New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 766 - 766

Published: April 28, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to joint damage and even permanent disability, seriously affecting patients’ quality of life. At present, the complete cure for RA not achievable, only relieve symptoms reduce pain patients. Factors such as environment, genes, sex induce RA. Presently, non-steroidal anti-inflammatory drugs, DRMADs, glucocorticoids are commonly used in treating In recent years, some biological agents have also been applied clinical practice, but most side effects. Therefore, finding new mechanisms targets necessary. This review summarizes potential discovered from perspective epigenetics mechanisms.

Language: Английский

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Genetics, epigenetics and autoimmunity constitute a Bermuda triangle for the pathogenesis of rheumatoid arthritis

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123075 - 123075

Published: Sept. 26, 2024

Language: Английский

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Cell-Free DNA in Rheumatoid Arthritis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 8941 - 8941

Published: Aug. 19, 2021

Endogenous DNA derived from the nuclei or mitochondria is released into bloodstream following cell damage death. Extracellular DNA, called cell-free (cfDNA), associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including levels, integrity, methylation, and mutations. Rheumatoid arthritis (RA) most common form autoimmune arthritis, treatment RA has highly varied outcomes. in patients elevated peripheral blood synovial fluid disease activity. Profiling may then be utilized clinical practice, such as prediction prognosis responses; monitoring state; a diagnostic marker. In this review, we discuss RA, particularly sources correlation pathogenesis. We also highlight potential analyzing profiles to guide individualized approaches for RA.

Language: Английский

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Fibroblast pathology in inflammatory joint disease

Immunological Reviews, Journal Year: 2021, Volume and Issue: 302(1), P. 163 - 183

Published: June 6, 2021

Abstract Rheumatoid arthritis is an immune‐mediated inflammatory disease in which fibroblasts contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of the lining cavity called synovial membrane. Under resting conditions, have important role maintaining homeostasis, producing extracellular matrix lubricants. In contrast, during inflammation, pathology by pathogenic levels mediators that drive recruitment retention cells within joint. Recent advances single‐cell profiling techniques transformed our ability examine fibroblast biology, leading identification specific subsets, defining previously underappreciated heterogeneity disease‐associated populations. These studies challenging held dogma homogeneous providing unique insights into their pathology. this review, we discuss recent understanding how contributes rheumatoid arthritis. Finally, address these could lead development novel therapies directly target selective populations future.

Language: Английский

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The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes

Immunologic Research, Journal Year: 2021, Volume and Issue: 69(3), P. 225 - 238

Published: May 13, 2021

Language: Английский

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