Lack of effects on female fertility and prenatal and postnatal offspring development in rats with BNT162b2, a mRNA-based COVID-19 vaccine

Reproductive Toxicology, Journal Year: 2021, Volume and Issue: 103, P. 28 - 35

Published: May 28, 2021

BNT162b2 is a vaccine developed to prevent coronavirus disease 2019 (COVID-19). lipid nanoparticle formulated nucleoside-modified messenger RNA (mRNA) encoding the severe acute respiratory syndrome 2 (SARS-CoV-2) spike protein locked in its prefusion conformation. A developmental and reproductive toxicity study was conducted rats according international regulatory guidelines. The full human dose of 30 μg mRNA/dose (>300 times on mg/kg basis) administered intramuscularly 44 female 21 14 days prior mating gestation 9 20. Half were subject cesarean section fetal examination at end gestation, other half allowed deliver monitored lactation. robust neutralizing antibody response confirmed presence antibodies also fetuses offspring. Nonadverse effects, related local injection site reaction, noted dams as expected from animal studies consistent with observations humans. There no effects performance, fertility, or any ovarian uterine parameters nor embryo-fetal postnatal survival, growth, physical development neurofunctional offspring through Together safety profile nonpregnant people, this ICH-compliant nonclinical data supports women childbearing potential pregnant lactating women.

Language: Английский

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Sex differences in frailty among older adults

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 184, P. 112333 - 112333

Published: Dec. 1, 2023

By definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects increase in vulnerability to stressors shortens time without disease (health span) while longevity refers length of life (lifespan). The average expectancy has significantly increased during last few decades. A longer lifespan been accompanied by an decreased independence older adults, with major differences existing between men women. For example, women tend live than but also experience higher rates disability. Sex prevent optimization lifestyle interventions therapies effectively frailty. are rooted complex interplay uncontrollable (genetic, epigenetic, physiological), controllable factors (psychosocial factors). Thus, understanding underlying causes sex essential for developing personalized promote healthy improve quality In this review, we have discussed key contributors knowledge gaps related

Language: Английский

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Effect of COVID-19 on antenatal care: experiences of medical professionals in the Netherlands

Reproductive Health, Journal Year: 2023, Volume and Issue: 20(1)

Published: March 8, 2023

COVID-19 has greatly affected the delivery of all health care services globally. Antenatal is one area that been impacted, despite fact attending antenatal check-ups essential for pregnant women and cannot be postponed. Little known about how exactly ANC provision changed in Netherlands, or changes have impacted midwives gynaecologists providing those services.This study used a qualitative research design to investigate individual national practice following onset pandemic. The involved document analysis protocols guidelines evaluate pandemic semi-structured interviews with providers (i.e., midwives).Guidance was issued by multiple organizations, during pandemic, on approach risk infection women, recommending several protect both providers. Both reported their practice. With less face-to-face consultations happening, digital technologies became critical women. Shorter fewer visits were reported, midwifery practices adjusting further than hospitals. Challenges, high workloads lack personal protective equipment discussed.The had an immense impact system. This negative positive effects Netherlands. It important learn from current adapt ANC, as well systems whole, better prepared future crises ensure continuous good quality care.COVID-19 healthcare global scale. Netherlands period. Our project focuses examining existing protocols, impacts providers, such gynaecologists. knowledge can beneficial adapting times emergencies, more resilient. uses involves 20 working which took part interviews, 9 analysed. indicates at different levels Many show service, should not cut back, but it implemented, emergency.

Language: Английский

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The New Status of Parasitic Diseases in the COVID-19 Pandemic—Risk Factors or Protective Agents?

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(11), P. 2533 - 2533

Published: June 7, 2021

It is possible that parasites may influence the course of COVID-19 infection, as either risk factors or protective agents; such, current coronavirus pandemic affect diagnosis and prevention parasitic disease, its elimination programs. The present review highlights similarity between symptoms human parasitoses those discuss their mutual influence. study evaluated selected with similar to examined potential on SARS-CoV-2 virus invasion. available data suggest at least several could result in misdiagnosis COVID-19. Some disorders, such malaria, schistosomiasis soil-transmitted helminths, can increase severe infection also suggested recovery from disease enhance immune system protect infection. In addition, has affected programs endemic regions influenced number diagnoses parasitoses.

Language: Английский

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Genetic and infectious determinants of puerperal fever: a study of viral and bacterial coinfections in postpartum women

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 3, 2025

Abstract Background Puerperal fever is a major cause of maternal morbidity, traditionally associated with bacterial infections. However, the role viral pathogens and genetic factors remains inadequately studied, particularly in low- middle-income countries (LMICs). Objective This study aimed to investigate prevalence infections, pathogens, variants postpartum women diagnosed puerperal at Edo State University Teaching Hospital, Auchi, Nigeria. Methods A cross-sectional involving 300 (200 100 controls) was conducted from April 2021 May 2022. Blood samples were analyzed for antibodies DNA/RNA using Bio-Rad ELISA kits polymerase chain reaction (PCR). PCR–RFLP real-time PCR TaqMan probes used genotyping. Bacterial identified through culture techniques. Genetic polymorphisms immune-regulatory genes (IL-6, TNF-α, TLR4, HLA Class I II) PCR-based methods. Statistical analysis employed SPSS version 25, Chi-square tests, multivariate logistic regression, corrections multiple comparisons. Results The group showed significantly higher rates Cytomegalovirus (CMV) (40% vs. 10%, p < 0.001), Herpes Simplex Virus (HSV-1: 35% 15%, = 0.002; HSV-2: 28% 14%, 0.01), Epstein-Barr (EBV) (30% 12%, 0.005). confirmed presence group: CMV (30%), HSV-1 (25%), HSV-2 (20%), EBV (22%), compared controls (5%, 8%, 6%, 4%, respectively). infections more prevalent group, Streptococcus pyogenes (32% 0.001) Escherichia coli (25% 0.002) being notable contributors. Additionally, IL-6 (rs1800795) TNF-α (rs1800629) an increased risk ( 0.05). controlled confounding variables such as socioeconomic health status. Conclusion highlights dual well factors, fever. findings underscore need integrated diagnostic approaches, including screening testing, enhance outcomes LMICs.

Language: Английский

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Assessing SARS-CoV-2 Vertical Transmission and Neonatal Complications

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(22), P. 5253 - 5253

Published: Nov. 11, 2021

We designed and implemented a prospective study to analyze the maternal neonatal outcomes associated with COVID-19 determine likelihood of viral transmission fetus newborn by collecting samples from amniotic fluid, placenta, umbilical cord blood, breast milk. The followed observational design, starting in July 2020 lasting for one year. A total 889 pregnant women were routinely tested SARS-CoV-2 infection an outpatient setting at our clinic, using nasal swabs PCR testing. 76 diagnosed COVID-19. positive patients who accepted enrollment systematically analyzed weekly nasal, urine, fecal, serum samples, including cord, milk hospital admission postpartum. Mothers significantly higher risk developing gestational hypertension giving birth prematurely c-section than general population. Moreover, their mortality rates substantially higher. Their newborns did not have negative outcomes, except prematurity, insignificant number infected (5.4%). No fluid SARS-CoV-2, only 1.01% tests confirmed positive. Based on these results, we support idea that do expose infants additional via breastfeeding, close contact, or in-utero. Consequently, maternal-newborn separation delivery since they seem be increased infection.

Language: Английский

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Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases

Biomolecules and Biomedicine, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 20, 2023

Vaccination is significant to control, mitigate, and recover from the destructive effects of coronavirus disease 2019 (COVID-19). The incidence myocarditis following COVID-19 vaccination has been increasing growing public concern; however, little known about it. This study aimed systematically review vaccination. We included studies containing individual patient data published between January 1, 2020 September 7, 2022 excluded articles. Joanna Briggs Institute critical appraisals were used for risk bias assessment. Descriptive analytic statistics performed. A total 121 reports 43 case series five databases included. identified 396 cases observed that majority was male patients, happened second dose mRNA vaccine administration, experienced chest pain as a symptom. Previous infection significantly associated (p < 0.01; OR, 5.74; 95% CI, 2.42-13.64) with administration first dose, indicating its primary mechanism immune-mediated. Moreover, 63 histopathology examinations dominated by non-infective subtypes. Electrocardiography cardiac marker combination sensitive screening modality. However, magnetic resonance noninvasive examination confirm myocarditis. Endomyocardial biopsy may be considered in confusing severe cases. Myocarditis relatively benign, median length hospitalization 5 days, intensive care unit admission <12%, mortality <2%. treated nonsteroidal anti-inflammatory drugs, colchicine, steroids. Surprisingly, deceased had characteristics being female, older age, non-chest symptoms, first-dose vaccination, left ventricular ejection fraction <30%, fulminant myocarditis, eosinophil infiltrate histopathology.

Language: Английский

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COVID-19 in pregnant women

Saudi Medical Journal, Journal Year: 2022, Volume and Issue: 43(4), P. 378 - 385

Published: April 1, 2022

To investigate the association between hospitalization rates, symptoms, and laboratory parameters of pregnant women diagnosed with coronavirus disease 2019 (COVID-19) gestational week, determine their symptoms or predictive need for possible admission in intensive care unit (ICU).We retrospectively analyzed parameters, treatment modalities 175 COVID-19 who were admitted to a tertiary referral hospital March 2020 2021 investigated pregnancy trimesters.The COVID-19-related rates first trimester was 24.1%, second trimesters 36%, third 57.3%. Cough shortness breath significantly higher than those 2 (p=0.042 p=0.026, respectively). No significant relationship found ICU admission. Shortness at increased by 6.95 times, 1 increase C-reactive protein (CRP) level risk 1.003 times.The presence respiratory later COVID-19. The high CRP time could predict

Language: Английский

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Respiratory perspective of COVID-19 in pregnancy

The Journal of Infection in Developing Countries, Journal Year: 2023, Volume and Issue: 17(01), P. 23 - 36

Published: Jan. 31, 2023

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), was declared a global pandemic in March 2020 World Health Organization (WHO). By February 2022, had infected more than 500 million people globally. COVID-19 frequently manifests as pneumonia and mortality is mainly distress (ARDS). Previous studies have reported that pregnant women are at higher risk of SARS-CoV-2 infection complications can happen due to alterations immune response, physiology, hypercoagulable state, placental pathology. Clinicians face challenge selecting proper treatment for patients with different physiological characteristics compared non-pregnant population. Furthermore, drug safety both patient fetus should also be considered. Efforts prevent COVID-19, including prioritizing vaccination women, essential break chain transmission This review aims summarize current literature regarding effect its clinical manifestations, treatment, complications, prevention.

Language: Английский

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COVID-19 and pregnancy: a comprehensive study of comorbidities and outcomes

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 13, 2024

This study aimed to investigate the impact of pregnancy and pre-existing comorbidities on COVID-19 infections associated complications hospitalisation mortality in women reproductive age (WRA). The also compared risk severe between pregnant (PW) non-pregnant (NPW) with without comorbidities. Special focus was placed some understudied immunosuppression, chronic renal disease obstructive pulmonary (COPD). utilized anonymized patient-related information for a population 7,342,869 WRA from Mexican Ministry Health data repository COVID-19. Descriptive variables were characterized using frequencies, percentages, means, standard deviations. Adjusted odds ratios (aORs) used assess associations factors outcomes mortality. covered entire pandemic period January 30, 2020, May 5, 2023. findings revealed that PW not more likely get than NPW. require hospital admission, intubation treatments, ICU admission NPW immunosuppression had an increased ratio (aOR) getting (PW: aOR = 1.0396; NPW: 0.8373). higher (all-cause death: 1.7084; COVID-19-associated 1.4079) hospitalisation: 4.1328; 3.0451) immunosuppression. Renal identified as concerning condition risks mortality/hospitalizations all-cause both much either COVID-19-associated-hospitalisations (NPW: 8.639; PW: 1.7603) or hospitalisations 8.8594; 1.786) disease. provides valuable insights into WRA. underscore importance considering demographic management highlights need further research understand unique impacts different comorbidities, particularly disease,

Language: Английский

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