Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Blood, Journal Year: 2020, Volume and Issue: 136(10), P. 1169 - 1179

Published: June 29, 2020

Language: Английский

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Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Science, Journal Year: 2018, Volume and Issue: 361(6409)

Published: Sept. 28, 2018

Waking up in a trap Cancer patients who have undergone successful treatment can experience relapse of their disease years or even decades later. This is because cancer cells that disseminated beyond the primary tumor site enter state dormancy, where they remain viable but not proliferating. Eventually, by mechanisms are poorly understood, these clinically undetectable “wake up” and form actively growing metastases. Studying mouse models, Albrengues et al. found sustained lung inflammation accompanying formation neutrophil extracellular traps (NETs) could convert dormant to aggressive metastases (see Perspective Aguirre-Ghiso). Awakening was associated with NET-mediated remodeling matrix be prevented an antibody against remodeled version protein called laminin-111. Science , this issue p. eaao4227 ; see also 1314

Language: Английский

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Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility

Frontiers in Bioengineering and Biotechnology, Journal Year: 2018, Volume and Issue: 6

Published: July 16, 2018

Hemocompatibility of blood-contacting biomaterials is one the most important criteria for their successful in vivo applicability. Thus, extensive vitro analyses according to ISO 10993-4 are required prior clinical applications. In this review, we summarize essential aspects regarding evaluation hemocompatibility and determining blood compatibility. Static, agitated, or shear flow models used perform studies. Before after incubation test material with fresh human blood, hemolysis, cell counts, activation platelets, leukocytes, coagulation complement system analyzed. Furthermore, surface evaluated concerning attachment cells, adsorption proteins, generation thrombus fibrin networks.

Language: Английский

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DAMPs and NETs in Sepsis

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Oct. 30, 2019

Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. Much has been focused on host pathogens mediated through the interaction of pathogen-associated molecular patterns (PAMPs) and pattern recognition receptors (PRRs). PRRs are also activated nuclear, mitochondrial, cytosolic proteins, known as damage-associated (DAMPs) that released from cells during sepsis. Some well described members DAMP family extracellular cold-inducible RNA-binding protein (eCIRP), high mobility group box 1 (HMGB1), histones, adenosine triphosphate (ATP). DAMPs cell inflammasome activation or passively following death. Similarly, neutrophil traps (NETs) neutrophils inflammation. NETs webs DNA decorated with myeloperoxidase, elastase. Although contribute pathogen clearance, excessive NET formation promotes inflammation tissue damage in Here, we review their crosstalk sepsis respect sources, activation, release, function. A clear understating DAMPs, crucial for understanding pathophysiology development novel therapeutics.

Language: Английский

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Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

Cancer Cell, Journal Year: 2021, Volume and Issue: 39(3), P. 423 - 437.e7

Published: Jan. 15, 2021

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic colonization lungs. Here, we show that tumor-secreted protease cathepsin C (CTSC) promotes breast-to-lung by regulating recruitment neutrophils and formation neutrophil extracellular traps (NETs). CTSC enzymatically activates membrane-bound proteinase 3 (PR3) to facilitate interleukin-1β (IL-1β) processing nuclear factor κB activation, thus upregulating IL-6 CCL3 for recruitment. In addition, CTSC-PR3-IL-1β axis induces reactive oxygen species production NETs, which degrade thrombospondin-1 support growth cancer expression secretion are associated with NET lung human tumors. Importantly, targeting compound AZD7986 effectively suppresses a mouse model. Overall, our findings reveal mechanism how regulate niches CTSC-targeting approaches treatment.

Language: Английский

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A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

Clinical Reviews in Allergy & Immunology, Journal Year: 2020, Volume and Issue: 61(2), P. 194 - 211

Published: Aug. 1, 2020

Language: Английский

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Cellular Mechanisms of NETosis

Annual Review of Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 36(1), P. 191 - 218

Published: July 14, 2020

Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their role by phagocytosing pathogens, secreting granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process NETosis. NETs weblike DNA structures decorated with histones antimicrobial proteins released activated neutrophils. Initially described as a means for neutrophils neutralize NET release also occurs in sterile inflammation, promotes thrombosis, can mediate tissue damage. To effectively manipulate this double-edged sword fight particular disease, researchers must work toward understanding mechanisms driving Such would allow generation new drugs promote prevent NETosis needed. While knowledge regarding (patho)physiological roles is accumulating, little known about cellular biophysical bases process. In review, we describe discuss our current molecular, cellular, mediating well open questions field.

Language: Английский

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The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: May 28, 2020

Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and transferred into between cells, serum, bile cerebrospinal fluid, via variety of receptors. has important immunological properties, both antibacterial antiviral. In particular, there evidence that it can bind to at least some the receptors used by coronaviruses thereby block their entry. may consequently be preventive therapeutic value during present COVID-19 pandemic.

Language: Английский

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Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

Journal of Hepatology, Journal Year: 2022, Volume and Issue: 77(4), P. 1136 - 1160

Published: June 22, 2022

Language: Английский

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Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease

Archives of Biochemistry and Biophysics, Journal Year: 2018, Volume and Issue: 645, P. 61 - 71

Published: March 18, 2018

Language: Английский

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