Correlation Between Thyroid-Stimulating Hormone (TSH) and Liver Function Test Values in North Karnataka Patients Admitted to a Tertiary Care Hospital DOI Open Access

Sanjana Murali Krishna,

Shreelaxmi V. Hegde,

Monisha Chellathurai

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Background: Thyroid hormones play a pivotal role in regulating metabolic processes, including liver metabolism. The interplay between thyroid function and enzymes is complex, with dysfunction potentially impacting function. relationship thyroid-stimulating hormone (TSH) levels parameters particularly noteworthy, especially areas like North Karnataka, India, where dietary environmental factors may impact disorders. Aim objectives: principal objective of this research to explore the association TSH individuals from Karnataka. Secondary objectives include examining levels, blood pressure, prevalence comorbidities study population. Materials methods: This retrospective observational included 75 patients admitted tertiary care hospital Patients who had undergone both tests were study. Data on pressure (like hypothyroidism, hyperthyroidism, hypertension, gastritis, alcohol-related disease, anemia, chronic obstructive pulmonary disease (COPD), arthritis, diabetes mellitus, migraine, uterine disorder) also collected analyzed. Results: population comprised 48 females (64%) 27 males (36%), mean age 46.52 years. irregularities observed 16 (21.4%), hypothyroidism being predominant disorder, accounting for 14 cases (18.7%). distribution mellitus (14 patients; 18.7%), anemia (19 25.3%), migraine (18 24%), hypertension (17 22.7%), gastritis (10 13.3%), COPD (nine 12%), disorders (four 5.3%), arthritis (three 4%), (eight 10.6%). It important note that some presented more than one comorbidity, which result an overlap total count specific conditions reported. Discussion: absence significant correlation contrasts previous research, suggesting regional habits these associations. high disorders, underscores importance monitoring presence such as further complicates clinical picture highlights need comprehensive healthcare approaches. Conclusion: did not find findings emphasize continued into complex interactions metabolism, regions unique influences. Public health initiatives should focus addressing related

Language: Английский

Metabolic dysfunction-associated steatotic liver disease in children DOI
Nidhi Goyal, Stavra A. Xanthakos, Jeffrey B. Schwimmer

et al.

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 331090

Published: Jan. 23, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty disease, is the most common cause of chronic in children. MASLD encompasses a spectrum and can be severe, with 10% affected children presenting advanced fibrosis. While biopsy remains accurate method for diagnosing staging MRI proton density fat fraction magnetic resonance elastography are reliable non-invasive measures assessing steatosis fibrosis, respectively. associated multiple comorbidities including type 2 diabetes, hypertension, dyslipidaemia, decreased bone mineral density, obstructive sleep apnoea, anxiety depression. Currently, there no pharmacological treatments available children, highlighting urgent need paediatric clinical trials. A diet low free sugars promising reducing decreasing alanine aminotransferase, surrogate marker hepatic inflammation. Emerging data indicate that present under 6 years age, which was considered rare. The intricate interplay genetics may inform future therapeutics prognostication, PNPLA3 gene showing evidence association risk severity steatohepatitis. complex affecting one ten increased early mortality risk. More dedicated studies needed to advance our understanding this find effective treatments.

Language: Английский

Citations

4
Regulation of bone homeostasis: signaling pathways and therapeutic targets DOI Creative Commons

Zebin Wu,

Wenming Li,

Kunlong Jiang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 24, 2024

As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both formation by osteoblasts and resorption osteoclasts constitute reconstruction homeostasis. The equilibrium of homeostasis governed many complicated signaling pathways that weave together to form an intricate network. These coordinate the meticulous processes resorption, ensuring structural integrity vitality skeletal system. Dysregulation homeostatic regulatory network contributes development progression diseases. Significantly, imbalanced further disrupts triggers cascade reaction exacerbates disease engenders deleterious cycle. Here, we summarize influence on homeostasis, elucidating interplay crosstalk among them. Additionally, review mechanisms underpinning imbalances across diverse landscapes, highlighting current prospective therapeutic targets clinical drugs. We hope this will contribute holistic understanding molecular sustaining which are promising research shed light targeted

Language: Английский

Citations

9
The mechanism of action of indole-3-propionic acid on bone metabolism DOI

Huimin Xu,

Yingzhe Luo,

Yi An

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

IPA binds to AhR and PXR receptors, regulating bone metabolic disorders.

Language: Английский

Citations

1
Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease DOI Creative Commons
Yuhong Fan, Siyao Zhang, Ye Wang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.

Language: Английский

Citations

1
The association between the ZJU index and bone mineral density (BMD) among patients with type 2 diabetes mellitus DOI Creative Commons
Yuan Zhang, Guanhua Chen, Yali Jing

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Background Previous studies have suggested that type 2 diabetes mellitus (T2DM) is associated with poor bone health, including osteoporosis (OP) and osteopenia. The ZJU index, a novel calculation integrates fasting plasma glucose (FPG), body mass index (BMI), triglyceride (TG), alanine aminotransferase (ALT) to aspartate (AST) ratio, strongly glucolipid metabolism insulin resistance (IR). In this study, we explored the association of mineral density (BMD) OP/osteopenia, investigated predictive effect on OP/osteopenia in patients T2DM. Methods This cross-sectional study included 496 T2DM aged > 50 years. clinical data were collected BMD femoral neck (FN), left hip (LH), lumbar spine (LS) measured. between BMDs levels was by adjusting for covariates utilizing multiple linear regression analyses. Multivariable logistic constructed identify independent factors OP osteopenia, receiver operating characteristic (ROC) curves used display diagnostic performance according area under ROC curve (AUC). Results osteopenia showed significantly higher than those normal (39.387 ± 3.558, 38.112 2.552 vs 35.192 2.600, p < 0.001). Spearman’s correlation analysis negatively correlated FN (r = -0.39, 0.001), LH -0.35, LS -0.32, indicated negative (β -0.006, 0.009), -0.155, 0.011) after adjusted covariates. Meanwhile, results revealed contributing factor risk individuals years (OR 1.446, 95% CI: 1.087 ~ 1.923, 0.011; OR 1.878, 1.218 3.715, 0.039, respectively). provided AUC value 0.695 0.716 T2DM, respectively. Conclusions A high an increasing OP. expected be potential detecting decreased middle-aged elderly patients. Early intervention increased may further reduce incidence OP, addition focusing biomarker practice.

Language: Английский

Citations

0
Association between liver fibrosis and osteoporosis in adults aged 50 and older: insights from the Bushehr Elderly Health Program DOI
Akbar Soltani, Amirhossein Aghakhani, Hojat Dehghanbanadaki

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Emerging Trends in MAFLD and MASH DOI

Samita Garg,

Nizar N. Zein

Diabetes Technology & Therapeutics, Journal Year: 2025, Volume and Issue: 27(S1), P. S227 - S237

Published: March 1, 2025

Language: Английский

Citations

0
Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota DOI Creative Commons
Jing Zhang, Zhen Sun,

Lili Xu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.

Language: Английский

Citations

0
Metabolic dysfunction–associated fatty liver disease and osteoporosis: the mechanisms and roles of adiposity DOI
Jie Tao,

Hong Li,

Honggang Wang

et al.

Osteoporosis International, Journal Year: 2024, Volume and Issue: 35(12), P. 2087 - 2098

Published: Aug. 13, 2024

Language: Английский

Citations

3
ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1 DOI Creative Commons
Ting Liu,

Luxu Wang,

Tuo Shi

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 3903 - 3919

Published: Aug. 1, 2024

Bone loss is a common complication of type 2 diabetes mellitus (T2DM). Circadian rhythms play significant role in T2DM and bone remodeling. Eldecalcitol (ED-71), novel active vitamin D analog, has shown promise ameliorating T2DM. We aimed to investigate whether the circadian rhythm coregulator BMAL1 mediates anti-osteoporotic effect ED-71 its associated mechanisms.

Language: Английский

Citations

1