Application of network pharmacology in synergistic action of Chinese herbal compounds

Theory in Biosciences, Journal Year: 2024, Volume and Issue: 143(3), P. 195 - 203

Published: June 18, 2024

Language: Английский

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The value of luteinizing hormone basal values and sex hormone-binding globulin for early diagnosis of rapidly progressive central precocious puberty

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 22, 2024

Objective This study aimed to investigate the diagnostic value of luteinizing hormone (LH) basal values and sex hormone-binding globulin (SHBG) for rapidly progressive central precocious puberty (RP-CPP). Methods A total 121 girls presenting with secondary sexual characteristics were selected from Department Pediatric Endocrinology, Lianyungang Clinical Medical College Nanjing University, May 2021 June 2023. The children followed up 6 months divided into three groups: RP-CPP group (n=40), slowly (SP-CPP) premature thelarche (PT) (n=41). differences in LH SHBG among groups compared. ROC curves drawn analyze identifying RP-CPP. Results Significant observed age, height, predicted adult height (PAH), weight, body mass index (BMI), bone age (BA), BA-chronological (CA), basal, peak, FSH peak/FSH estradiol (E2), testosterone, levels between SP-CPP PT (P < 0.05). was higher than that group, while lower latter two groups, these statistically significant When ≥0.58 IU/L ≤58.79 nmol/L, sensitivity diagnosing 77.5% 67.5%, specificity 66.7% 74.1%. Conclusion Detection allows early diagnosis progression puberty.

Language: Английский

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Network pharmacology provides new insights into the mechanism of traditional Chinese medicine and natural products used to treat pulmonary hypertension

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156062 - 156062

Published: Sept. 17, 2024

Language: Английский

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Exploration of the molecular mechanism of modified Danggui Liuhuang Decoction in treating central precocious puberty and its effects on hypothalamic-pituitary-gonadal axis hormones

Hereditas, Journal Year: 2025, Volume and Issue: 162(1)

Published: April 8, 2025

Language: Английский

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The neurobiology of plant-based therapeutics in women's reproductive health: mechanisms, efficacy, and clinical translation

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 20, 2025

This review examines the neurobiological mechanisms by which plant-derived compounds influence women's reproductive health through neuroendocrine-reproductive axis. Gynecological disorders frequently present with neurological manifestations, including cognitive decline in perimenopause, anxiety and depression polycystic ovary syndrome (PCOS), central sensitization endometriosis. Bioactive from medicinal plants, polyphenols phytoestrogens, demonstrate therapeutic potential their anti-inflammatory, antioxidant, neuromodulatory properties. These multi-target offer advantages over conventional single-target therapies simultaneously regulating multiple physiological processes. The explores applications specific gynecological conditions discusses development of dietary supplements functional foods incorporating these ingredients. growing market for products presents opportunities innovative formulations enhanced bioavailability personalized approaches. Future research directions include integrating neuroimaging herbal research, improving clinical translation, establishing regulatory frameworks global application interventions to enhance female health.

Language: Английский

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Mechanistic insights into EGCG's preventive effects on obesity-induced precocious puberty through multi-omics analyses

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Epigallocatechin gallate (EGCG) has demonstrated potential effects on obesity-induced precocious puberty, but the underlying mechanisms remain unclear.

Language: Английский

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Revealing Molecular Mechanisms of the Bioactive Saponins from Edible Root of Platycodon grandiflorum in Combating Obesity

Plants, Journal Year: 2024, Volume and Issue: 13(8), P. 1123 - 1123

Published: April 17, 2024

Obesity has emerged as a significant health concern, it is disease linked to metabolic disorders in the body and characterized by excessive accumulation of lipids. As plant-derived food, Platycodon grandiflorum (PG) was reported many studies, indicating that saponins from PG can improve obesity effectively. However, anti-obesity its mechanisms have not been fully identified. This study identified active their molecular targets for treating obesity. The TCMSP database used obtain information on 18 PG. target 115 44 core targets. GO KEGG analyses using genes PG-active screened GeneCards, OMIM, Drugbank, DisGeNet showed PI3K-Akt pathway, JAK-STAT MAPK pathway were major pathways involved effects saponins. BIOVIA Discovery Studio Visualizer AutoDock Vina perform docking process results. results could bind therapeutic play an obesity-inhibitory role. this laid foundation further research mechanism provided new direction development functional food. studied combating through various signaling pathways, prosapogenin D be develop potential drug.

Language: Английский

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Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(33), P. 18537 - 18551

Published: Aug. 12, 2024

Diabetes mellitus is a typical metabolic disease that has become major threat to human health worldwide. Ginseng polypeptide (GP), small molecule active substance isolated from ginseng, shown positive hypoglycemic effects in preliminary studies. However, its mechanism ameliorating multiorgan damage db/db mice unclear. In this study, we utilized network pharmacology, molecular docking, and animal experiments explore the targets biological mechanisms of GP ameliorate T2DM. The results showed improves T2DM by inhibiting inflammation oxidative damage, thereby alleviating hyperglycemia, insulin resistance, mice. These are potentially mediated through PI3K-Akt signaling pathway MAPK pathway. This study establishes GP's efficacy provides robust theoretical basis for development new drugs or functional foods treating disease.

Language: Английский

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The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer’s disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113893 - 113893

Published: Dec. 24, 2024

Language: Английский

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Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 7, 2024

Background The mechanistic target of rapamycin (mTOR) signaling pathway has a significant effect on central precocious puberty (CPP). However, the causality between mTOR-dependent circulating protein levels and CPP is still unclear. Our aim to assess effects seven using Mendelian randomization (MR). Methods Instrumental variables (IVs) for were retrieved from proteomics-GWAS INTERVAL study eQTLGen. summary-level genetic datasets outcome obtained FinnGen Consortium. Inverse-variance weighted (IVW) was used as primary method pleiotropy, heterogeneity robustness analyses detected sensitivity analysis. Positive exposures in discovery cohort would be revalidated validation cohort. Results This two-sample MR revealed causal association eIF4G level plasma both (IVW: OR = 0.45, 95% CI 0.22–0.91, p 0.026) 0.24–0.85, 0.014). Conclusions There CPP. Whether can prevention or treatment needs explored further studies.

Language: Английский

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