Comprehensive analysis of cuproptosis-related lncRNAs model in tumor immune microenvironment and prognostic value of cervical cancer DOI Creative Commons
Qiang Wang, Yue Xu

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 30, 2022

Cervical cancer (CC) is the fourth leading gynecological malignancy in females worldwide. Cuproptosis, a form of cell death induced by copper, elicits novel therapeutic strategy anticancer therapy. Nonetheless, effects cuproptosis-related lncRNAs CC remain unclear. Therefore, we aim to investigate lncRNAs, develop risk model for prognostic prediction, and elucidate immunological profile CC. Transcription profiles clinical follow-up data were retrieved from The Cancer Genome Atlas (TCGA) database. Afterward, was built distinguishing using least absolute shrinkage selection operator (LASSO) Cox regression. correctness validated, nomogram established followed tumor immune microenvironment analysis. Tumor dysfunction exclusion (TIDE) scores used assess immunotherapy response, pharmaceutical half-maximal inhibitory concentration (IC50) prediction performed potential chemotherapy medicines. Finally, through coexpression analysis, 199 collected. A unique generated 6 selected lncRNAs. score reliable independent survival with higher diagnostic effectiveness compared generic characteristics. Immunological infiltration investigation indicated that substantially linked patients’ immunology, low-risk patients had lower TIDE increased checkpoint expression, suggesting stronger response. Besides, high-risk group exhibited distinct sensitivity medications. immune-related progression connected differentially expressed genes (DEGs) between groups. Generally, comprised may help predict overall survival, indicate immunocyte infiltration, identify individualized treatment.

Language: Английский

Cuproptosis: mechanisms and links with cancers DOI Creative Commons
Jiaming Xie, Yannan Yang, Yibo Gao

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 7, 2023

Abstract Cuproptosis was a copper-dependent and unique kind of cell death that separate from existing other forms death. The last decade has witnessed considerable increase in investigations programmed death, whether copper induced an independent form long been argued until mechanism cuproptosis revealed. After that, increasing number researchers attempted to identify the relationship between process cancer. Thus, this review, we systematically detailed systemic cellular metabolic processes copper-related tumor signaling pathways. Moreover, not only focus on discovery its mechanism, but also outline association cancers. Finally, further highlight possible therapeutic direction employing ion ionophores with cuproptosis-inducing functions combination small molecule drugs for targeted therapy treat specific

Language: Английский

Citations

398
Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma DOI Creative Commons
Liping Wang, Dujuan Wang,

Liu Yang

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 23, 2022

Nasopharyngeal carcinoma (NPC) is the most common subcategory of head and neck squamous cell (HNSCC). This study focused on roles cuproptosis related genes Jab1 in tumor microenvironment NPC HNSCC.Differential expression analysis enriched region (PanCK-expressing) immune (CD45-expressing) were performed by packages R software. Survival was using survival survminer packages. Corrplot package used for correlation analysis. ConsensusClusterPlus cluster clustering among different regions NPC, functional enrichment GSVA, GSEABase, clusterProfiler, org.Hs.eg.db enrichplot The pRRophetic to predict drug sensitivity HNSCC.Relationships exist between microenvironment. differed region. AKT inhibitor VIII, Doxorubicin, Bleomycin Etoposide showed higher than cell. In high group, ATP7A, DBT, DLD LIAS associated with better prognosis HNSCC patients. contrast, low these worse patients.Prognostic provided a basis targeted therapy development.

Language: Английский

Citations

55
The expression of cuproptosis-related genes in hepatocellular carcinoma and their relationships with prognosis DOI Creative Commons
Xueying Zhao, Jin Chen,

Shangqi Yin

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Oct. 14, 2022

The mechanism of cuproptosis has recently been reported in lipoylated proteins the tricarboxylic acid (TCA) cycle. Besides, role copper was previously recognized cancer progression. We evaluated prognostic value cuproptosis-related gene expression hepatocellular carcinoma (HCC). Remarkable genes were selected both differential analysis and Kaplan-Meier survival from ninety-six using Cancer Genome Atlas (TCGA) database. relationships between clinical characteristics performed with Wilcoxon signed-rank test, Kruskal-Wallis logistic regression. Clinicopathologic factors correlated overall HCCs conducting univariate multivariate Cox regression analysis. Gene Expression Profiling Interactive Analysis 2 (GEPIA2) Human Protein (HPA) databases utilized to verify results. Furthermore, Set Enrichment (GSEA) identified potential key pathways that dominate HCC. Elevated ATP7A, SLC25A3, SCO2, COA6, TMEM199, ATP6AP1, LIPT1, DLAT, PDHA1, MTF1, ACP1, FDX2, NUBP2, CIAPIN1, ISCA2 NDOR1 expression, as well declined AOC1, FDX1, MT-CO1, ACO1 significantly emerged HCC tumor tissues associated poor survival. expressions screened prominently related features. GSEA many signaling (such natural killer cell mediated cytotoxicity, TCA cycle, glutathione metabolism, ATP-binding cassette (ABC) transporters, Notch pathway, ErbB metabolism xenobiotics by cytochrome p450) differentially enriched varying degrees expression. twenty might be new candidate biomarkers for

Language: Английский

Citations

38
Construction and validation of a cuproptosis-related prognostic model for glioblastoma DOI Creative Commons
Bohong Zhang, Lin Xie, Jiahao Liu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Cuproptosis, a newly reported type of programmed cell death, takes part in the regulation tumor progression, treatment response, and prognosis. But specific effect cuproptosis-related genes (CRGs) on glioblastoma (GBM) is still unclear.The transcriptome data corresponding clinical GBM samples were downloaded from TCGA GEO databases. R software packages used to perform statistical analysis, consensus cluster survival Cox regression Lasso microenvironment analysis. The mRNA protein expression levels model-related detected by RT-qPCR Western blot assays, respectively.The profile CRGs 209 two separate datasets was obtained. Two cuproptosis subtypes, CRGcluster A B, identified There apparent differences prognosis, microenvironment, immune checkpoint between there 79 prognostic differentially expressed (DEGs). According DEGs, gene geneCluster identified, risk score model constructed validated. This consists five including PDIA4, DUSP6, PTPRN, PILRB, CBLN1. Ultimately, improve applicability model, nomogram established. Patients with low-risk have higher mutation burden predict longer OS than high-risk group. Moreover, related drug sensitivity negatively correlated CSC index.We successfully which can independently prognosis patients. These results further complement understanding provide new theoretical support for developing more effective strategy.

Language: Английский

Citations

27
lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ehssan Moglad

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

Citations

9
Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets DOI

Shen’er Qian,

Guolin Tan, Guang Lei

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(1), P. 189265 - 189265

Published: Jan. 13, 2025

Language: Английский

Citations

1
A novel cuproptosis-related lncRNA signature predicts the prognosis and immune landscape in bladder cancer DOI Creative Commons
Yuchen Bai, Qi Zhang, Feng Liu

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 14, 2022

Bladder cancer (BLCA) is one of the deadliest diseases, with over 550,000 new cases and 170,000 deaths globally every year. Cuproptosis a copper-triggered programmed cell death associated prognosis immune response various cancers. Long non-coding RNA (lncRNA) could serve as prognostic biomarker involved in progression BLCA.The gene expression profile cuproptosis-related lncRNAs was analyzed by using data from The Cancer Genome Atlas. Cox regression analysis least absolute shrinkage selection operator were performed to construct lncRNA signature. predictive performance this signature verified ROC curves nomogram. We also explored difference immune-related activity, tumor mutation burden (TMB), dysfunction exclusion (TIDE), drug sensitivity between high- low-risk groups.We successfully constructed for BLCA including eight (RNF139-AS1, LINC00996, NR2F2-AS1, AL590428.1, SEC24B-AS1, AC006566.1, UBE2Q1-AS1, AL021978.1). Multivariate suggested that age, clinical stage, risk score independent factors predicting BLCA. Further revealed not only had higher diagnostic efficiency compared other features but good 1-year, 3-year, 5-year overall survival rate Notably, patients low seemed be an inflamed microenvironment TMB level than those high score. In addition, TIDE half maximal inhibitory concentration value many therapeutic drugs score.We identified novel predict landscape

Language: Английский

Citations

37
A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022 DOI Creative Commons
Yandong Miao, Wuxia Quan, Xin Dong

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: April 15, 2023

This study aims to visualize research hotspots and trends of "ferroptosis in cancer", "necroptosis "pyroptosis "cuproptosis cancer" through a bibliometric analysis facilitate understanding future developments basic clinical provide new perspective on cancer treatment. From January 1, 2012 October 31, 2022, the field total 2467 organizations from 79 different countries published 3302 articles. 2274 72 2233 articles " necroptosis cancer". 1366 institutions 58 contributed 1445 publications In cuproptosis number last 10 years is relatively low, with 109 by 116 four countries. Tang Daolin had 66 documents, ranked first, while Dixon SJ most cited author, 3148 times; fields Vandenabeele peter 35 papers Degterev been 995 times, respectively; Kanneganti thirumala-devi 24 papers, highest Shi JJ was author being 508 times. Both Huang Yan Wang Tao three tied for first place Tsvetkov p ranks 107 times "Cell", "Nature", "Science" frequently co-cited journal respectively. Further exploration inhibitors Programmed cell death (PCD) their targeted therapies are potential treatment options cancer, but more direct evidence as well higher level trials remain be explored. clarification mechanisms crosstalk between these PCDs may effective treatments. And role types PCDs, especially novel ones discovered, can expected hot topic quite some time come.

Language: Английский

Citations

19
Identification of cuproptosis-related lncRNAs with the significance in prognosis and immunotherapy of oral squamous cell carcinoma DOI
Han Gong, Zhaolong Liu,

Chunhui Yuan

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 171, P. 108198 - 108198

Published: Feb. 21, 2024

Language: Английский

Citations

6
Cuproptosis-related lncRNA signature for prognostic prediction in patients with acute myeloid leukemia DOI Creative Commons
Yidong Zhu,

Jun He,

Zihua Li

et al.

BMC Bioinformatics, Journal Year: 2023, Volume and Issue: 24(1)

Published: Feb. 3, 2023

Long non-coding RNAs (lncRNAs) have been reported to a crucial impact on the pathogenesis of acute myeloid leukemia (AML). Cuproptosis, copper-triggered modality mitochondrial cell death, might serve as promising therapeutic target for cancer treatment and clinical outcome prediction. Nevertheless, role cuproptosis-related lncRNAs in AML is not fully understood.The RNA sequencing data demographic characteristics patients were downloaded from The Cancer Genome Atlas database. Pearson correlation analysis, least absolute shrinkage selection operator algorithm, univariable multivariable Cox regression analyses applied identify lncRNA signature determine its feasibility prognosis performance proposed was evaluated via Kaplan-Meier survival receiver operating characteristic curves, principal component analysis. Functional analysis implemented uncover potential prognostic mechanisms. Additionally, quantitative real-time PCR (qRT-PCR) employed validate expression samples.A consisting seven (namely NFE4, LINC00989, LINC02062, AC006460.2, AL353796.1, PSMB8-AS1, AC000120.1) proposed. Multivariable cox revealed that an independent factor AML. Notably, nomogram based this showed excellent accuracy predicting 1-, 3-, 5-year (area under curve = 0.846, 0.801, 0.895, respectively). results suggested existence significant association between immune-related pathways. pattern validated samples.Collectively, we constructed prediction model prognosis. obtained risk score may reveal immunotherapy response with disease.

Language: Английский

Citations

16