a systematic search, is provide an overview available literature on risk vaccination. Methods: review conducted according Preferred Reporting Items for Systematic reviews Meta-Analysis (PRISMA) guidelines. A PubMed search performed 15 August 2023, including solely quantitative studies in English Dutch. Results: total 61 were included, which 40 cross-sectional studies, 18 cohort three self-controlled case series. Outcomes included wide variety disorders, changes cycle length ( n = 54), amount 44), menses 30), experience (pre)menstrual pain 21), breakthrough 18). All found higher percentage at least one disorder first different types doses. Discussion: In conclusion, evidence suggests that may cause women reproductive age. However, there need more longitudinal because important limitations study designs many studies. Although short-lived predominantly mild, it healthcare professionals be informed about these potential adverse reactions assess events clinical trials vaccines.

Language: Английский

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SARS-CoV-2 infection and female reproductive health: A narrative review

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101760 - 101760

Published: March 1, 2023

Language: Английский

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Pregnancy outcomes after frozen‐thawed embryo transfer in women with COVID‐19 history: A prospective cohort study

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(1)

Published: Jan. 1, 2024

Abstract The clinical effect of Coronavirus disease 2019 (COVID‐19) on endometrial receptivity and embryo implantation remains unclear. Herein, we aim to investigate whether a COVID‐19 history adversely affect female pregnancy outcomes after frozen‐thawed transfer (FET). This prospective cohort study enrolled 230 women who underwent FET cycles from December 2022 April 2023 in an academic fertility center. Based the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection before FET, were divided into infected group ( n = 136) control 94). primary outcome was rate per cycle. Multivariate logistic regression analysis conducted adjust for potential confounders, while subgroup restricted cubic splines used depict postinfection time interval FET. results showed that 59.6% 63.9% p 0.513). Similarly, two groups comparable rates biochemical (69.1% vs. 76.6%; 0.214) (51.7% 54.5%; 0.628). After adjustment, nonsignificant association remained between prior (OR 0.78, 95% CI: 0.42–1.46). However, odds significantly lower ≤30 days 0.15, 0.03–0.77), no statistical significance detected 31–60 >60 subgroups compared with uninfected women. In conclusion, our findings suggested SARS‐CoV‐2 had significant subsequent treatment overall, but tended be decreased if vitrified‐thawed embryos transferred within 30 infection. A 1‐month postponement should rationally recommended, further studies larger sample longer follow‐up periods are warranted confirmation.

Language: Английский

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Alterations in menstrual characteristics and associated factors in Chinese women post SARS-CoV-2 infection: a cross-sectional study

BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 18, 2025

Following a significant relaxation of restrictions in China on December 7, 2022, after surge SARS-CoV-2 infections, an uptick women presenting with menstrual disorders was observed clinics. This study aimed to explore the alterations characteristics and associated factors post infection. A cross-sectional online survey conducted among 869 non-amenorrheic adult Chinese females (aged 18–53) changes other infection-related initial The reported (group A) were compared no B). Data collected included basic individual-level information such as age, height, weight, history, reproductive disorders, chronic diseases, vaccination status, COVID-19 symptoms, (regularity, period volume, degree dysmenorrhea) Of participants, 442 (50.9%, group at least one characteristic; 171 (19.7%) experienced extended cycle, 122 (14.0%) decrease volume. Participants who more likely have pre-existing diseases (7.7% vs. 3.0%, P = 0.003) exhibit symptoms during acute (4.94 4.03, < 0.001) recovery (4.37 3.41, phases. These participants also report fever symptom (93.4% 86.9%, longer duration (2.25 1.96 days, B. Notably, fewer vaccine doses, COVID-19-related frequent (P 0.05) than may experience infection according self-report results this study.

Language: Английский

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A Cross‐Sectional Study on Post‐COVID‐19 Menstrual Abnormalities in Women of Reproductive Age Group at a Tertiary Care Hospital

Obstetrics and Gynecology International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: This study aimed to evaluate the effect of COVID-19 infection and vaccination on all menstrual cycle parameters in women reproductive age group, 18-45 years, at a tertiary care hospital. Methods: A single-center, descriptive cross-sectional was done from January 2, 2023, June 24, 2023. Sampling nonprobabilistic purposeful. Participants were recruited via calls, in-person interviews, online surveys. total 931 participants recruited, which 141 eligible for study. Descriptive statistics performed variables. Pearson's chi-square test compare categorical variables among different groups, Wilcoxon matched pair signed-rank patterns before after vaccination. Simple linear regression multiple analysis wherever necessary. p < 0.05 considered statistically significant. Results: The median 29 years. Those who reported abnormalities mainly group 18-27 (n = 62, 44.0%), resided an urban locality 123, 87.2%), employed (full-time/part-time) 57, 40.4%). Of 42 with changes, 27 (64.3%) experienced changes post-COVID-19 their first dose 15 (35.7%) dose. In this continue experience cycles. Analysis showed that having severe symptoms more likely have earlier onset (beta -2.072, p=0.040). above-normal BMI increased pain/cramps during menses 0.236, p=0.0.013). students/employed -0.365, p=0.001) 0.182, p=0.024) mood swings/tension/irritability. On comparing duration postvaccination it found latter had late-onset short-term effect, while former early-onset long-term menses. Conclusion: Our shows there is evidence irregularities following revealed influence cycles, posing higher risk, but effects menstruation independent one another are be studied further.

Language: Английский

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Adverse Menstrual Events Reported After and Before (or Without) COVID‐19 Vaccination: A Systematic Review and Meta‐Analysis of Comparative Observational Studies

Pharmacoepidemiology and Drug Safety, Journal Year: 2024, Volume and Issue: 33(8)

Published: Aug. 1, 2024

ABSTRACT Background Reports of adverse menstrual events emerged during the COVID‐19 vaccination campaign in multiple countries. This raised question whether these reports were caused by vaccines. The aim this systematic review was to evaluate comparative studies on topic (registered at PROSPERO [CRD42022324973]). Methods We included observational such as cohort and surveys comparing response self‐reported questionnaires between post‐ versus pre‐vaccination data. PubMed Cochrane Library searches conducted 1 September 2023. primary outcome incidence any prespecified event, measure risk ratio. meta‐analysis using Mantel–Haenszel method random effects model. summarized results factors well key findings included. Results retrieved 161 references from electronic databases additional sources lists. Of those, we considered 21 studies. event reported 12 resulted a pooled estimate (risk ratio 1.13; 95% CI, 0.96–1.31) that did not favor group. analysis constrained considerable clinical statistical heterogeneity. Risk for changes history infection, concern about vaccines, smoking, previous cycle irregularities, depression, stress, other issues. Conclusions group heterogeneity prevalent among Most suggested temporary, minor, nonserious.

Language: Английский

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The Evaluation of Menstrual Alterations in Mexican Women After Vaccination Against COVID-19

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

Introduction Menstrual changes after COVID-19 vaccination suggest a secondary connection to the immune response rather than specific component of vaccine. The evaluation these alterations in women with same and multiple schedules will provide valuable information. Methods An observational, cross-sectional study was carried out; data were collected through survey 164 vaccinated at American British Cowdray (ABC) Santa Fe Medical Center Hospital Mexico City. validated by Delphi method. Results applied from March 2023 February 2024. Post-vaccination menstrual occurred 48.1%; most frequent alteration menorrhagia 20.7% pain accompanied menstruation 27.4%. Fifty-seven percent had history previous infection. There no significant associations between bleeding vaccination, infection, age group (p>0.9). However, who received doses vaccines higher risk suffering abnormalities 36.6%. Conclusion incidence disorders this post 49%. patients single regimen similar 47% 48%, where there is statistical significance. greatest number seen first dose 36%, probably due immunity they acquired different types vaccination. Vaccination very effective way prevent severity infection; it has an impact on terms metrorrhagia. against associated small cycle, without Women receiving vaccine amount specifically amount.

Language: Английский

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COVID-19 and menstrual-related disturbances: a Spanish retrospective observational study in formerly menstruating women

Frontiers in Global Women s Health, Journal Year: 2024, Volume and Issue: 5

Published: July 30, 2024

Introduction Four years after the start of pandemic, there is limited evidence on impact COVID-19 women's health regardless their reproductive status. Objective The aim was to analyze prevalence and associated factors menstrual-related disturbances in formerly menstruating women following SARS-CoV-2 infection. Study design A retrospective observational study adult Spain conducted during month December 2021 using an online survey ( N = 17,512). present analysis includes a subpopulation SARS-CoV-2-infected n 72). collected data included general characteristics, medical history, specific information COVID-19. Chi-square Mann-Whitney U -tests were performed. Bivariate logistic regression then performed investigate possible associations between occurrence Results 38.8% participants experienced Among these, unexpected vaginal bleeding (20.8%) most common event, followed by spotting (11.1%) Table 1 ). Other reported changes length (shorter 12.5%) flow (heavier 30.3%) menstrual comparison previous experience. Regression revealed that being perimenopausal woman [adjusted odds ratio (AOR) 4.721, CI 95%, 1.022–21.796, p 0.047] having diagnosis menorrhagia (AOR 5.824 1.521–22.310, 0.010) with event. Conclusion These findings could help professionals provide patients up-to-date scientific empower them actively manage health, especially societies where still taboo.

Language: Английский

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COVID-19 Vaccines and the Menstrual Cycle: A Cross-Sectional Study

Current Respiratory Medicine Reviews, Journal Year: 2023, Volume and Issue: 20(1), P. 24 - 30

Published: Dec. 1, 2023

Objective: This study aimed to explore the impact of various COVID-19 vaccines on menstrual cycle Jordanian women. Materials and Methods: We conducted a retrospective analysis tracked changes using an anonymous questionnaire written in local language. received 732 responses, after exclusions, 617 responses were analyzed. The covered six sectors: demographics, medical history, infection vaccination status, obstetric gynecological specific questions about length, flow, any symptoms before each vaccine shot. Participants included females who had type vaccine. Results: Among participants analyzed, two-thirds between ages 20-35, majority normal BMI (59.6%). Most single, nulliparous, never used contraception methods (79.3%, 82.0%, 93.8%, respectively). Only small percentage other risk factors influencing changes, such as surgical procedures (10.5%) medications (8.10%). Baseline information was recorded. Forty percent experienced duration, approximately one-fifth reported heavier more severe premenstrual syndrome (PMS) symptoms. Body mass index (BMI) directly correlated with bleeding intensity vaccination. Parity weakly proportional However, parity did not significantly correlate PMS symptoms, or cramps Conclusion: In population young, non-sexually active women BMI, most experience significant their cycles receiving shorter bleeding, frequent, painful, post-vaccination.

Language: Английский

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