Association between METS-IR index and obstructive sleep apnea: evidence from NHANES

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Insulin resistance (IR) is strongly associated with obstructive sleep apnea (OSA). Whereas, few studies have focused on the potential association between Metabolic Score for Resistance (METS-IR), a novel non-insulin-dependent IR index, and OSA. Subjects from National Health Nutrition Examination Survey (NHANES) spanning 2005-2008 2015-2018 were recruited. The relationship METS-IR other indices OSA was explored through three logistic regression analysis models restricted cubic spline (RCS) curves. Receiver operating characteristic (ROC) curves used to assess diagnostic value of these indicators On basis age, sex, race, body mass index (BMI), hypertension, diabetes, cardiovascular disease (CVD), subgroup analyses conducted test robustness relationship. A total 8,306 participants enrolled, an prevalence 30.69%. After adjusting confounders, METS-IR, triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio, glucose Index (TyG), homeostatic model assessment insulin (HOMA-IR) showed positive associations prevalence. In highest tertile TG/HDL-C, TyG HOMA-IR, 2.96-fold, 1.42-fold, 1.29-fold, 1.41-fold higher, respectively, compared lowest (METS-IR: OR = 2.96, 95% CI: 2.50, 3.52, P < 0.0001; TG/HDL-C: 1.42, 1.17, 1.73, 0.001; index: 1.29, 1.07, 1.55, 0.008; HOMA-IR: 1.41, 1.18, 1.69, 0.001). ROC revealed that had accuracy (AUC 0.652). four remain stable across most cases (P interaction > 0.05); however, all them show significant interactions diabetes 0.05). positively shows superior index.

Language: Английский

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Association of non-insulin-based insulin resistance indices with disease severity and adverse outcome in idiopathic pulmonary arterial hypertension: a multi-center cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 3, 2024

Abstract Background Insulin resistance (IR) plays an important role in the pathophysiology of cardiovascular disease. Recent studies have shown that diabetes mellitus and impaired lipid metabolism are associated with severity prognosis idiopathic pulmonary arterial hypertension (IPAH). However, relationship between IR is poorly understood. This study explored association four indices IPAH using data from a multicenter cohort. Methods A total 602 consecutive participants were included this January 2015 December 2022. The metabolic score for (METS-IR), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, glucose (TyG) index, triglyceride-glucose-body mass index (TyG-BMI) used quantify levels patients IPAH. correlation non-insulin-based long-term adverse outcomes was determined multivariate Cox regression models restricted cubic splines. Results During mean 3.6 years’ follow-up, 214 experienced all-cause death or worsening condition. Compared low intermediate-low risk patients, TG/HDL-C ratio (2.9 ± 1.7 vs. 3.3 2.1, P = 0.003) METS-IR (34.5 6.7 36.4 7.5, < 0.001) significantly increased high intermediate-high patients. correlated well-validated variables reflected IPAH, such as cardiac stroke volume index. Multivariate analyses indicated TyG-BMI (hazard [HR] 1.179, 95% confidence interval [CI] 1.020, 1.363 per 1.0-standard deviation [SD] increment, 0.026) (HR 1.169, CI 1.016, 1.345 1.0-SD 0.030) independently predicted outcomes. Addition improved reclassification discrimination ability beyond European Society Cardiology (ESC) score. Conclusions can predict clinical events, while also provide incremental predictive performance ESC stratification.

Language: Английский

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Distribution and Related Influencing Factors of AMH Level in Family-Planning Women of Childbearing Age: A Cross-Sectional Study from Beijing, China

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 99 - 107

Published: Jan. 1, 2025

This study aimed to analyze the distribution and factors influencing anti-Müllerian hormone (AMH) levels among family-planning women of childbearing age in Beijing, China. We collected data 3,236 who underwent pre-pregnancy examinations at Xicheng District Maternal Child Health Hospital Beijing between October 2021 July 2024. Collected included age, education level, ethnicity, height, weight, systolic diastolic blood pressure. calculated body mass index (BMI) each participant. The test results AMH, fasting glucose (FBG), thyroid-stimulating (TSH), creatinine (Cr), alanine aminotransferase, hemoglobin platelet count. A structured questionnaire was used document subjects' dietary lifestyle habits, environmental factors, emotional mental stress statuses. patients were divided into groups (≥36 years versus ≤35 years) compared them. Two different AMH level analyzed using a logistics model. decreased with median <2.0 ng/mL for subjects aged ≥36 years. Significant intergroup differences noted FBG, BMI, pressure, smoking rate, life-related level. logistic regression analysis suggested that negative factor affecting both (P=0.000 0.002, respectively). Hemoglobin educational also important influential ≤ 35 but not those ≥ 36 gradually age. Although nutritional status significantly impacted their effects thereafter. Thus, is considered an reproductive boundary

Language: Английский

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METS-IR as an important predictor of neurological impairment severity in patients with severe cerebral infarction: a multicenter study based on the Chinese population

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 25, 2024

Insulin resistance (IR) is linked to an increased risk of neurological impairment following a stroke and may contribute poor prognosis in affected patients. The metabolic score for the insulin index, shortened as METS-IR, generally serves surrogate index IR. However, its association with severity patients severe cerebral infarction (CI) intensive care units (ICU) has not been fully established.

Language: Английский

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Changes in the metabolic score for insulin resistance index for risk prediction of stroke in middle-aged and older Chinese population

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(4), P. 599 - 610

Published: Nov. 19, 2024

Language: Английский

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Is Insulin Resistance a High-Risk Factor for Postmenopausal Endometrial Cancer: Insights from the Triglyceride Glucose (TyG) Index and the Metabolic Score for Insulin Resistance (METS-IR)

International Journal of Women s Health, Journal Year: 2024, Volume and Issue: Volume 16, P. 2355 - 2363

Published: Dec. 1, 2024

To evaluate the insulin resistance in patients with menopause who were newly diagnosed endometrial cancer and its association disease development.

Language: Английский

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Relationship between the Mediterranean Diet and Vascular Function in Subjects with and without Increased Insulin Resistance

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3106 - 3106

Published: Sept. 14, 2024

(1) The main aim of this study was to analyze the relationship Mediterranean diet (MD) with vascular function in participants and without increased insulin resistance (IR) Spanish population. A secondary differences by gender. (2) Methods: Data were analyzed from 3401 subjects EVA, MARK, EVIDENT studies (mean age = 60 years 57% men). IR evaluated triglyceride glucose index (TyG index). TyG Ln [(fasting mg/dL × fasting mg/dL)/2]. MD measured against MEDAS questionnaire, 14 items used PREDIMED study. Vascular stiffness estimated brachial–ankle pulse wave velocity (baPWV) cardio ankle (CAVI) using Vasera VS-1500®. (3) Results: mean value 5.82 ± 2.03; (men: 5.66 2.06; women: 6.04 1.99; p < 0.001). adherence 36.8% 34.2%; 40.3%; baPWV 14.39 2.78; 14.50 2.65; 14.25 2.93; 0.005). ≥ 14.5 m/s found 43.4% 43.6%; 40.0%; 0.727). CAVI 8.59 1.28; 8.75 8.37 1.26; values 9 present 39.0% 44.4%; 31.7%; TGC/G 10.93 1.39; 11.08 1.33; 10.73 1.43; 49.9%. average score negatively associated all groups (<0.05), except group women resistance. (4) Conclusions: results suggest that is parameters studied

Language: Английский

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Correlation between METS-IR index and obstructive sleep apnea in non- diabetic adults: evidence from NHANES 2001–2018

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Background: Insulin resistance (IR) is strongly associated with obstructive sleep apnea (OSA). Whereas, few studies have focused on the potential correlation between Metabolic Score for Resistance (METS-IR), a novel non-insulin-dependent IR index, and OSA. Methods: Subjects from National Health Nutrition Examination Survey (NHANES) spanning 2005-2008 2015-2018 were recruited. The relationship METS-IR other indices OSA was explored through three logistic regression analysis models restricted cubic spline (RCS) curves. Receiver operating characteristic (ROC) curves used to assess diagnostic value of these indicators On basis age, sex, race, body mass index (BMI), hypertension, cardiovascular disease (CVD), subgroup analyses conducted test robustness relationship. Results: In all 6,633 non-diabetic participants enrolled, an prevalence 28.40%. After adjusting confounders, METS-IR, triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio, glucose Index (TyG), homeostatic model assessment insulin (HOMA-IR) showed positive associations prevalence. highest tertile TG/HDL-C, TyG HOMA-IR indices, 3.22-fold, 1.42-fold, 1.45-fold, 1.51-fold higher, respectively, compared lowest (METS-IR: OR = 3.22, 95% CI: 2.67, 3.89, P < 0.0001; TG/HDL-C: 1.42, 1.15, 1.76, =0.002; index: 1.45, 1.18, 1.78, P<0.001; HOMA-IR: 1.51, 1.24, 1.85, <0.001). ROC revealed that had accuracy (AUC 0.65). did not show significant interaction across subgroups (P > 0.05). Conclusion: Compared HOMA-IR, TG/HDL-C TyG, positively correlated superior accuracy.

Language: Английский

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