Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Aims This investigation examined the possibility of a relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients. Methods Adults with T2DM who were included National Health Nutrition Examination Survey (NHANES) 1999 2020 subjects current cross-sectional investigation. Low estimated glomerular filtration rate (eGFR) (< 60 mL/min/1.73 m ) or albuminuria (urinary albumin-to-creatinine (ACR) ≥ 30 mg/g) patients diagnostic criteria for DKD. Weighted multivariable logistic regression models generalized additive used to investigate independent relationships NLR levels DKD, albuminuria, low-eGFR. Additionally, we low-eGFR other inflammatory markers, such as aggregate index systemic inflammation (AISI), immune-inflammation (SII), system response (SIRI), platelet-to-lymphocyte (PLR) monocyte-to-lymphocyte (MLR). Their capabilities evaluated contrasted using receiver operating characteristic (ROC) curves. Results 44.65% 7,153 participants recruited this study males. prevalent 31.76%, 23.08%, 14.55% cases, respectively. Positive correlations seen prevalences Subgroup analysis interaction tests revealed that associations not significantly different across populations. In addition, MLR, SII SIRI showed positive prevalence ROC discovered when compared markers (MLR, PLR, SII, SIRI, AISI), may demonstrate more discriminatory power accuracy assessing risk Conclusion Compared serve effective potential marker identifying US elevated NLR, should be closely monitored their renal function.

Language: Английский

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The Role of Estrogen across Multiple Disease Mechanisms

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(8), P. 8170 - 8196

Published: July 29, 2024

Estrogen is a significant hormone that involved in multitude of physiological and pathological processes. In addition to its pivotal role the reproductive system, estrogen also implicated pathogenesis diseases. Nevertheless, previous research on diseases, including Alzheimer’s disease, depression, cardiovascular diabetes, osteoporosis, gastrointestinal estrogen-dependent cancers, has concentrated single disease area, resulting lack comprehensive understanding cross-disease mechanisms. This brought some challenges current treatment methods for these because as potential therapeutic tool not yet fully developed potential. Therefore, this review aims comprehensively explore mechanism seven types The objective study describe relationship between each estrogen, ways which participates regulating mechanisms, outline efficacy treating diseases clinical practice. By studying variety it hoped more accurate theoretical basis guidance future strategies will be provided, thus promoting effective management

Language: Английский

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Testosterone deficiency and chronic kidney disease

Journal of Clinical & Translational Endocrinology, Journal Year: 2024, Volume and Issue: 37, P. 100365 - 100365

Published: Aug. 14, 2024

Testosterone's biological functions are extensive, influencing reproductive and systemic health. It plays a vital role in sexual functions, muscle protein synthesis, bone metabolism, fat distribution, cardiovascular The hormone also affects mood, cognitive function, erythropoiesis, underscoring its importance both physical mental Testosterone deficiency, or male hypogonadism, is increasingly recognized as significant health issue affecting various bodily systems, the context of chronic kidney disease (CKD). Recent research indicates complex interplay between testosterone levels renal health, suggesting that hypogonadism may impact be impacted by CKD. latter characterized gradual loss millions globally often associated with diabetes mellitus, arterial hypertension, autoimmune diseases. Men CKD frequently experience lower levels, which can exacerbate wasting, reduce quality life, increase risk. Overall, low patients increased morbidity mortality. Several mechanisms explain relationship deficiency. uremic environment disrupts hypothalamic-pituitary-gonadal axis, impairing production. Nutritional deficiencies inflammation common further suppress gonadal function. consequences profound, studies replacement therapy (TRT) might improve clinical outcomes, though long-term effects causal relationships remain under investigation. potential benefits TRT significant. enhance mass strength, address anemia stimulating density, possibly offer improving body composition insulin sensitivity. General symptoms such deteriorated psychological, wellbeing, improved TRT. However, these must weighed against risks. fluid retention, existing heart failure, particularly pre-existing comorbidities. Additionally, concerns about progression via several affected pathways involving tubular integrity exist, highlighting need for careful patient selection monitoring. Understanding this crucial developing comprehensive treatment strategies endocrine dysfunctions, integrated care, means good collaboration subspecialists like nephrologists, endocrinologists, urologists primary care providers, aiming to outcomes life while mitigating adverse effects.

Language: Английский

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Urinary Fetuin-A with Specific Post-Translational Modification in Type 1 Diabetes Patients with Normoalbuminuria and Preserved Kidney Function

Diagnostics, Journal Year: 2025, Volume and Issue: 15(4), P. 423 - 423

Published: Feb. 10, 2025

Background/Objectives: Post-translationally modified peptide fragments of fetuin-A (FetA) were identified as a potential biomarker diabetic kidney disease (DKD). An independent association between urinary FetA-derived levels (uPTM3-FetA) and DKD progression in patients with type 2 diabetes (T2D) was evidenced. This study aimed to explore uPTM3-FetA excretion its associations insulin resistance, inflammatory metabolic biomarkers 1 (T1D), the normal albuminuria estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m2. Methods: aliquots 24 h urine specimens, routine laboratory renal, tests, adipokines (leptin, adiponectin, resistin), assessed glucose disposal (eGDR), measured cohort 169 adult T1D patients. To evaluate changes early renal dysfunction, divided according median eGFR. Above- below-median-eGFR groups considered having declining function, respectively. Results: The (IQR) level 11.7 (8.43–16.65 µg/24 h), no significant difference males females, well function However, sex-specific analysis revealed significantly higher male lower eGFRs, when compared those whereas such observed female BMI, hs-CRP, resistin HDL-cholesterol predictors excretion. Conclusions: Our results implicate role detection an dysfunction T1DM pinpoint importance approach diagnostics research.

Language: Английский

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Epidemiological trends in diabetic renal complications in United States adults: A center for disease control and prevention wide-ranging online data for epidemiologic research analysis (1999-2020)

World Journal of Nephrology, Journal Year: 2025, Volume and Issue: 14(2)

Published: April 8, 2025

BACKGROUND Renal complications of diabetes mellitus pose a significant public health challenge, contributing to substantial morbidity and mortality globally. Understanding temporal trends regional disparities in related diabetic nephropathy is crucial for guiding targeted interventions policy decisions. AIM To display the mortality. METHODS A retrospective analysis was conducted using death certificate data from center disease control prevention (CDC) wide-ranging online epidemiologic research (WONDER) database, spanning 1999 2020, investigate renal adults aged 35 or above. Age-adjusted rate (AAMR) per 100000 persons annual percent change (APC) were computed, with stratification by year, sex, race/ethnicity, geographic region. RESULTS Between total 525804 deaths occurred among 85+ years due renal-related issues associated diabetes. AAMR adult patients showed consistent increase 1.6 34.9 2020 (average APC [AAPC]: 17.23; 95% confidence interval [CI]: 13.35-28.79). Throughout study period, men consistently had higher (overall men: 17.8; 95%CI: 17.7-17.9). In 1999, 1.8, increasing 44.2 (AAPC: 17.54; 13.09-29.53), while women, it rose 27.6 15.55; 13.35-21.10). American Indian/Alaska Native exhibited highest overall (36.1; 35.2-36.9), followed Black/African (25.5; 25.3-25.7). The observed Western (AAMR: 16.6; 16.5-16.7), Midwestern region 14.4; 14.314.4). Significant variations different states, Oklahoma recording (21.2) Connecticut lowest (7). CDC WONDER database could potentially have omissions inaccuracies. It does not provide outside available variables. Furthermore, dataset after included this study. CONCLUSION Our findings highlight an alarming rise United States over past two decades, concerning across demographic factors. These results underscore urgent need interventions, policies, protocols address growing burden substantially reduce rates States. This will help improve outcome identifying communities at risk implementing tailored assistance them.

Language: Английский

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Fenoxaprop-P-Ethyl Herbicide Induces Biochemical, Histopathological, and Immunohistochemical Alterations in the Kidneys and Testes of Rats

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108953 - 108953

Published: May 1, 2025

Language: Английский

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Factors affecting serum PFAS concentrations among US females with surgically and naturally induced menopause: data from NHANES 2003–2018

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(35), P. 84705 - 84724

Published: June 27, 2023

Language: Английский

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The influence of toxic advanced glycation end-products (TAGEs) on the development of diabetic nephropathy

Archives of Ecotoxicology, Journal Year: 2024, Volume and Issue: 6(1), P. 13 - 16

Published: June 29, 2024

Acquired blindness, end-stage renal failure, accelerated atherosclerosis, and other neuropathies are all primarily caused by diabetic complications. Through a variety of metabolic disturbances, chronic hyperglycaemia plays primary role in the ethiology micro- macrovascular problems. The synthesis several kinds advanced glycation end products (AGEs) was enhanced high glucose. It recently shown that AGEs (AGE-2) produced from glyceraldehyde crucial to pathophysiology angiopathy individuals. receptor for (RAGE), which is present on cell types diabetes-affected cells, great interest. According recent research, interaction between RAGE AGE-2, structure toxic or TAGE, can change gene expression, intracellular signalling, release pro-inflammatory molecules, generation reactive oxygen species (ROS), factors complications involves such as (ROS). Recent research indicates affect these processes.

Language: Английский

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Sexual Dimorphism in Impairment of Acetylcholine-Mediated Vasorelaxation in Zucker Diabetic Fatty (ZDF) Rat Aorta: A Monogenic Model of Obesity-Induced Type 2 Diabetes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11328 - 11328

Published: Oct. 21, 2024

Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males females. This study examines sex differences the of type 2 (T2D) an established monogenic model obesity-induced T2D, Zucker Diabetic Fatty (ZDF) rats. Acetylcholine (ACh) responses were assessed phenylephrine pre-contracted rings before after apocynin, a NADPH oxidase (NOX) inhibitor. The mRNA expressions aortic endothelial NOS (eNOS), key NOX isoforms also measured. We demonstrated following: (1) had contrasting vasorelaxation ZDF rats, impairing relaxation to ACh females while enhancing it male rats; (2) inhibition NOX, major source superoxide vasculature, restored female (3) eNOS NOX4 elevated (but not male) rat aortas compared their respective leans. highlights sexual dimorphism ACh-mediated aorta suggesting may play role impaired observed

Language: Английский

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Evaluation of renal function in patients with type 1 diabetes mellitus implementing reproductive function in assisted reproductive technology protocols

Journal of obstetrics and women s diseases, Journal Year: 2024, Volume and Issue: 73(1), P. 67 - 79

Published: March 26, 2024

The prevalence of type 1 diabetes mellitus has increased significantly among women reproductive age over the past two decades. Despite improved glycemic control and intensified insulin therapy, patients with still suffer from many problems, which often makes this group potential participants in assisted technology programs under certain conditions. Diabetic nephropathy is one most serious complications mellitus. It ranks first structure chronic kidney disease a common cause end-stage renal failure, disability, mortality. Early diagnosis identification specific markers diabetic will allow for timely initiation nephroprotective therapy to slow progression damage. This review article based on results PubMed, Frontiers, ResearchGate search queries 2016 2023. We analyzed worldwide domestic data impact function, influence sex hormones nephropathy, importance personalized approach at pre-pregnancy stage, especially those planning treatment within programs.

Language: Английский

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